المؤلفون: Veerapandian, Mekala, Ramasundaram, Subramaniyan, Jerome, Peter, Chellasamy, Gayathri, Govindaraju, Saravanan, Yun, Kyusik, Oh, Tae Hwan

المصدر: Journal of Functional Biomaterials; Aug2023, Vol. 14 Issue 7, p426, 22p

مصطلحات موضوعية: NANOSTRUCTURED materials, DRUG delivery systems, BIOMOLECULES, DRUG carriers, PLANT extracts

مستخلص: Nanomaterials (NMs) synthesized from natural sources have been attracting greater attention, due to their intrinsic advantages including biocompatibility, stimuli-responsive property, nontoxicity, cost-effectiveness, and non-immunogenic characteristics in the biological environment. Among various biomedical applications, a breakthrough has been achieved in the development of drug delivery systems (DDS). Biocompatibility is necessary for treating a disease safely without any adverse effects. Some components in DDS respond to the physiological environment, such as pH, temperature, and functional group at the target, which facilitates targeted drug release. NM-based DDS is being applied for treating cancer, arthritis, cardiovascular diseases, and dermal and ophthalmic diseases. Metal nanomaterials and carbon quantum dots are synthesized and stabilized using functional molecules extracted from natural sources. Polymers, mucilage and gums, exosomes, and molecules with biological activities are directly derived from natural sources. In DDS, these functional components have been used as drug carriers, imaging agents, targeting moieties, and super disintegrants. Plant extracts, biowaste, biomass, and microorganisms have been used as the natural source for obtaining these NMs. This review highlights the natural sources, synthesis, and application of metallic materials, polymeric materials, carbon dots, mucilage and gums, and exosomes in DDS. Aside from that, challenges and future perspectives on using natural resources for DDS are also discussed. [ABSTRACT FROM AUTHOR]

: Copyright of Journal of Functional Biomaterials is the property of MDPI and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

المؤلفون: Veerapandian, Murugan¹ (AUTHOR), Yun, Kyusik¹ (AUTHOR) ykyusik@kyungwon.ac.kr

المصدر: Synthesis & Reactivity in Inorganic, Metal-Organic, & Nano-Metal Chemistry. Jan2010, Vol. 40 Issue 1, p56-64. 9p. 3 Diagrams, 5 Graphs.

مصطلحات موضوعية: *SILVER, *GLUCOSAMINE, *HEXOSAMINES, *NANOPARTICLES, *NANOSTRUCTURED materials, *AMINO group

مستخلص: Functionalized nanoparticles are promising candidates for the construction of new nanomaterials. In this paper, glucosamine was covalently functionalized on the surface of silver nanoparticles to fabricate glyconanoparticles. Silver nanoclusters obtained by liquid-solid-solution (LSS) strategy under hydrothermal condition were first functionalized by carboxyl-terminated alkanethiol and the terminal carboxyl group was subsequently bonded with side-chain amino group of glucosamine surface through EDC/NHS coupling reaction. UV-vis spectrometer and EDXA measurements ensure the formation of silver nanoparticles. The surface functionalization of glucosamine on silver nanoparticles was confirmed from the carbonyl group of secondary amide linkage obtained by the conjugation of NHS terminated silver nanoparticles and amino group of glucosamine. This is evinced from the FT-IR characteristic stretching at 1637cm- 1 and 1H-NMR chemical shift from 8.4 to 7.6 ppm, respectively. Morphological images (FE-SEM and AFM) reveal the size and shape of the silver nano-assembly and silver-glucosamine nanoparticles. The fabricated glyconanoparticles with 15 ± 5 nm size can be easily suspended in water, stable over a broader range of pH and would be useful for variety of glyconanotechnology. [ABSTRACT FROM AUTHOR]

المؤلفون: Kim, Byeonghoon, Amin, Rashid, Lee, Junwye, Yun, Kyusik, Park, Sung Ha

المصدر: Chemical Communications; Sep2011, Vol. 47 Issue 39, p11053-11055, 3p

مصطلحات موضوعية: CRYSTAL growth, DNA, NANOSTRUCTURED materials, SOLUTION (Chemistry), MICA, MICROFABRICATION

مستخلص: We designed an artificial one-dimensional DNA nanotrack that contains two T-motifs. It can be fabricated in a free solution and with a mica-assisted growth process. Also, we introduced a dry and wet method for the restoration of DNA nanostructures in order for them to be used in multiple applications. [ABSTRACT FROM AUTHOR]

: Copyright of Chemical Communications is the property of Royal Society of Chemistry and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

المؤلفون: Govindaraju, Saravanan¹, Yun, Kyusik¹ ykyusik@gachon.ac.kr

المصدر: 3 Biotech. 2/5/2018, Vol. 8 Issue 2, p0-0. 1p.

مصطلحات موضوعية: *NANOSTRUCTURED materials, *CARBON nanohorns, *DRUG delivery systems, *NANOMEDICINE, *CANCER treatment

مستخلص: Recently, the advances in the synthesis of new types of nanomaterials have created several opportunities in drug delivery and targeted therapy applications. Among the various nanostructures, gold nanostructures with controllable physical and chemical properties have received attention for various biomedical uses, including sensing of biomolecules, in vitro and in vivo bioimaging (as advanced contrast agents for photothermal and bioimaging techniques), photothermolysis of cancer cells, and targeted drug delivery. The attractive properties of gold nanomaterials, particularly, anti-angiogenic properties, are highly useful in a variety of cancers studies. In addition, they can bind many proteins and drugs and can be actively targeted to cancer cells over-expressing cell surface receptors and they are biocompatible in nature with a high atomic number, which directs to greater absorption of kilovoltage X-rays and provides greater contrast than standard agents. In this review, we have summarized the synthesis, structure and functionalization of gold nanostructures, and their biomedical applications with special reference to cancer studies. [ABSTRACT FROM AUTHOR]

المؤلفون: Krishnamoorthy, Karthikeyan¹, Veerapandian, Murugan^2,3, Yun, Kyusik², Kim, Sang Jae^1,4 kimsangj@jejunu.ac.kr

المصدر: Colloids & Surfaces B: Biointerfaces. Dec2013, Vol. 112, p521-524. 4p.

مصطلحات موضوعية: *FUNCTIONAL groups, *MOLYBDENUM oxides, *NANOSTRUCTURED materials, *PATHOGENIC bacteria, *MICROGRAPHICS, *BIOLOGICAL membranes

مستخلص: Highlights: [•] MoO3 nanoplates were synthesized by chemical precipitation method. [•] XRD and FT-IR studies revealed the orthorhombic phase of MoO3. [•] FE-SEM micrograph revealed the plate-like structure of MoO3. [•] MIC value of MoO3 nanoplates was measured against four pathogenic bacteria. [•] ONPG assay revealed the membrane disruption of Escherichia coli upon MoO3 interaction. [ABSTRACT FROM AUTHOR]

المؤلفون: Venkateswarlu, Sada^1,2 (AUTHOR) venkisada67@gmail.com, Mahajan, Hansa^1,2 (AUTHOR), Panda, Atanu^1,2 (AUTHOR), Lee, Jihyun^1,2 (AUTHOR), Govindaraju, Saravanan³ (AUTHOR), Yun, Kyusik³ (AUTHOR), Yoon, Minyoung¹ (AUTHOR) myyoon@knu.ac.kr

المصدر: Chemical Engineering Journal. Sep2021:Part 2, Vol. 420, pN.PAG-N.PAG. 1p.

مصطلحات موضوعية: *IRON oxides, *ENERGY density, *SUPERCAPACITORS, *GARLIC, *SUPERCAPACITOR electrodes, *FERRIC oxide, *NANOSTRUCTURED materials, *CARBONIZATION

مستخلص: [Display omitted] • The waste garlic husk can act as a carbon (2D-CCS) precursor as well as a solvent. • A novel 0D-Fe 3 O 4 nano assembly and 2D-CCS composite was synthesized with zero-waste generation. • The composite shows outstanding power and energy densities (8000 W kg−1, 115.5 Wh Kg−1) of a supercapacitor. • The 2D crumpled nano-sheet assembly affords high specific capacitance in a supercapacitor application. • This work stimulates a new and universal door converting waste materials to valuable materials. Due to the copious development of industries and depletion of fossil fuels generate deteriorating environmental pollution and appalling economic crisis. Thus, there are increasing unmet for developing well-defined nanostructures to mitigate energy and environmental issues. Herein, we firstly report a unique concerted method to convert agro bio-waste into an economical wealth material. By the inspiration of nature, we selected a waste 2D garlic husk (Allium sativum) as a torchbearer to make a unique material. The garlic extract was applied for the synthesis of Fe 3 O 4 NAs@2D-CCS composite nano-assemblies (NAs). Interestingly, the small-sized Fe 3 O 4 nanocrystals (<20 nm) underwent nucleation in the presence of biogenic 2D-CCS and formed a pomegranate like a cluster (200 nm) forming a conglomerate on porous carbon layers. Most importantly, no secondary waste was generated in this work. This Fe 3 O 4 NAs@2D-CCS composite affords high specific capacitance of 820F g−1 at a current density of 0.5 A g−1, which is nearly 5 to 3 times higher than pristine Fe 3 O 4 NPs (<20 nm) electrode with an outstanding power density (3500–8000 W kg−1) and specific energy density (115.5 to 65.9 Wh Kg−1), which is superior among most of all reported iron oxide and graphitic carbon composites. This simple work stimulates a new door for the generation of waste to well-defined nanostructure materials for energy, catalysis, and environmental applications. [ABSTRACT FROM AUTHOR]