يعرض 81 - 90 نتائج من 571 نتيجة بحث عن '"egfr inhibitors"', وقت الاستعلام: 0.84s تنقيح النتائج
  1. 81
    Structural modifications on indole and pyrimidine rings of osimertinib lead to high selectivity towards L858R/T790M double mutant enzyme and potent antitumor activity

    المؤلفون: Luo Yanli, Lei Fang, Li Zerui, Chen Chen, Qiao Liu

    المصدر: Bioorganicmedicinal chemistry. 36

    مصطلحات موضوعية: Indoles, Pyrimidine, Clinical Biochemistry, Pharmaceutical Science, Antineoplastic Agents, 01 natural sciences, Biochemistry, chemistry.chemical_compound, T790M, Structure-Activity Relationship, In vivo, Drug Discovery, Tumor Cells, Cultured, Humans, Osimertinib, Molecular Biology, Protein Kinase Inhibitors, EGFR inhibitors, Cell Proliferation, Indole test, Acrylamides, Aniline Compounds, Dose-Response Relationship, Drug, Molecular Structure, 010405 organic chemistry, Organic Chemistry, In vitro, 0104 chemical sciences, ErbB Receptors, Molecular Docking Simulation, 010404 medicinal & biomolecular chemistry, Pyrimidines, chemistry, Mutation, Molecular Medicine, Drug Screening Assays, Antitumor, Lead compound

    الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27906a9eee1cc5c503471541fcf70f30Test
    https://pubmed.ncbi.nlm.nih.gov/33667898Test


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  2. 82
    IMPACT OF KRAS MUTATIONS IN CLINICAL FEATURES IN COLORECTAL CANCER

    المؤلفون: Adauto Nunes, Renato Morato Zanatto, Sarhan Sydney Saad, Eduardo Pracucho, SARHAN SYDNEY SAAD, Gaspar De Jesus Lopes Filho, Junea Oliveira, Gianni Mara Silva Santos

    المصدر: Arquivos Brasileiros de Cirurgia Digestiva : ABCD
    ABCD. Arquivos Brasileiros de Cirurgia Digestiva (São Paulo) v.33 n.3 2020
    ABCD. Arquivos Brasileiros de Cirurgia Digestiva (São Paulo)
    Colégio Brasileiro de Cirurgia Digestiva (CBCD)
    instacron:CBCD
    ABCD. Arquivos Brasileiros de Cirurgia Digestiva (São Paulo), Volume: 33, Issue: 3, Article number: e1524, Published: 16 DEC 2020
    ABCD: Arquivos Brasileiros de Cirurgia Digestiva, Vol 33, Iss 3 (2020)

    مصطلحات موضوعية: 0301 basic medicine, Oncology, Adult, Male, medicine.medical_specialty, Neoplasias colorretais, RD1-811, Colorectal cancer, RC799-869, Disease, medicine.disease_cause, Colorectal neoplasms, Proto-Oncogene Proteins p21(ras), 03 medical and health sciences, Exon, 0302 clinical medicine, Internal medicine, Proto-Oncogene Proteins, Medicine, Humans, Allele frequency, Mutação, EGFR inhibitors, Aged, Retrospective Studies, Aged, 80 and over, business.industry, General Medicine, Diseases of the digestive system. Gastroenterology, Middle Aged, medicine.disease, Primary tumor, Gene frequency, digestive system diseases, 030104 developmental biology, 030220 oncology & carcinogenesis, Mutation (genetic algorithm), Mutation, ras Proteins, Surgery, Original Article, Female, KRAS, business, Frequência do gene

    وصف الملف: text/html

    الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb8766879a94cfa443953bb40383df50Test
    http://europepmc.org/articles/PMC7743328Test


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  3. 83
    Allosteric mutant-selective fourth-generation EGFR inhibitors as an efficient combination therapeutic in the treatment of non-small cell lung carcinoma

    المؤلفون: Surya Kant Tripathi, Bijesh K. Biswal

    المصدر: Drug discovery today. 26(6)

    مصطلحات موضوعية: 0301 basic medicine, Drug, Lung Neoplasms, media_common.quotation_subject, Allosteric regulation, Mutant, Cell, 03 medical and health sciences, T790M, 0302 clinical medicine, Allosteric Regulation, Carcinoma, Non-Small-Cell Lung, Drug Discovery, Antineoplastic Combined Chemotherapy Protocols, Carcinoma, medicine, Animals, Humans, Protein Kinase Inhibitors, media_common, EGFR inhibitors, Pharmacology, Lung, business.industry, Drug Synergism, medicine.disease, respiratory tract diseases, ErbB Receptors, 030104 developmental biology, medicine.anatomical_structure, Drug Resistance, Neoplasm, 030220 oncology & carcinogenesis, Mutation, Cancer research, Immunotherapy, business

    الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a9feb11b33a5638415eac988935b951Test
    https://pubmed.ncbi.nlm.nih.gov/33581322Test


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  4. 84
    Discernment between candidate mechanisms for KRAS G13D colorectal cancer sensitivity to EGFR inhibitors

    المؤلفون: Noah K Schomburg, Edward C. Stites, Kent L. Rossman, Thomas McFall

    المصدر: Cell Communication and Signaling : CCS
    Cell Communication and Signaling, Vol 18, Iss 1, Pp 1-7 (2020)

    مصطلحات موضوعية: Neuroblastoma RAS viral oncogene homolog, endocrine system diseases, Colorectal cancer, medicine.medical_treatment, lcsh:Medicine, medicine.disease_cause, Biochemistry, Targeted therapy, 0302 clinical medicine, Fluorescence Resonance Energy Transfer, EGFR inhibitors, Cancer, 0303 health sciences, Neurofibromin 1, Cetuximab, lcsh:Cytology, ErbB Receptors, 030220 oncology & carcinogenesis, KRAS, Colorectal Neoplasms, medicine.drug, Protein Binding, EGFR, Short Report, Biology, Biophysical Phenomena, Proto-Oncogene Proteins p21(ras), 03 medical and health sciences, medicine, Humans, HRAS, lcsh:QH573-671, Molecular Biology, neoplasms, GTPase, Protein Kinase Inhibitors, 030304 developmental biology, lcsh:R, Cell Biology, medicine.disease, HCT116 Cells, digestive system diseases, respiratory tract diseases, HEK293 Cells, Mutation, Cancer research, Mutant Proteins

    الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85e430e3a0d96b96a00a5d8206bceee4Test
    http://europepmc.org/articles/PMC7643456Test


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  5. 85
    Small Molecule Destabilizer of β-Catenin and Ras Proteins Antagonizes Growth of K-Ras Mutation-Driven Colorectal Cancers Resistant to EGFR Inhibitors

    المؤلفون: Byoung-San Moon, Heeyeong Cho, Jung Kyu Choi

    المصدر: Targeted oncology. 15(5)

    مصطلحات موضوعية: 0301 basic medicine, Cancer Research, Colorectal cancer, 03 medical and health sciences, Mice, 0302 clinical medicine, Cell Line, Tumor, Medicine, Animals, Humans, Pharmacology (medical), beta Catenin, EGFR inhibitors, business.industry, Wnt signaling pathway, Cancer, medicine.disease, Neural stem cell, ErbB Receptors, 030104 developmental biology, Oncology, Apoptosis, Cell culture, 030220 oncology & carcinogenesis, Catenin, Mutation, Cancer research, ras Proteins, business, Colorectal Neoplasms

    الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::772260921d255efa21c1d936c99588a3Test
    https://pubmed.ncbi.nlm.nih.gov/33026592Test


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  6. 86
    Clinical Benefit of Tyrosine Kinase Inhibitors in Advanced Lung Cancer with EGFR‐G719A and Other Uncommon EGFR Mutations

    المؤلفون: Susumu Kobayashi, Paul A. VanderLaan, Deepa Rangachari, Kartik Sehgal, Daniel B. Costa

    المصدر: Oncologist

    مصطلحات موضوعية: 0301 basic medicine, Oncology, Cancer Research, medicine.medical_specialty, Lung Neoplasms, Afatinib, Population, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, Carcinoma, Non-Small-Cell Lung, Republic of Korea, medicine, Humans, Osimertinib, Epidermal growth factor receptor, Prospective Studies, Lung cancer, education, Adverse effect, Protein Kinase Inhibitors, EGFR inhibitors, education.field_of_study, biology, business.industry, medicine.disease, ErbB Receptors, 030104 developmental biology, 030220 oncology & carcinogenesis, Mutation, biology.protein, Precision Medicine Clinic: Molecular Tumor Board, Female, business, Tyrosine kinase, medicine.drug

    الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::533a48f7473f885121ecb3a6889b18efTest
    https://europepmc.org/articles/PMC8018319Test/


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  7. 87
    Microsecond-timescale MD simulation of EGFR minor mutation predicts the structural flexibility of EGFR kinase core that reflects EGFR inhibitor sensitivity

    المؤلفون: Kazuma Kishi, Noriko Yanagitani, Ryohei Katayama, Hironori Ninomiya, Mitsugu Araki, Kengo Takeuchi, Shigeyuki Matsumoto, Naoya Fujita, Satoru Kitazono, Sumie Koike, Yasushi Okuno, Makoto Nishio, Biao Ma, Satoshi Takagi, Takahiro Yoshizawa, Ryo Ariyasu, Ryo Kanada, Yosuke Seto, Tomoko Oh-hara, Ken Uchibori

    المصدر: NPJ Precision Oncology
    npj Precision Oncology, Vol 5, Iss 1, Pp 1-11 (2021)

    مصطلحات موضوعية: 0301 basic medicine, Cancer Research, Allosteric regulation, medicine.disease_cause, Article, 03 medical and health sciences, 0302 clinical medicine, Gefitinib, medicine, Protein folding, Lung cancer, Gene, RC254-282, EGFR inhibitors, Mutation, Kinase, Chemistry, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, medicine.disease, respiratory tract diseases, Cancer therapeutic resistance, 030104 developmental biology, Oncology, Drug development, 030220 oncology & carcinogenesis, Cancer research, Non-small-cell lung cancer, medicine.drug

    الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee6b2a0318601d593d6bfc91de98d564Test
    https://pubmed.ncbi.nlm.nih.gov/33863983Test


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  8. 88
    Marked synergy by vertical inhibition of EGFR signaling in NSCLC spheroids shows SOS1 is a therapeutic target in EGFR-mutated cancer

    المؤلفون: Erin Sheffels, Patricia L. Theard, Amanda J Linke, David J Pratico, Nancy E. Sealover, Robert L. Kortum

    المصدر: eLife, Vol 9 (2020)
    eLife

    مصطلحات موضوعية: 0301 basic medicine, Lung Neoplasms, Cell, synergy, Apoptosis, medicine.disease_cause, 0302 clinical medicine, Carcinoma, Non-Small-Cell Lung, Biology (General), Cancer Biology, EGFR inhibitors, Mutation, Aniline Compounds, General Neuroscience, Drug Synergism, General Medicine, ErbB Receptors, medicine.anatomical_structure, 030220 oncology & carcinogenesis, embryonic structures, Medicine, Signal transduction, SOS1 Protein, Research Article, Human, Signal Transduction, Cell type, QH301-705.5, Science, Antineoplastic Agents, spheroids, General Biochemistry, Genetics and Molecular Biology, 03 medical and health sciences, Cell Line, Tumor, Spheroids, Cellular, medicine, Humans, Lung cancer, Cell Proliferation, Acrylamides, General Immunology and Microbiology, business.industry, Cancer, medicine.disease, lung adenocarcinoma, respiratory tract diseases, 030104 developmental biology, HEK293 Cells, Cancer cell, Cancer research, son of sevenless, business

    الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::923e13d693ec617b966f4058f15eb324Test
    https://elifesciences.org/articles/58204Test


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  9. 89
    The new opportunities in medicinal chemistry of fourth-generation EGFR inhibitors to overcome C797S mutation

    المؤلفون: Wufu Zhu, Jie He, Xin Sun, Pengwu Zheng, Zunhua Yang, Zhihui Zhou, Shan Xu

    المصدر: European journal of medicinal chemistry. 210

    مصطلحات موضوعية: Lung Neoplasms, Angiogenesis, medicine.medical_treatment, Chemistry, Pharmaceutical, Antineoplastic Agents, 01 natural sciences, Medicinal chemistry, Metastasis, 03 medical and health sciences, Carcinoma, Non-Small-Cell Lung, Drug Discovery, medicine, Humans, Epidermal growth factor receptor, Receptor, Protein Kinase Inhibitors, 030304 developmental biology, EGFR inhibitors, Cell Proliferation, Pharmacology, 0303 health sciences, biology, Molecular Structure, 010405 organic chemistry, Chemistry, Cell growth, Growth factor, Organic Chemistry, General Medicine, medicine.disease, 0104 chemical sciences, ErbB Receptors, Apoptosis, Mutation, biology.protein

    الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::859d0483ad00f4cc7a07f07bb4c9badaTest
    https://pubmed.ncbi.nlm.nih.gov/33243531Test


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  10. 90
    Clinical impact of uncommon epidermal growth factor receptor exon 19 insertion-deletion variants on epidermal growth factor receptor-tyrosine kinase inhibitor efficacy in non-small-cell lung cancer

    المؤلفون: Xinru Mao, Xingzhou Peng, Qinqin Xu, Nong Yang, Yongchang Zhang, Xiaoyan Long, Dehua Liao, Kunyan Li, Li Liu, Analyn Lizaso, Wenjuan Jiang, Jing Wang, Haiyan Yang, Liang Zeng, Aaron S. Mansfield

    المصدر: European journal of cancer (Oxford, England : 1990). 141

    مصطلحات موضوعية: 0301 basic medicine, Oncology, Adult, Male, Cancer Research, medicine.medical_specialty, Lung Neoplasms, Antineoplastic Agents, 03 medical and health sciences, Exon, T790M, 0302 clinical medicine, Internal medicine, Carcinoma, Non-Small-Cell Lung, medicine, Humans, Osimertinib, Epidermal growth factor receptor, Lung cancer, Protein Kinase Inhibitors, EGFR inhibitors, Aged, Aged, 80 and over, Acrylamides, Aniline Compounds, biology, business.industry, Middle Aged, medicine.disease, Progression-Free Survival, ErbB Receptors, 030104 developmental biology, Drug Resistance, Neoplasm, 030220 oncology & carcinogenesis, Propensity score matching, Mutation, biology.protein, Female, business, Epidermal growth factor receptor tyrosine kinase

    الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1211d89ea33e05b7fa052d3386d203c6Test
    https://pubmed.ncbi.nlm.nih.gov/33171317Test


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