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المؤلفون: Geoffrey I, Shapiro, Patricia, LoRusso, Daniel C, Cho, Luna, Musib, Yibing, Yan, Matthew, Wongchenko, Ilsung, Chang, Premal, Patel, Iris T, Chan, Sandra, Sanabria-Bohorquez, Raymond D, Meng, Johanna C, Bendell
المصدر: Investigational new drugs. 39(1)
مصطلحات موضوعية: Aged, 80 and over, Male, Dose-Response Relationship, Drug, Maximum Tolerated Dose, Antineoplastic Agents, Middle Aged, Piperazines, Phosphatidylinositol 3-Kinases, Pyrimidines, Piperidines, Neoplasms, Antineoplastic Combined Chemotherapy Protocols, Azetidines, Humans, Female, Mitogen-Activated Protein Kinases, Aged
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=pmid________::df5501d3fe3994980603d698e0f98cefTest
https://pubmed.ncbi.nlm.nih.gov/32737717Test -
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المؤلفون: Lee S. Rosen, Angela Shen, Amy Weise, Jonathan W. Goldman, A. Dimitrios Colevas, Alex A. Adjei, Salim Yazji, Hsin Ju Hsieh, Iris T. Chan, Patricia LoRusso, Branimir I. Sikic, Wen Wee Ma, Stuart Johnston
المصدر: Investigational new drugs, vol 34, iss 5
مصطلحات موضوعية: Male, 0301 basic medicine, MAP Kinase Kinase 2, MAP Kinase Kinase 1, Pharmacology, Gastroenterology, chemistry.chemical_compound, 0302 clinical medicine, Piperidines, Neoplasms, Cobimetinib, 80 and over, Pharmacology (medical), Melanoma, ras, Cancer, Aged, 80 and over, MEK inhibitor, Pharmacology and Pharmaceutical Sciences, Middle Aged, Rash, Treatment Outcome, Oncology, 6.1 Pharmaceuticals, 030220 oncology & carcinogenesis, Vomiting, Female, medicine.symptom, Proto-Oncogene Proteins B-raf, Adult, medicine.medical_specialty, Maximum Tolerated Dose, Class I Phosphatidylinositol 3-Kinases, Nausea, Clinical Trials and Supportive Activities, Antineoplastic Agents, Article, BRAF, Proto-Oncogene Proteins p21(ras), Vaccine Related, 03 medical and health sciences, Phase I, Pharmacokinetics, Clinical Research, Internal medicine, medicine, Humans, Oncology & Carcinogenesis, Adverse effect, Protein Kinase Inhibitors, Aged, business.industry, Evaluation of treatments and therapeutic interventions, Genes, ras, 030104 developmental biology, Genes, chemistry, Pharmacodynamics, Mutation, Azetidines, business
وصف الملف: application/pdf
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::361923aa9fba431e1a3e3e602c6cb5c0Test
https://doi.org/10.1007/s10637-016-0374-3Test -
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المؤلفون: D. Gary Gilliland, Timothy J. Ley, Ifor R. Williams, Jeffery L. Kutok, Michelle M. Le Beau, Koichi Akashi, Sandra A. Moore, Iris T. Chan, Sarah L. Cohen, Hirokazu Shigematsu
المصدر: Blood. 108:1708-1715
مصطلحات موضوعية: Acute promyelocytic leukemia, Myeloid, Oncogene Proteins, Fusion, Immunology, Retinoic acid, Mice, Transgenic, Biology, medicine.disease_cause, Biochemistry, Mice, chemistry.chemical_compound, Leukemia, Promyelocytic, Acute, Bone Marrow, medicine, Animals, Humans, Arsenic trioxide, neoplasms, Neoplasia, Cell Biology, Hematology, Flow Cytometry, medicine.disease, Survival Analysis, Leukemia, Genes, ras, medicine.anatomical_structure, Liver, Ras Signaling Pathway, chemistry, Karyotyping, Cancer research, Bone marrow, Carcinogenesis, Spleen
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ee8c6b8d2ba28655600e9b27f603381Test
https://doi.org/10.1182/blood-2006-04-015040Test -
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المؤلفون: Iris T. Chan, Jeffery L. Kutok, Leisa Johnson, Sarah L. Cohen, Lauren Kelly, Tyler Jacks, Hirokazu Shigematsu, Ifor R. Williams, D. Gary Gilliland, David A. Tuveson, Koichi Akashi
المصدر: Journal of Clinical Investigation. 113:528-538
مصطلحات موضوعية: Adenoma, Myeloid, Bone Marrow Cells, Mice, Inbred Strains, Mice, Transgenic, Biology, Gene dosage, Article, Mice, Myeloproliferative Disorders, Neoplasms, medicine, Animals, Humans, Promoter Regions, Genetic, Alleles, Cells, Cultured, Bone Marrow Transplantation, Regulation of gene expression, Papilloma, Myeloid leukemia, General Medicine, Hematopoietic Stem Cells, medicine.disease, Gene Expression Regulation, Neoplastic, Leukemia, Myeloid, Acute, Haematopoiesis, Leukemia, Genes, ras, Phenotype, medicine.anatomical_structure, Cancer research, Bone marrow
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4207259d0f9b09a013350cbf4906bbc9Test
https://doi.org/10.1172/jci20476Test -
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المؤلفون: D. Gary Gilliland, Iris T. Chan
المصدر: Principles of Molecular Medicine ISBN: 9781588292025
مصطلحات موضوعية: Acute promyelocytic leukemia, business.industry, Hematopoietic stem cell, Disease, medicine.disease, Core binding factor, Leukemia, medicine.anatomical_structure, hemic and lymphatic diseases, Cancer research, Medicine, Hematopoietic progenitor cells, Allele, business, Acute myeloid leukemias, neoplasms
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::22182dd3f062f95ffdad872a12b42e15Test
https://doi.org/10.1007/978-1-59259-963-9_79Test