دورية أكاديمية
Ginsenosides in cancer : targeting cell cycle arrest and apoptosis
| العنوان: | Ginsenosides in cancer : targeting cell cycle arrest and apoptosis |
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| المؤلفون: | Shah, Muhammad Ajmal, Abuzar, Syed Muhammad, Ilyas, Kainat, Qadees, Irtaza, Bilal, Momna, Yousaf, Rimsha, Tahir Kassim, Roaa Muhammad, Rasul, Azhar, Saleem, Uzma, Alves, Maria Silvana, Khan, Haroon, Blundell, Renald, Jeandet, Philippe |
| بيانات النشر: | Elsevier Ireland Ltd. |
| سنة النشر: | 2023 |
| المجموعة: | University of Malta: OAR@UM / L-Università ta' Malta |
| مصطلحات موضوعية: | Molecules -- Models -- Data processing, Metabolism -- Disorders, Natural products, Phytochemicals |
| الوصف: | Despite the existence of extensive clinical research and novel therapeutic treatments, cancer remains undefeated and the significant cause of death worldwide. Cancer is a disease in which growth of cells goes out of control, being also able to invade other parts of the body. Cellular division is strictly controlled by multiple checkpoints like G1/S and G2/M which, when dysregulated, lead to uncontrollable cell division. The current remedies which are being utilized to combat cancer are monoclonal antibodies, chemotherapy, cryoablation, and bone marrow transplant etc. and these have also been greatly disheartening because of their serious adverse effects like hypotension, neuropathy, necrosis, leukemia relapse and many more. Bioactive compounds derived from natural products have marked the history of the development of novel drug therapies against cancer among which ginsenosides have no peer as they target several signaling pathways, which when abnormally regulated, lead to cancer. Substantial research has reported that ginsenosides like Rb1, Rb2, Rb3, Rc, Rd, Rg3, Rh2 etc. can prevent and treat cancer by targeting different pathways and molecules by induction of autophagy, neutralizing ROS, induction of cancerous cell death by controlling the p53 pathway, modulation of miRNAs by decreasing Smad2 expression, regulating Bcl-2 expression by normalizing the NF-Kb pathway, inhibition of inflammatory pathways by decreasing the production of cytokines like IL-8, causing cell cycle arrest by restricting cyclin E1 and CDC2, and induction of apoptosis during malignancy by decreasing β-catenin levels etc. In this review, we have analyzed the anti-cancer therapeutic potential of various ginsenoside compounds in order to consider their possible use in new strategies in the fight against cancer. ; peer-reviewed |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 00092797 |
| العلاقة: | Ajmal Shah, M., Abuzar, S. M., Ilyas, K., Qadees, I., Bilal, M., Yousaf, R., Muhammad Tahir Kassim, R., Rasul, A., Saleem, U., Alves, M, S., Khan, H., Blundell, R., & Jeandet, P. (2023). Ginsenosides in cancer : Targeting cell cycle arrest and apoptosis. Chemico-Biological Interactions, 10.1016/j.cbi.2023.110634.; https://www.um.edu.mt/library/oar/handle/123456789/111655Test |
| DOI: | 10.1016/j.cbi.2023.110634 |
| الإتاحة: | https://doi.org/10.1016/j.cbi.2023.110634Test https://www.um.edu.mt/library/oar/handle/123456789/111655Test |
| حقوق: | info:eu-repo/semantics/restrictedAccess ; The copyright of this work belongs to the author(s)/publisher. The rights of this work are as defined by the appropriate Copyright Legislation or as modified by any successive legislation. Users may access this work and can make use of the information contained in accordance with the Copyright Legislation provided that the author must be properly acknowledged. Further distribution or reproduction in any format is prohibited without the prior permission of the copyright holder. |
| رقم الانضمام: | edsbas.B5EF78FD |
| قاعدة البيانات: | BASE |
| تدمد: | 00092797 |
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| DOI: | 10.1016/j.cbi.2023.110634 |