التفاصيل البيبلوغرافية
| العنوان: |
Autologous stem cell transplant for early relapsed/refractory Hodgkin lymphoma: results from two transplant centres. |
| المؤلفون: |
Smith, Stephen D., Moskowitz, Craig H., Dean, Robert, Pohlman, Brad, Sobecks, Ronald, Copelan, Edward, Andresen, Steven, Bolwell, Brian, Maragulia, Jocelyn C., Vanak, Jill M., Sweetenham, John, Moskowitz, Alison J. |
| المصدر: |
British Journal of Haematology; May2011, Vol. 153 Issue 3, p358-363, 6p, 3 Charts, 2 Graphs |
| مصطلحات موضوعية: |
HODGKIN'S disease, DISEASE relapse, PROGNOSIS, STEM cell transplantation, MULTIVARIATE analysis |
| مستخلص: |
Prior series have demonstrated that early relapsed (within 1 year) or refractory Hodgkin lymphoma (HL) is associated with poor prognosis. To determine the outcome for patients with early relapsed/refractory HL in the modern era, we combined data from two large transplant centres, Cleveland Clinic Taussig Cancer Institute (CCTCI) and Memorial Sloan-Kettering Cancer Center (MSKCC), and analysed consecutive patients transplanted for relapsed/refractory HL following induction failure or remission durations of <1 year. Two hundred and fourteen patients were analysed and the event-free survival (EFS) and overall survival (OS) at 6 years for all patients were 45% and 55%, respectively. Factors significant for prognosis in multivariate analysis were extranodal disease and bulky disease (≥5 cm). Patients with 0, 1, or 2 risk factors achieved 6 year EFS of 65%, 47%, and 24% and 6 year OS of 81%, 55%, and 27%, respectively. Patients with the sole risk factor of early relapsed/refractory disease achieved good outcomes in this large series; however the presence of bulk and/or extranodal disease significantly reduced EFS and OS. Patients with these additional risk factors are best suited for clinical trials investigating novel salvage regimens and post-transplant maintenance strategies. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
