المؤلفون: Akdağlı, Sevtap Arıkan, Azap, Alpay, Demirkazık, Figen Başaran, Hayran, Sibel Aşçıoğlu, Kumbasar, Özlem Özdemir, Metan, Gökhan, Odabaşı, Ekaver, Uzun, Ömrüm, Akan, Hamdi

المساهمون: Uludağ Üniversitesi/Tıp Fakültesi/Mikrobiyoloji Anabilim Dalı., orcid:0000-0002-4803-8206, Ener, Beyza, AAG-8523-2021, 15053025300

مصطلحات موضوعية: Diagnosis, Serology, Imaging, Invasive fungal infection, Beta-d-glucan, Infections, Galactomannan enzyme-immunoassay, Immunocompromised patients, Bronchoalveolar lavage fluid, Blood culture, Linked-immunosorbent-assay, Pulmonary aspergillosis, Joint clinical guidelines, 3. european conference, Hematology, Invasive Aspergillosis, Mycoses, Systemic Mycosis, Antifungal susceptibility, Article, Candida, Computer assisted tomography, Cryptococcal antigen test, Cryptococcosis, Enzyme immunoassay, Fungemia, Fungus culture, Fungus isolation, Fusarium, Hematologic malignancy

الوصف: One of the most problematic issues in hematological malignancies is the diagnosis of invasive fungal diseases. Especially, the difficulty of mycological diagnosis and the necessity of immediate intervention in molds have led to the adoption of "surrogate markers" that do not verify but rather strongly suggest fungal infection. The markers commonly used are galactomannan (GM), beta-glucan, and imaging methods. Although there are numerous studies on these diagnostic approaches, none of these markers serve as a support for the clinician, as is the case in human immunodeficiency virus (HIV) or cytomegalovirus (CMV) infections. This paper has been prepared to explain the diagnostic tests. As molecular tests have not been standardized and are not used routinely in the clinics, they will not be mentioned here.

وصف الملف: application/pdf

العلاقة: Makale - Uluslararası Hakemli Dergi; Türk Hematoloji Dergisi; Yurt içi; Akdağlı, S. A. vd. (2014). "Diagnosis of invasive fungal diseases in hematological malignancies: A critical review of evidence and turkish expert opinion (teo-2)". Türk Hematoloji Dergisi, 31(4), 342-356.; https://jag.journalagent.com/tjh/pdfs/TJH_31_4_342_356.pdfTest; https://hdl.handle.net/11452/39527Test; 000348688800002; 2-s2.0-84924568081; 342; 356; 31; https://doi.org/10.4274/tjh.2014.0218Test

الإتاحة: https://doi.org/10.4274/tjh.2014.0218Test
https://hdl.handle.net/11452/39527Test
https://jag.journalagent.com/tjh/pdfs/TJH_31_4_342_356.pdfTest

العنوان البديل: D-index: Febril Nötropenik Hastalarda İnvazif Mantar Enfeksiyonlarının Tanımlanmasında Yeni Bir Skorlama Sistemi. (Turkish)

المؤلفون: Yılmaz, Gülden, Coşkun, Belgin, Elhan, Atilla, Azap, Alpay, Akan, Hamdi

المصدر: Turkish Journal of Hematology; 2016, Vol. 33 Issue 2, p102-106, 5p

مصطلحات موضوعية: MYCOSES, FEBRILE neutropenia, MYELOID leukemia, RETROSPECTIVE studies, SEVERITY of illness index, HEMATOLOGIC malignancies, DISEASE risk factors

الملخص (بالإنجليزية): Objective: Neutropenia is a critical risk factor for invasive fungal infections (IFIs). We retrospectively performed this study to assess the performance of the D-index, a new test that combines both the duration and the severity of neutropenia, in predicting IFIs among patients with acute myelogenous leukemia. Materials and Methods: Fifteen patients with IFIs and 28 patients who did not develop IFIs were enrolled in the study. The D-index was defined as the area over the neutrophil curve, whereas the cumulative-D-index (c-D-index) was the area over the neutrophil curve from the start of neutropenia until the first clinical manifestation of IFI. Results: The D-index and the c-D-index tended to be significantly higher in patients with IFIs, with medians of 10,150 (range: 4000- 22,000) and 5300 (range: 2300-22,200), respectively (p=0.037 and p=0.003, respectively). The receiver operating characteristic analyses showed that there was a cutoff point of 3875 for the D-index in predicting IFI; the sensitivity, specificity, and positive and negative predictive values were 100%, 67.9%, 35.4%, and 100%, respectively. There was also a cutoff point of 4225 for the c-D-index in predicting IFI; the sensitivity, specificity, and positive and negative predictive values for the c-D-index were 93.3%, 71.4%, 36.6%, and 98.4%. Conclusion: The D-index and especially the c-D-index could be useful tools with high negative predictive value to exclude as well as to predict IFIs in the management of neutropenic patients. [ABSTRACT FROM AUTHOR]

Abstract (Turkish): Amaç: İnvaziv fungal enfeksiyonların (İFE) gelişiminde nötropeni önemli bir risk faktörüdür. Biz bu çalışmayı, akut miyeloid lösemi olup, İFE gelişen hastalarda, nötropeni süresini ve sayısını birlikte değerlendiren yeni bir test olan D-indeks'in performansını ölçmek için geriye dönük olarak yaptık. Gereç ve Yöntemler: Çalışmaya 50 tane İFE gelişen hasta, 28 tane İFE gelişmeyen hasta alındı. D-indeks nötrofil eğrisinin üzerinde kalan alan olarak, kümülatif-D-indeks (k-D-indeks) ise, nötropeninin ilk başladığı günden İFE'nin belirtilerinin başladığı ilk güne kadar çizilen nötrofil eğrisinin üzerinde kalan alan olarak belirlendi. Bulgular: D-indeks ve k-D-indeks İFE gelişen hastalarda yüksek olma eğilimindedir. D-indeks ve k-D-indeks için değerler ortalama 10,150 (aralık: 4000-22,000) ve 5300 (aralık: 2300-22,200) olup, sırası ile p=0,037 ve p=0,003 saptandı. Yapılan analizlerde D-indeks için eşik değerin 3875 olup, duyarlılık, özgüllük, pozitif ve negatif prediktif değerleri sırası ile %100, %67,9, %35,4 ve %100 saptandı. k-D-index için eşik değer 4225 olup, duyarlılık, özgüllük, pozitif ve negatif prediktif değeri sırası ile %93,3, %71,4, %36,6 ve %98,4 saptandı. Sonuç: D-indeks ve özellikle k-D-indeks nötropenik hastaları günlük değerlendirmede kullanılabilecek bir testtir. Negatif prediktif değerinin yüksek olması nedeni ile İFE olan hastaları erken yakalamanın yanı sıra, İFE'yi dışlamak için de etkili bulunmuştur. [ABSTRACT FROM AUTHOR]

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