Norovirus infection causes acute self-resolving diarrhea in wild-type neonatal mice
| العنوان: | Norovirus infection causes acute self-resolving diarrhea in wild-type neonatal mice |
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| المؤلفون: | Erin Kirsche, Nihal Altan-Bonnet, Laura B. Eurell, Sourish Ghosh, Christiane E. Wobus, Alexa N. Roth, Stephanie M. Karst, Carmen Mirabelli, Emily W. Helm, Jonathan C. Smith |
| المصدر: | Nature Communications Nature Communications, Vol 11, Iss 1, Pp 1-8 (2020) |
| بيانات النشر: | Nature Publishing Group UK, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | 0301 basic medicine, Diarrhea, Male, Systemic disease, Science, viruses, 030106 microbiology, ved/biology.organism_classification_rank.species, General Physics and Astronomy, Disease, medicine.disease_cause, General Biochemistry, Genetics and Molecular Biology, Article, 03 medical and health sciences, Mice, Dual role, fluids and secretions, Disease severity, medicine, Animals, Lymphocytes, lcsh:Science, Caliciviridae Infections, Mice, Inbred BALB C, Multidisciplinary, business.industry, ved/biology, Norovirus, Wild type, virus diseases, General Chemistry, medicine.disease, digestive system diseases, Disease Models, Animal, 030104 developmental biology, Animals, Newborn, Viral infection, Immunology, lcsh:Q, Female, medicine.symptom, business, Murine norovirus, Viral pathogenesis |
| الوصف: | Human noroviruses are the leading cause of severe childhood diarrhea worldwide, yet we know little about their pathogenic mechanisms. Murine noroviruses cause diarrhea in interferon-deficient adult mice but these hosts also develop systemic pathology and lethality, reducing confidence in the translatability of findings to human norovirus disease. Herein we report that a murine norovirus causes self-resolving diarrhea in the absence of systemic disease in wild-type neonatal mice, thus mirroring the key features of human norovirus disease and representing a norovirus small animal disease model in wild-type mice. Intriguingly, lymphocytes are critical for controlling acute norovirus replication while simultaneously contributing to disease severity, likely reflecting their dual role as targets of viral infection and key components of the host response. Here the authors show that a murine norovirus causes self-resolving diarrhea in the absence of systemic disease in wild-type neonatal mice and show that lymphocytes affect disease in a dual manner. The data suggests that neonatal mice are a promising model for further studies. |
| اللغة: | English |
| تدمد: | 2041-1723 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b97055a71095cd444e70ecff4d8983b8Test http://europepmc.org/articles/PMC7289885Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....b97055a71095cd444e70ecff4d8983b8 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20411723 |
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