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Daniela Salado-Leza,1,2 Erika Porcel,1 Xiaomin Yang,1 Lenka Štefančíková,1 Marta Bolsa-Ferruz,1 Farah Savina,1 Diana Dragoe,3 Jean-Luc Guerquin-Kern,4 Ting-Di Wu,4 Ryoichi Hirayama,5 Hynd Remita,6 Sandrine Lacombe1 1Université Paris Saclay, CNRS UMR 8214, Institut des Sciences Moléculaires d’Orsay, 91405 Orsay, France; 2Cátedra CONACyT, Faculty of Chemical Sciences, Autonomous University of San Luis Potosí, 78210 San Luis Potosí, Mexico; 3Université Paris Saclay, CNRS UMR 8182, Institut de Chimie Moléculaire et des Matériaux d’Orsay, 91405 Orsay, France; 4Paris-Saclay University, Multimodal Imaging Center (UMS 2016/US 43) CNRS, INSERM, Institut Curie, 91405 Orsay, France; 5Department of Charged Particle Therapy Research, National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology, 263-8555 Chiba, Japan; 6Université Paris Saclay, CNRS UMR 8000, Institut de Chimie Physique, 91405 Orsay, FranceCorrespondence: Sandrine LacombeUniversité Paris-Saclay, CNRS UMR 8214, Institut des Sciences Moléculaires d’Orsay, André Riviére Street, Building 520, Orsay Cedex 91405, FranceTel +33 1 6915 8263Email sandrine.lacombe@universite-paris-saclay.frPurpose: Metal-based nanoparticles (M-NPs) have attracted great attention in nanomedicine due to their capacity to amplify and improve the tumor targeting of medical beams. However, their simple, efficient, high-yield and reproducible production remains a challenge. Currently, M-NPs are mainly synthesized by chemical methods or radiolysis using toxic reactants. The waste of time, loss of material and potential environmental hazards are major limitations.Materials and Methods: This work proposes a simple, fast and green strategy to synthesize small, non-toxic and stable NPs in water with a 100% production rate. Ionizing radiation is used to simultaneously synthesize and sterilize the containing NPs solutions. The synthesis of platinum nanoparticles (Pt NPs) coated with biocompatible poly(ethylene glycol) ligands (PEG) is presented ... |
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