دورية أكاديمية
The minimum clinically important difference (MCID) for a falls intervention in Parkinson's:A delphi study
| العنوان: | The minimum clinically important difference (MCID) for a falls intervention in Parkinson's:A delphi study |
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| المؤلفون: | Henderson, Emily, Morgan, Gemma, Amin, Jigisha, Gaunt, Daisy, Ben-Shlomo, Yoav |
| المصدر: | Henderson , E , Morgan , G , Amin , J , Gaunt , D & Ben-Shlomo , Y 2019 , ' The minimum clinically important difference (MCID) for a falls intervention in Parkinson's : A delphi study ' , Parkinsonism and Related Disorders , vol. 61 , pp. 106-110 . https://doi.org/10.1016/j.parkreldis.2018.11.008Test |
| سنة النشر: | 2019 |
| المجموعة: | University of Bristol: Bristol Reserach |
| مصطلحات موضوعية: | /dk/atira/pure/core/keywords/btc_bristol_trials_centre_, name=BTC (Bristol Trials Centre), /dk/atira/pure/core/keywords/btc_brtc, name=BRTC, /dk/atira/pure/core/keywords/ageing_and_movement_research_group, name=Ageing and Movement Research Group, Parkinson disease, Delphi technique, Falls, Cholinesterase inhibitors, Sample size |
| الوصف: | Background: Falls are common in Parkinson's disease so any intervention that reduced falls risk would be of value. One potential intervention is the use of cholinesterase inhibitor (ChEi) drugs. Objective: To establish the minimum clinically important difference (MCID) for fall rates to inform the effect estimate for sample size calculations of future clinical trials. Methods: We performed a Delphi study assembling a panel of experts in Parkinson's disease from academic and clinical medicine in order to reach a consensus of opinion. Responses from a panel were summarised and resent to the group, until consensus was reached. Results: 780 clinicians, who had been caring for people with Parkinson's for an average of 14 years, were contacted via three routes. The median (Interquartile range (IQR)) MCID after round 1 was 25% (IQR 20–30%) which equates to the prevention of 5 (IQR 4–6) falls per year. Increasing consensus after round two confirmed the MCID of 25%, narrowing the (IQ) range to 20%–25%. This was unchanged when the panel were shown the number of participants that would need to be recruited to a clinical trial in order to achieve this difference. Conclusions: We have established that an expert panel of PD specialists consider that an intervention that demonstrated a 25% (IQR 20–25%) relative reduction in falls rate would be clinically meaningful. This estimate can be used to help determine the sample size for any future clinical trial. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| العلاقة: | https://research-information.bris.ac.uk/en/publications/d0221479-f0fa-4def-b345-2c3a01548195Test |
| DOI: | 10.1016/j.parkreldis.2018.11.008 |
| الإتاحة: | https://doi.org/10.1016/j.parkreldis.2018.11.008Test https://hdl.handle.net/1983/d0221479-f0fa-4def-b345-2c3a01548195Test https://research-information.bris.ac.uk/en/publications/d0221479-f0fa-4def-b345-2c3a01548195Test https://research-information.bris.ac.uk/ws/files/177112215/Henderson_et_al_The_MCID_for_a_falls_intervention_in_Parkinson_s_A_delphi_study.pdfTest http://www.scopus.com/inward/record.url?scp=85056597027&partnerID=8YFLogxKTest |
| حقوق: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.1D51DB2F |
| قاعدة البيانات: | BASE |
| DOI: | 10.1016/j.parkreldis.2018.11.008 |
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