Pro- and anti-tumorigenic functions of the senescence-associated secretory phenotype
| العنوان: | Pro- and anti-tumorigenic functions of the senescence-associated secretory phenotype |
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| المؤلفون: | Gregory David, Lena Lau |
| المصدر: | Expert Opin Ther Targets |
| بيانات النشر: | Informa UK Limited, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | 0301 basic medicine, Senescence, Carcinogenesis, Clinical Biochemistry, Cellular senescence, Inflammation, Biology, medicine.disease_cause, Article, 03 medical and health sciences, 0302 clinical medicine, Neoplasms, Drug Discovery, medicine, Animals, Humans, Secretion, Precision Medicine, Cellular Senescence, Pharmacology, Senescence-Associated Secretory Phenotype, fungi, Cell cycle, Phenotype, Cell biology, 030104 developmental biology, 030220 oncology & carcinogenesis, Molecular Medicine, medicine.symptom |
| الوصف: | INTRODUCTION: Cellular senescence is a stable form of cell-cycle exit. Though they no longer divide, senescent cells remain metabolically active and secrete a plethora of proteins collectively termed the senescence-associated secretory phenotype (SASP). Although senescence-associated cell-cycle exit likely evolved as an anti-tumor mechanism, the SASP contains both anti- and pro-tumorigenic potential. AREAS COVERED: In this review, we briefly discuss the discovery of senescent cells and its relationship to cancer and aging. We also describe the initiation and regulation of the SASP upon senescence stimulus onset. We focus on both the pro- and anti-tumorigenic properties of the SASP. Finally, we speculate on the potential benefits of therapy-induced senescence combined with selective SASP inhibition for the treatment of cancer. EXPERT OPINION: Further identification and characterization of the SASP factors that are pro-tumorigenic and those that are anti-tumorigenic in specific contexts will be crucial in order to develop personalized therapeutics for the successful treatment of cancer. |
| تدمد: | 1744-7631 1472-8222 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d583ae1921a31367b40e8ed8acea51e0Test https://doi.org/10.1080/14728222.2019.1565658Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....d583ae1921a31367b40e8ed8acea51e0 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 17447631 14728222 |
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