المؤلفون: Aarno Palotie, Daniel F. Gudbjartsson, Stacy Steinberg, Thorlakur Jonsson, Augustine Kong, Kari Stefansson, Jon Snaedal, Ryan J. Watts, Timothy W. Behrens, Patrick Sulem, Palmi V. Jonsson, Kwame Hoyte, Unnur Thorsteinsdottir, Yichin Liu, Gyda Bjornsdottir, Sigurbjorn Bjornsson, Ole A. Andreassen, Olafur T. Magnusson, Johanna Huttenlocher, Robert R. Graham, Erik G. Jönsson, Amy Gustafson, Janice A. Maloney, Yanmei Lu, Jasvinder K. Atwal, Hreinn Stefansson, Tushar Bhangale

المصدر: Nature. 488:96-99

مصطلحات موضوعية: Aging, Age-related cognitive decline, Plaque, Amyloid, Disease, Amyloid beta-Protein Precursor, 03 medical and health sciences, Cognition, 0302 clinical medicine, Alzheimer Disease, Amyloid precursor protein, Aspartic Acid Endopeptidases, Humans, Medicine, Dementia, Genetic Predisposition to Disease, Cognitive decline, Allele, Gene, Alleles, 030304 developmental biology, 0303 health sciences, Multidisciplinary, biology, business.industry, medicine.disease, HEK293 Cells, Mutation, Immunology, biology.protein, Verubecestat, Amyloid Precursor Protein Secretases, Cognition Disorders, business, 030217 neurology & neurosurgery

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7408df1fc876b3360c1866a2f5d5ee26Test
https://doi.org/10.1038/nature11283Test

المؤلفون: Arsaell Arnarsson, Thorlakur Jonsson, Daniel F. Gudbjartsson, Adalbjorg Jonasdottir, Gudmundur A. Hardarson, Jeffrey R. Gulcher, Kristinn P. Magnusson, Unnur Thorsteinsdottir, Fridbert Jonasson, Hreinn Stefansson, Mehdi Motallebipour, Kari Stefansson, Aslaug Jonasdottir, Augustine Kong, Ola Wallerman, Gudmar Thorleifsson, Gisli Masson, G. Bragi Walters, Claes Wadelius, Gerdur Stefansdottir, H. Petursson, Patrick Sulem

المصدر: Science. 317:1397-1400

مصطلحات موضوعية: Male, Genotype, Population, Iceland, Pseudoexfoliation syndrome, Gene Expression, Glaucoma, Single-nucleotide polymorphism, Biology, Exfoliation Syndrome, Polymorphism, Single Nucleotide, Exon, medicine, Humans, Genetic Predisposition to Disease, Risk factor, education, Genetics, education.field_of_study, Chi-Square Distribution, Multidisciplinary, Haplotype, medicine.disease, eye diseases, Adipose Tissue, Case-Control Studies, Female, Amino Acid Oxidoreductases, Glaucoma, Open-Angle

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d36d1c4f8c42174e6416de6c0ef84eddTest
https://doi.org/10.1126/science.1146554Test

المؤلفون: Carey D. Waldburger, Robert T. Sauer, Thorlakur Jonsson

المصدر: Proceedings of the National Academy of Sciences. 93:2629-2634

مصطلحات موضوعية: Models, Molecular, Protein Folding, Macromolecular Substances, Dimer, Molecular Sequence Data, Glutamic Acid, Calorimetry, Arginine, Protein Structure, Secondary, Hydrophobic effect, Viral Proteins, chemistry.chemical_compound, Urea, Intermediate state, Viral Regulatory and Accessory Proteins, Amino Acid Sequence, Multidisciplinary, Viscosity, Hydrogen bond, Osmolar Concentration, Hydrogen Bonding, DNA-Binding Proteins, Repressor Proteins, Folding (chemistry), Kinetics, Crystallography, Spectrometry, Fluorescence, chemistry, Ionic strength, Mutagenesis, Site-Directed, Protein folding, Salt bridge, Research Article

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5709010c219f252f306628160ac941d6Test
https://doi.org/10.1073/pnas.93.7.2629Test

المؤلفون: Kristleifur Kristjansson, Daniel F. Gudbjartsson, Olof Birna Olafsdottir, Dolores Isla, Andrea Flex, Lambertus A. Kiemeney, Katja K.H. Aben, Valgerdur Runarsdottir, Thorlakur Jonsson, Julius Gudmundsson, Patrick Sulem, Thorarinn Tyrfingsson, Halla Skuladottir, Jona Saemundsdottir, Jon Thor Bergthorsson, Steinunn Thorlacius, Anna Wiste, Gregory T. Jones, Augustine Kong, Jeffrey R. Gulcher, Kristinn P. Magnusson, Kari Stefansson, Frank Geller, Ingunn Hansdottir, Andrei Manolescu, Simon N. Stacey, Andre M. van Rij, Maria Vidal, Peter F.A. Mulders, Hogni Oskarsson, Tomas Gudbjartsson, Unnur Thorsteinsdottir, Thorunn Rafnar, Margret Jakobsdottir, Roberto Pola, Gyda Bjornsdottir, Benjamin Dieplinger, Halldor Kolbeinsson, Hreinn Stefansson, Anders Gottsäter, Larus J. Gudmundsson, Steinn Jonsson, Bengt Lindblad, Helgi J Isaksson, Thorgeir E. Thorgeirsson, Thomas Mueller, Berta Saez, Laura Asín, Andres Ingason, Thorsteinn Blondal, Jón G. Stefánsson, Femmie de Vegt, Meinhard Haltmayer, Gudmar Thorleifsson, L. Murillo, Stefan E Matthiasson, Jose I. Mayordomo

المصدر: Nature, 452, 638-42
Nature, 452, 7187, pp. 638-42

مصطلحات موضوعية: Oncology, medicine.medical_specialty, Population, Aetiology, screening and detection [ONCOL 5], Article, Molecular epidemiology [NCEBP 1], Nicotine, Translational research [ONCOL 3], Internal medicine, Epidemiology, Determinants in Health and Disease [EBP 1], Medicine, Risk factor, education, Lung cancer, Molecular diagnosis, prognosis and monitoring [UMCN 1.2], education.field_of_study, Multidisciplinary, Hereditary cancer and cancer-related syndromes [ONCOL 1], biology, business.industry, CHRNA5, Odds ratio, medicine.disease, Lung cancer susceptibility, biology.protein, business, medicine.drug

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68a99a3f0a3e92be92d14e191de220e2Test
https://doi.org/10.1038/nature06846Test