دورية أكاديمية
Macrophages facilitate electrical conduction in the heart
| العنوان: | Macrophages facilitate electrical conduction in the heart |
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| المؤلفون: | Hulsmans, M, Clauss, S, Xiao, L, Aguirre, AD, King, KR, Hanley, A, Hucker, WJ, Wuelfers, EM, Seemann, G, Courties, G, Iwamoto, Y, Sun, Y, Savol, AJ, Sager, HB, Lavine, KJ, Fishbein, GA, Capen, DE, Da Silva, N, Miquerol, L, Wakimoto, H, Seidman, CE, Seidman, JG, Sadreyev, RI, Naxerova, K, Mitchell, RN, Brown, D, Libby, P, Weissleder, R, Swirski, FK, Kohl, P, Vinegoni, C, Milan, DJ, Ellinor, PT, Nahrendorf, M |
| المساهمون: | Commission of the European Communities, British Heart Foundation |
| المصدر: | 522 ; 510 |
| بيانات النشر: | Elsevier |
| سنة النشر: | 2017 |
| المجموعة: | Imperial College London: Spiral |
| مصطلحات موضوعية: | Science & Technology, Life Sciences & Biomedicine, Biochemistry & Molecular Biology, Cell Biology, ATRIOVENTRICULAR NODE, MYOCARDIAL-INFARCTION, CARDIAC MACROPHAGES, TISSUE MACROPHAGES, MEMBRANE CHANNEL, GAP-JUNCTIONS, IMMUNE-SYSTEM, STEADY-STATE, MYOCYTES, CELLS, computational modeling, connexin 43, electrical conduction, gap junctions, heart, macrophages, optogenetics, single-cell RNA-sequencing, tissue clearing, Animals, Female, Heart Atria, Heart Conduction System, Humans, Male, Mice |
| الوصف: | Organ-specific functions of tissue-resident macrophages in the steady-state heart are unknown. Here, we show that cardiac macrophages facilitate electrical conduction through the distal atrioventricular node, where conducting cells densely intersperse with elongated macrophages expressing connexin 43. When coupled to spontaneously beating cardiomyocytes via connexin-43-containing gap junctions, cardiac macrophages have a negative resting membrane potential and depolarize in synchrony with cardiomyocytes. Conversely, macrophages render the resting membrane potential of cardiomyocytes more positive and, according to computational modeling, accelerate their repolarization. Photostimulation of channelrhodopsin-2-expressing macrophages improves atrioventricular conduction, whereas conditional deletion of connexin 43 in macrophages and congenital lack of macrophages delay atrioventricular conduction. In the Cd11bDTR mouse, macrophage ablation induces progressive atrioventricular block. These observations implicate macrophages in normal and aberrant cardiac conduction. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 0092-8674 |
| العلاقة: | Cell; http://hdl.handle.net/10044/1/48423Test; https://dx.doi.org/10.1016/j.cell.2017.03.050Test; 323099; FS/12/17/29532 |
| DOI: | 10.1016/j.cell.2017.03.050 |
| الإتاحة: | https://doi.org/10.1016/j.cell.2017.03.050Test http://hdl.handle.net/10044/1/48423Test |
| حقوق: | © 2017 Elsevier Inc. . All rights reserved. This manuscript is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0Test/ |
| رقم الانضمام: | edsbas.859253BD |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 00928674 |
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| DOI: | 10.1016/j.cell.2017.03.050 |