دورية أكاديمية
Infection with Burkholderia pseudomallei - immune correlates of survival in acute melioidosis
| العنوان: | Infection with Burkholderia pseudomallei - immune correlates of survival in acute melioidosis |
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| المؤلفون: | Dunachie, SJ, Jenjaroen, K, Reynolds, CJ, Quigley, KJ, Sergeant, R, Sumonwiriya, M, Chaichana, P, Chumseng, S, Ariyaprasert, P, Lassaux, P, Gourlay, L, Promwong, C, Teparrukkul, P, Limmathurotsakul, D, Day, NPJ, Altmann, DM, Boyton, RJ |
| المساهمون: | Welton Foundation, National Institutes of Health, Imperial College Healthcare NHS Trust- BRC Funding |
| بيانات النشر: | NATURE PUBLISHING GROUP |
| سنة النشر: | 2017 |
| المجموعة: | Imperial College London: Spiral |
| مصطلحات موضوعية: | Science & Technology, Multidisciplinary Sciences, Science & Technology - Other Topics, T-CELL IMMUNITY, MYCOBACTERIUM-TUBERCULOSIS, CEPACIA COMPLEX, PROTEIN, EPITOPE, PATHOGENESIS, VACCINES, DISEASE, SEPSIS, MODEL |
| الوصف: | Melioidosis, caused by Burkholderia pseudomallei, is a potentially lethal infection with no licensed vaccine. There is little understanding of why some exposed individuals have no symptoms, while others rapidly progress to sepsis and death, or why diabetes confers increased susceptibility. We prospectively recruited a cohort of 183 acute melioidosis patients and 21 control subjects from Northeast Thailand and studied immune parameters in the context of survival status and the presence or absence of diabetes. HLA-B*46 (one of the commonest HLA class I alleles in SE Asia) and HLA-C*01 were associated with an increased risk of death (odds ratio 2.8 and 3.1 respectively). Transcriptomic analysis during acute infection in diabetics indicated the importance of interplay between immune pathways including those involved in antigen presentation, chemotaxis, innate and adaptive immunity and their regulation. Survival was associated with enhanced T cell immunity to nine of fifteen immunodominant antigens analysed including AhpC (BPSL2096), BopE (BPSS1525), PilO (BPSS1599), ATP binding protein (BPSS1385) and an uncharacterised protein (BPSL2520). T cell immunity to GroEL (BPSL2697) was specifically impaired in diabetic individuals. This characterization of immunity associated with survival during acute infection offers insights into correlates of protection and a foundation for design of an effective multivalent vaccine. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 2045-2322 |
| العلاقة: | SCIENTIFIC REPORTS; http://hdl.handle.net/10044/1/53421Test; https://dx.doi.org/10.1038/s41598-017-12331-5Test; N/A; HHSN272200900046C; RDF01 79560 |
| DOI: | 10.1038/s41598-017-12331-5 |
| الإتاحة: | https://doi.org/10.1038/s41598-017-12331-5Test http://hdl.handle.net/10044/1/53421Test |
| حقوق: | © 2017 The Author(s). Open Access. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Cre - ative Commons license, and indicate if changes were made. Th e images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not per - mitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0Test/. |
| رقم الانضمام: | edsbas.81FD9C20 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 20452322 |
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| DOI: | 10.1038/s41598-017-12331-5 |