يعرض 1 - 10 نتائج من 571 نتيجة بحث عن '"egfr inhibitors"', وقت الاستعلام: 1.50s تنقيح النتائج
  1. 1
    دورية أكاديمية
    Monitoring of RAS mutant clones in plasma of patients with RAS mutant metastatic colorectal cancer.

    المؤلفون: Fernández Montes, A, Élez, E, Vivancos, A, Martínez, N, González, P, Covela, M, de la Cámara, J, Cousillas, A, Méndez, J C, Graña, B, Aranda, E

    مصطلحات موضوعية: Circulating tumor DNA, EGFR inhibitors, Liquid biopsy, Metastatic colorectal cancer, RAS mutant, Antineoplastic Combined Chemotherapy Protocols, Clone Cells, Colonic Neoplasms, Colorectal Neoplasms, Fluorouracil, Humans, Mutation, Panitumumab

    وصف الملف: application/pdf

    العلاقة: http://hdl.handle.net/10668/21019Test; PMC9107427; https://link.springer.com/content/pdf/10.1007/s12094-021-02767-7.pdfTest; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9107427/pdfTest

    الإتاحة: https://doi.org/10.1007/s12094-021-02767-7Test
    http://hdl.handle.net/10668/21019Test
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9107427/pdfTest

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  2. 2
    Structure-activity exploration of a small-molecule allosteric inhibitor of T790M/L858R double mutant EGFR

    المؤلفون: Francesca Foschi, Annachiara Tinivella, Valentina Crippa, Luca Pinzi, Luca Mologni, Daniele Passarella, Giulio Rastelli

    المصدر: Journal of Enzyme Inhibition and Medicinal Chemistry. 38:239-245

    مصطلحات موضوعية: Pharmacology, Lung Neoplasms, Antineoplastic Agents, General Medicine, ErbB Receptors, Structure-Activity Relationship, Drug Resistance, Neoplasm, Carcinoma, Non-Small-Cell Lung, Cell Line, Tumor, Mutation, Drug Discovery, allosteric inhibitors, anticancer drugs, drug design, EGFR inhibitors, Humans, Protein Kinase Inhibitors

    الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9cda021b85828a0573d4727171f3d55Test
    https://doi.org/10.1080/14756366.2022.2145284Test


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  3. 3
    A Novel Third-generation EGFR Tyrosine Kinase Inhibitor Abivertinib for EGFR T790M-mutant Non–Small Cell Lung Cancer: a Multicenter Phase I/II Study

    المؤلفون: Qing Zhou, Lin Wu, Pei Hu, Tongtong An, Jianying Zhou, Li Zhang, Xiao-Qing Liu, Feng Luo, Xin Zheng, Ying Cheng, Nong Yang, Junling Li, Jifeng Feng, Baohui Han, Yong Song, Kai Wang, Jian Fang, Hong Zhao, Yongqian Shu, Xiao-Yan Lin, Zhihong Chen, Bin Gan, Wan-Hong Xu, Wei Tang, Xiaoying Zhang, Jin-Ji Yang, Xiao Xu, Yi-Long Wu

    المصدر: Clinical Cancer Research. 28:1127-1135

    مصطلحات موضوعية: Adult, Cancer Research, medicine.medical_specialty, Lung Neoplasms, EGFR T790M, Gastroenterology, Pharmacokinetics, Carcinoma, Non-Small-Cell Lung, Internal medicine, Humans, Point Mutation, Medicine, Clinical efficacy, Lung cancer, Protein Kinase Inhibitors, EGFR inhibitors, business.industry, medicine.disease, Third generation, ErbB Receptors, Pyrimidines, Oncology, Mutation, Non small cell, business, Egfr tyrosine kinase

    الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ef172334327b78f078f2ebc1a309df2Test
    https://doi.org/10.1158/1078-0432.ccr-21-2595Test


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  4. 4
    Cetuximab resistance induced by hepatocyte growth factor is overcome by MET inhibition in KRAS, NRAS, and BRAF wild-type colorectal cancers

    المؤلفون: Kui-Jin Kim, Soo Mee Bang, Yu Jung Kim, Milang Nam, Ji Won Kim, Jin Won Kim, Ji Hea Sung, Ju Hyun Lee, Hyejoo Park, Jee Hyun Kim, Koung Jin Suh, Sang-A Kim, Eun Hee Jung, Ji Yun Lee, Jong Seok Lee, Keun-Wook Lee, Jeong Ok Lee, Se Hyun Kim

    المصدر: Journal of Cancer Research and Clinical Oncology. 148:2995-3005

    مصطلحات موضوعية: Proto-Oncogene Proteins B-raf, Neuroblastoma RAS viral oncogene homolog, Cancer Research, Colorectal cancer, Cetuximab, medicine.disease_cause, GTP Phosphohydrolases, Proto-Oncogene Proteins p21(ras), Antineoplastic Combined Chemotherapy Protocols, medicine, Humans, neoplasms, EGFR inhibitors, Hepatocyte Growth Factor, Triazines, business.industry, Imidazoles, Membrane Proteins, General Medicine, medicine.disease, digestive system diseases, Bevacizumab, ErbB Receptors, Oncology, Benzamides, Mutation, Cancer research, FOLFIRI, Biomarker (medicine), Hepatocyte growth factor, KRAS, Caco-2 Cells, Colorectal Neoplasms, business, Proto-Oncogene Proteins c-akt, medicine.drug

    الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c70a62d8a3145d10f53940b1ad0da76fTest
    https://doi.org/10.1007/s00432-021-03872-4Test


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  5. 5
    EGFR inhibitors plus bevacizumab are superior than EGFR inhibitors alone as first-line setting in advanced NSCLC with EGFR mutations and BIM deletion polymorphisms (BIM-CLICaP)

    المؤلفون: Tatiana Gamez, Carlos Vargas, Christian Rolfo, Pilar Archila, Luis Corrales, Oscar Arrieta, Claudio Martin, Jorge Otero, C. Sotelo, Hernán Carranza, Juan Esteban Garcia-Robledo, D. Mayorga, Luisa Ricaurte, Camila Ordóñez-Reyes, Lucia Zatarain Barron, L. Rojas, Rafael Rosell, Luis Mas, Alejandro Ruiz-Patiño, Maritza Bermudez, July Rodriguez, J. Ávila, Andrés F. Cardona, Gonzalo Recondo, Feliciano Barrón

    المساهمون: Cardona, Andrés Felipe [0000-0003-3525-4126], Garcia-Robledo, Juan Esteban [0000-0003-2912-152X]

    المصدر: Repositorio U. El Bosque
    Universidad El Bosque
    instacron:Universidad El Bosque

    مصطلحات موضوعية: Adult, Male, 0301 basic medicine, Cancer Research, Lung Neoplasms, Bevacizumab, First line, Pacientes con receptor del factor de crecimiento epidérmico (EGFR), Patients with epidermal growth factor receptor (EGFR), Young Adult, 03 medical and health sciences, Antineoplastic Agents, Immunological, 0302 clinical medicine, harboring BIM deletion polymorphism (BIM deletion), Carcinoma, Non-Small-Cell Lung, medicine, Humans, mutated non–small-cell lung cancer (NSCLC), Epidermal growth factor receptor, Lung cancer, Aged, Neoplasm Staging, Retrospective Studies, EGFR inhibitors, Polimorfismo de eliminación BIM (eliminación BIM), Polymorphism, Genetic, Bcl-2-Like Protein 11, biology, business.industry, Kinase, Middle Aged, medicine.disease, respiratory tract diseases, ErbB Receptors, Drug Combinations, 030104 developmental biology, Oncology, Apoptosis, Egfr mutation, 030220 oncology & carcinogenesis, Mutation, Cancer research, biology.protein, Female, business, Gene Deletion, Cáncer de pulmón de células no pequeñas (CPCNP) mutado, medicine.drug

    وصف الملف: application/pdf

    الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f368f60a7559c0ff0c3e0f742a7de86eTest
    https://doi.org/10.1200/po.20.00404Test


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  6. 6
    Synergistic cytotoxicity of the CDK4 inhibitor Fascaplysin in combination with EGFR inhibitor Afatinib against Non-small Cell Lung Cancer

    المؤلفون: Barbara Rath, Adelina Plangger, Christoph Neumayer, Maximilian Hochmair, Gerhard Hamilton, Martin Funovics, Robert Zeillinger

    المصدر: Investigational New Drugs. 40:215-223

    مصطلحات موضوعية: Indoles, Lung Neoplasms, Afatinib, medicine.medical_treatment, Hyperphosphorylation, Antineoplastic Agents, Western blot, Carcinoma, Non-Small-Cell Lung, medicine, Humans, Pharmacology (medical), Cytotoxicity, Lung cancer, Protein Kinase Inhibitors, EGFR inhibitors, Pharmacology, Cisplatin, Chemotherapy, medicine.diagnostic_test, Chemistry, Cyclin-Dependent Kinase 4, medicine.disease, respiratory tract diseases, ErbB Receptors, Oncology, Mutation, Cancer research, medicine.drug

    الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5312003ab72143a38194d617fd6188ecTest
    https://doi.org/10.1007/s10637-021-01181-8Test


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  7. 7
    Membrane-Associated RING-CH 8 Functions as a Novel PD-L1 E3 Ligase to Mediate PD-L1 Degradation Induced by EGFR Inhibitors

    المؤلفون: Wenyi Wei, Songqing Fan, Guoqing Qian, Karin A. Vallega, Qiming Wang, Yunfu Deng, Zhen Chen, Suresh S. Ramalingam, Jianping Guo, Taofeek K. Owonikoko, Changjiang Hu, Shi-Yong Sun

    المصدر: Mol Cancer Res

    مصطلحات موضوعية: Cancer Research, Lung Neoplasms, Ubiquitin-Protein Ligases, Mice, Nude, Apoptosis, B7-H1 Antigen, Article, Cell Line, Glycogen Synthase Kinase 3, Mice, Ubiquitin, Carcinoma, Non-Small-Cell Lung, Cell Line, Tumor, PD-L1, Animals, Humans, Osimertinib, Epidermal growth factor receptor, Protein Kinase Inhibitors, Molecular Biology, EGFR inhibitors, Acrylamides, Gene knockdown, Aniline Compounds, biology, Chemistry, Ubiquitin ligase, ErbB Receptors, Gene Expression Regulation, Neoplastic, HEK293 Cells, Oncology, Mutation, Cancer cell, biology.protein, Cancer research, Signal Transduction

    الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49618826ca7fd0d978235270c398bde2Test
    https://doi.org/10.1158/1541-7786.mcr-21-0147Test


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  8. 8
    Targeting more precisely: Improving sensitivity to EGFR inhibitors in NSCLC

    المؤلفون: Arjan Gower, Edward B. Garon

    المصدر: Nature

    مصطلحات موضوعية: Lung Neoplasms, biology, business.industry, General Medicine, Article, respiratory tract diseases, ErbB Receptors, Targeted therapies, Egfr mutation, Carcinoma, Non-Small-Cell Lung, Mutation, Cancer research, biology.protein, Medicine, Humans, Non small cell, Epidermal growth factor receptor, business, Protein Kinase Inhibitors, Non-small-cell lung cancer, EGFR inhibitors

    الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6cfcb72bd1a33c72e3ba4014c9c4703Test
    https://pubmed.ncbi.nlm.nih.gov/34526717Test


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  9. 9
    The Clinical Impact of Quantitative Cell-free DNA, KRAS, and BRAF Mutations on Response to Anti-EGFR Treatment in Patients with Metastatic Colorectal Cancer

    المؤلفون: Reyhaneh Moradi-Marjaneh, Elnaz Khordad, Fereshteh Asgharzadeh, Mahdi Moradi Marjaneh

    المصدر: Current Pharmaceutical Design. 27:942-952

    مصطلحات موضوعية: Proto-Oncogene Proteins B-raf, Oncology, medicine.medical_specialty, Class I Phosphatidylinositol 3-Kinases, Colorectal cancer, medicine.disease_cause, Proto-Oncogene Proteins p21(ras), Causes of cancer, Internal medicine, Drug Discovery, Biomarkers, Tumor, medicine, Humans, In patient, EGFR inhibitors, Pharmacology, business.industry, Cancer, medicine.disease, digestive system diseases, Circulating Cell-Free DNA, Cell-free fetal DNA, Mutation, KRAS, Colorectal Neoplasms, business, Cell-Free Nucleic Acids

    الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a93b8d787be72ab8653d8483ad2bcaedTest
    https://doi.org/10.2174/1381612826666201007163116Test


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  10. 10
    Single-cell transcriptional changes associated with drug tolerance and response to combination therapies in cancer

    المؤلفون: Alexandra E. Rader, Carlota Rubio-Perez, Maxim V. Frolov, Mary Pasquinelli, Majd M. Ariss, Ryan D. Conrardy, Abul B. M. M. K. Islam, Alexa M. Gajda, Lawrence Eric Feldman, Cammille C. Go, Stefan J. Green, Alexandre Ferro Aissa, Elizaveta V. Benevolenskaya, Nuria Lopez-Bigas, Klara Valyi-Nagy

    المصدر: Nature Communications, Vol 12, Iss 1, Pp 1-25 (2021)
    Nature Communications

    مصطلحات موضوعية: 0301 basic medicine, Epithelial-Mesenchymal Transition, Cancer therapy, Cell Survival, Science, General Physics and Astronomy, Antineoplastic Agents, Drug resistance, Biology, Article, General Biochemistry, Genetics and Molecular Biology, Receptor tyrosine kinase, Gene regulatory networks, 03 medical and health sciences, 0302 clinical medicine, Drug tolerance, Cell Line, Tumor, Neoplasms, Drug Discovery, medicine, Humans, Cancer models, Protein Kinase Inhibitors, EGFR inhibitors, Multidisciplinary, Crizotinib, Drug discovery, Receptor Protein-Tyrosine Kinases, Drug Tolerance, U937 Cells, General Chemistry, respiratory tract diseases, ErbB Receptors, Gene Expression Regulation, Neoplastic, Drug Combinations, Cholesterol, 030104 developmental biology, Drug Resistance, Neoplasm, 030220 oncology & carcinogenesis, Mutation, Cancer research, biology.protein, Heterografts, Vesicle-mediated transport, Tyrosine kinase, medicine.drug

    الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5567cf379b66251833dd58cf46aa6c95Test
    https://doaj.org/article/07bdc3f7e13d4e018edb5f1887d9c903Test


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