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1Intrinsically disordered substrates dictate SPOP subnuclear localization and ubiquitination activity
المؤلفون: Amie K. Boal, Scott A. Showalter, Nafiseh Sabri, Roman Rohac, Emery T. Usher, Tanja Mittag
المصدر: The Journal of Biological Chemistry
مصطلحات موضوعية: 0301 basic medicine, Models, Molecular, endocrine system diseases, SBM1, SB motif 1, Amino Acid Motifs, SPOP, Biochemistry, IDRs, intrinsically disordered regions, PBST, Triton X-100 in PBS, Ubiquitin, Pdx1, biology, diabetes, FA, fluorescence anisotropy, Nuclear Proteins, Editors' Pick, multivalency, MATH, meprin and tumor necrosis factor receptor-associated factor homology, Ubiquitin ligase, Cell biology, LLPS, liquid–liquid phase separation, Protein Transport, Ni-NTA, nickel-nitrilotriacetic acid, PDX1, SBM2, SB motif 2, Protein Binding, Research Article, DAXX, death domain-associated protein 6, SPOP, speckle-type POZ protein, endocrine system, ubiquitination, digestive system, 03 medical and health sciences, Death-associated protein 6, Humans, structure, Molecular Biology, Transcription factor, Puc, puckered protein, Homeodomain Proteins, Nucleoplasm, 030102 biochemistry & molecular biology, Cell Biology, Repressor Proteins, 030104 developmental biology, SB, SPOP-binding, biology.protein, Trans-Activators, Homeobox, AR, androgen receptor, Pdx1, pancreatic and duodenal homeobox 1, DAPI, 4′,6-diamidino-2-phenylindole
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::865b2261c9773bb5532b2ebeb6469bacTest
https://pubmed.ncbi.nlm.nih.gov/33894201Test -
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المؤلفون: Christy R. Grace, Jihun Lee, Junmin Peng, Melissa R. Marzahn, Amanda Nourse, Tanja Mittag, Edmond R. Watson, Anthony A. High, Wendy K. Pierce, Brenda A. Schulman
المصدر: Journal of Molecular Biology. 428(6):1256-1271
مصطلحات موضوعية: 0301 basic medicine, Ubiquitin-Protein Ligases, Amino Acid Motifs, Plasma protein binding, SPOP, Article, 03 medical and health sciences, NMR spectroscopy, Ubiquitin, Structural Biology, cancer, Animals, Short linear motif, Speckle-type POZ protein, Molecular Biology, chemistry.chemical_classification, DNA ligase, biology, Ubiquitination, Processivity, multivalency, degron, Ubiquitin ligase, Cell biology, 030104 developmental biology, Biochemistry, chemistry, Hedgehogs, biology.protein, Degron, Protein Binding, Transcription Factors
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12958f008244d5d2c06bc515281da419Test