التفاصيل البيبلوغرافية
| العنوان: |
Therapeutic Use and Molecular Aspects of Ivabradine in Cardiac Remodeling: A Review |
| المؤلفون: |
Yusof Kamisah, Hamat H. Che Hassan |
| المصدر: |
International Journal of Molecular Sciences; Volume 24; Issue 3; Pages: 2801 |
| بيانات النشر: |
Multidisciplinary Digital Publishing Institute |
| سنة النشر: |
2023 |
| المجموعة: |
MDPI Open Access Publishing |
| مصطلحات موضوعية: |
heart failure, left ventricular dysfunction, myocardial fibrosis, cardiac function, cardiac structure |
| جغرافية الموضوع: |
agris |
| الوصف: |
Cardiac remodeling can cause ventricular dysfunction and progress to heart failure, a cardiovascular disease that claims many lives globally. Ivabradine, a funny channel (If) inhibitor, is used in patients with chronic heart failure as an adjunct to other heart failure medications. This review aims to gather updated information regarding the therapeutic use and mechanism of action of ivabradine in heart failure. The drug reduces elevated resting heart rate, which is linked to increased morbidity and mortality in patients with heart failure. Its use is associated with improved cardiac function, structure, and quality of life in the patients. Ivabradine exerts several pleiotropic effects, including an antiremodeling property, which are independent of its principal heart-rate-reducing effects. Its suppressive effects on cardiac remodeling have been demonstrated in animal models of cardiac remodeling and heart failure. It reduces myocardial fibrosis, apoptosis, inflammation, and oxidative stress as well as increases autophagy in the animals. It also modulates myocardial calcium homeostasis, neurohumoral systems, and energy metabolism. However, its role in improving heart failure remains unclear. Therefore, elucidating its molecular mechanisms is imperative and would aid in the design of future studies. |
| نوع الوثيقة: |
text |
| وصف الملف: |
application/pdf |
| اللغة: |
English |
| العلاقة: |
Molecular Pharmacology; https://dx.doi.org/10.3390/ijms24032801Test |
| DOI: |
10.3390/ijms24032801 |
| الإتاحة: |
https://doi.org/10.3390/ijms24032801Test |
| حقوق: |
https://creativecommons.org/licenses/by/4.0Test/ |
| رقم الانضمام: |
edsbas.3ECD1E65 |
| قاعدة البيانات: |
BASE |
