Expression of L-type amino acid transporter 1 is a poor prognostic factor for Non-Hodgkin’s lymphoma
| العنوان: | Expression of L-type amino acid transporter 1 is a poor prognostic factor for Non-Hodgkin’s lymphoma |
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| المؤلفون: | Atsushi Kurata, Akihiko Gotoh, Masakatsu Takanashi, Masahiko Kuroda, Keiki Oikawa, Jun Matsubayashi, Kohsuke Kanekura, Toshitaka Nagao, Koji Fujita, Daigo Akahane, Narangerel Jigjidkhorloo, Oyundelger Norov, Hitoshi Endou |
| المصدر: | Scientific Reports, Vol 11, Iss 1, Pp 1-15 (2021) Scientific Reports |
| بيانات النشر: | Nature Portfolio, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Adult, Male, Prognostic factor, Amino Acid Transport Systems, Science, Gene Expression, Diseases, L-Type Amino Acid Transporter, Article, Large Neutral Amino Acid-Transporter 1, Malignant lymphoma, immune system diseases, Cell Line, Tumor, hemic and lymphatic diseases, Neutral amino acid transport, medicine, Humans, Aged, Cell Proliferation, Cancer, Aged, 80 and over, Multidisciplinary, biology, Drug discovery, Membrane transport protein, Cell growth, Gene Expression Profiling, Lymphoma, Non-Hodgkin, Middle Aged, Prognosis, medicine.disease, Lymphoma, Non-Hodgkin's lymphoma, Gene Expression Regulation, Neoplastic, Oncology, Amino Acid Transport System L, biology.protein, Cancer research, Medicine, Female, Transcriptome |
| الوصف: | L-type neutral amino acid transporter 1 (LAT1) is a heterodimeric membrane transport protein involved in neutral amino acid transport. LAT1 is highly expressed in various malignant solid tumors and plays an essential role in cell proliferation. However, its role in malignant lymphoma remains unknown. Here, we evaluated LAT1 expression level in tissues from 138 patients with Non-Hodgkin lymphoma (NHL). Overexpression of LAT1 was confirmed in all types of NHL and we found that there is a significant correlation between the level of LAT1 expression and lymphoma grade. The LAT1 expression was higher in aggressive types of lymphomas when compared with static types of lymphomas, suggesting that active tumor proliferation requires nutrient uptake via LAT1. The expression level of LAT1 was inversely correlated with patients’ survival span. Furthermore, pharmacological inhibition of LAT1 by a specific inhibitor JPH203 inhibits lymphoma cell growth. In conclusion, our study demonstrated that LAT1 expression can be used as a prognostic marker for patients with NHL and targeting LAT1 by JPH203 can be a novel therapeutic modality for NHL. |
| اللغة: | English |
| تدمد: | 2045-2322 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e310310b3994aaafec3f03fff4b4794dTest https://doaj.org/article/254f7aaec22f4688a7954b03fd1e965bTest |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....e310310b3994aaafec3f03fff4b4794d |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20452322 |
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