التفاصيل البيبلوغرافية
| العنوان: |
Lethal neonatal meningoencephalitis caused by multi-drug resistant, highly virulent Escherichia coli. |
| المؤلفون: |
Iqbal, Junaid1 (AUTHOR), Dufendach, Kevin R.1 (AUTHOR), Wellons, John C.2 (AUTHOR), Kuba, Maria G.3 (AUTHOR), Nickols, Hilary H.3 (AUTHOR), Gómez-Duarte, Oscar G.1 (AUTHOR), Wynn, James L.4 (AUTHOR) james.wynn@peds.ufl.edu |
| المصدر: |
Infectious Diseases. Jun2016, Vol. 48 Issue 6, p461-466. 6p. 1 Illustration. |
| مستخلص: |
Neonatal meningitis is a rare but devastating condition. Multi-drug resistant (MDR) bacteria represent a substantial global health risk. This study reports on an aggressive case of lethal neonatal meningitis due to a MDREscherichia coli(serotype O75:H5:K1). Serotyping, MDR pattern and phylogenetic typing revealed that this strain is an emergent and highly virulent neonatal meningitisE. coliisolate. The isolate was resistant to both ampicillin and gentamicin; antibiotics currently used for empiric neonatal sepsis treatment. The strain was also positive for multiple virulence genes including K1 capsule, fimbrial adhesionfimH, siderophore receptorsiroN,fyuAandiutA, secreted autotransporter toxinsat, membrane associated proteasesompAandompT, type II polysaccharide synthesis genes (kpsMTII) and pathogenicity-associated island (PAI)-associatedmalXgene. The presence of highly-virulent MDR organisms isolated in neonates underscores the need to implement rapid drug resistance diagnostic methods and should prompt consideration of alternate empiric therapy in neonates with Gram negative meningitis. [ABSTRACT FROM PUBLISHER] |
| قاعدة البيانات: |
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