دورية أكاديمية
Hidden myelodysplastic syndrome (MDS): A prospective study to confirm or exclude MDS in patients with anemia of uncertain etiology
| العنوان: | Hidden myelodysplastic syndrome (MDS): A prospective study to confirm or exclude MDS in patients with anemia of uncertain etiology |
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| المؤلفون: | Bastida, José María, López‐Godino, Oriana, Vicente‐Sánchez, Ana, Bonanad‐Boix, Santiago, Xicoy‐Cirici, Blanca, Hernandez-Sánchez, Jesus M., Such, Esperanza, Cervera, José, Caballero‐Berrocal, Juan C., López Cadenas, Félix, Arnao‐Herráiz, Mario, Rodríguez, Inés, Llopis‐Calatayud, Inmaculada, Jiménez, María J., Cañizo, María Consuelo del, Díez-Campelo, María |
| المساهمون: | Centro de Investigación Biomédica en Red Cáncer (España), Instituto de Salud Carlos III |
| بيانات النشر: | John Wiley & Sons Blackwell Publishing |
| سنة النشر: | 2019 |
| المجموعة: | Digital.CSIC (Consejo Superior de Investigaciones Científicas / Spanish National Research Council) |
| مصطلحات موضوعية: | Anemia, Hemogram, Macrocytosis, Mutation analysis, Myelodysplastic syndrome |
| الوصف: | [Introduction]: Diagnosis of myelodysplastic syndromes (MDSs) when anemia is the only abnormality can be complicated. The aim of our study was to investigate the primary causes of anemia and/or macrocytosis of uncertain etiology. [Methods]: We conducted a multicenter, prospective study over 4 months in three hematology laboratories. In step 1, we used an automated informatics system to screen 137 453 hemograms for cases of anemia and/or macrocytosis (n = 2702). In step 2, we excluded all patients whose anemia appeared to be due to a known cause. This left 290 patients had anemia of uncertain etiology. In step 3, we conducted further investigations, including a peripheral blood smear, and analysis of iron, vitamin B12, folate, and thyroid hormone levels. [Results]: A differential diagnosis was obtained in 139 patients (48%). The primary causes of anemia were iron deficiency (n = 59) and megaloblastic anemia (n = 39). In total, 25 hematologic disorders were diagnosed, including 14 patients with MDS (56%). The median age of MDS patients was 80 years, 12 had anemia as an isolated cytopenia, and most (n = 10) had lower‐risk disease (IPSS‐R ≤ 3.5). SF3B1 mutations were most frequent (n = 6) and correlated with the presence of ring sideroblasts (100%) and associated with better prognosis (P = 0.001). [Conclusions]: Our prospective, four‐step approach is an efficient and logical strategy to facilitate the diagnosis of MDS on the basis of unexplained anemia and/or macrocytosis, and may allow the early diagnosis of the most serious causes of anemia. Molecular analysis of genes related to MDS could be a promising diagnostic and prognostic approach. ; This work was also partially financed by the Centro de Investigación Biomédica en Red de Cáncer (CIBERONC), Instituto de Salud Carlos III (ISCIII) (PI 17/01741 from MDC and PI 17/01966 from JMB). |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | unknown |
| تدمد: | 1751-5521 1751-553X |
| العلاقة: | http://dx.doi.org/10.1111/ijlh.12933Test; Sí; International Journal of Laboratory Hematology 41(1): 109-117 (2019); http://hdl.handle.net/10261/203329Test; http://dx.doi.org/10.13039/501100004587Test |
| DOI: | 10.1111/ijlh.12933 |
| DOI: | 10.13039/501100004587 |
| الإتاحة: | https://doi.org/10.1111/ijlh.12933Test https://doi.org/10.13039/501100004587Test http://hdl.handle.net/10261/203329Test |
| حقوق: | none |
| رقم الانضمام: | edsbas.C5A9D644 |
| قاعدة البيانات: | BASE |
| تدمد: | 17515521 1751553X |
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| DOI: | 10.1111/ijlh.12933 |