دورية أكاديمية
Exercise training protects human and rodent β cells against endoplasmic reticulum stress and apoptosis
| العنوان: | Exercise training protects human and rodent β cells against endoplasmic reticulum stress and apoptosis |
|---|---|
| المؤلفون: | Paula, Flavia M. M., Leite, Nayara C., Borck, Patricia C., Freitas-Dias, Ricardo, Cnop, Miriam, Chacon-Mikahil, Mara P. T., Cavaglieri, Claudia R., Marchetti, Piero, Boschero, Antonio C., Zoppi, Claudio C., Eizirik, Decio L. |
| المساهمون: | Paula, Flavia M. M., Leite, Nayara C., Borck, Patricia C., Freitas-Dias, Ricardo, Cnop, Miriam, Chacon-Mikahil, Mara P. T., Cavaglieri, Claudia R., Marchetti, Piero, Boschero, Antonio C., Zoppi, Claudio C., Eizirik, Decio L. |
| سنة النشر: | 2018 |
| المجموعة: | ARPI - Archivio della Ricerca dell'Università di Pisa |
| مصطلحات موضوعية: | IL6, Myokine, Pancreatic islet, STAT3, T1D, Biotechnology, Biochemistry, Molecular Biology, Genetics |
| الوصف: | Prolonged exercise has positive metabolic effects in obese or diabetic individuals. These effects are usually ascribed to improvements in insulin sensitivity. We evaluated whether exercise also generates circulating signals that protect human and rodent β cells against endoplasmic reticulum (ER) stress and apoptosis. For this purpose, we obtained serum from humans or mice before and after an 8 wk training period. Exposure of human islets or mouse or rat β cells to human or rodent sera, respectively, obtained from trained individuals reduced cytokine (IL-1β+IFN-γ)- or chemicalERstressor-inducedb-cellERstress andapoptosis, at least inpart via activation of the transcription factor STAT3. These findings indicate that exercise training improves human and rodent β-cell survival under diabetogenic conditions and support lifestyle interventions as a protective approach for both type 1 and 2 diabetes. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | ELETTRONICO |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/29133342; info:eu-repo/semantics/altIdentifier/wos/WOS:000427246000032; volume:32; issue:3; firstpage:1524; lastpage:1536; numberofpages:13; journal:THE FASEB JOURNAL; http://hdl.handle.net/11568/922771Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85043595720 |
| DOI: | 10.1096/fj.201700710R |
| الإتاحة: | https://doi.org/10.1096/fj.201700710RTest http://hdl.handle.net/11568/922771Test |
| رقم الانضمام: | edsbas.EDC98CE2 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1096/fj.201700710R |
|---|