دورية أكاديمية
Non-depleting anti-CD4 monoclonal antibody induces immune tolerance to ERT in a murine model of Pompe disease.
| العنوان: | Non-depleting anti-CD4 monoclonal antibody induces immune tolerance to ERT in a murine model of Pompe disease. |
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| المؤلفون: | Sun, Baodong, Banugaria, Suhrad G, Prater, Sean N, Patel, Trusha T, Fredrickson, Keri, Ringler, Douglas J, de Fougerolles, Antonin, Rosenberg, Amy S, Waldmann, Herman, Kishnani, Priya S |
| بيانات النشر: | Elsevier BV |
| سنة النشر: | 2014 |
| المجموعة: | Duke University Libraries: DukeSpace |
| مصطلحات موضوعية: | Anti-CD4 antibody, Antigen-specific immune tolerance, CRIM, cross-reacting immunologic material, ERT, enzyme replacement therapy, GAA, acid-α-glucosidase, IPD, infantile Pompe disease, ITI, immune tolerance induction, MTX, methotrexate, Pompe disease |
| جغرافية الموضوع: | United States |
| الوصف: | Approximately 35-40% of patients with classic infantile Pompe disease treated with enzyme replacement therapy (ERT) develop high, sustained antibody titers against the therapeutic enzyme alglucosidase alfa, which abrogates the treatment efficacy. Induction of antigen-specific immune tolerance would greatly enhance ERT for these patients. Here we show that a short-course treatment with non-depleting anti-CD4 monoclonal antibody successfully induced long-term ERT-specific immune tolerance in Pompe disease mice. Our data suggest an effective adjuvant therapy to ERT. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 2214-4269 |
| العلاقة: | Mol Genet Metab Rep; https://www.ncbi.nlm.nih.gov/pubmed/27896120Test; S2214-4269(14)00056-1; https://hdl.handle.net/10161/15084Test |
| الإتاحة: | https://hdl.handle.net/10161/15084Test https://www.ncbi.nlm.nih.gov/pubmed/27896120Test |
| رقم الانضمام: | edsbas.48ECA898 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 22144269 |
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