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المؤلفون: Mulder, Inge A., Khmelinskii, Artem, Dzyubachyk, Oleh, de Jong, Sebastiaan, Wermer, Marieke J. H., Hoehn, Mathias, Lelieveldt, Boudewijn P. F., van den Maagdenberg, Arn M. J. M.
مصطلحات موضوعية: ADC, Image registration, Transient middle cerebral artery occlusion, MRI, Ischemic stroke, C57BL/6J, DCX-Luc, Bruker, Image segmentation, mouse, DWI, Follow-up data, tMCAo, T2
الوصف: In this data report we make available to the community a highly variable longitudinal MRI mouse brain data set of ischemic lesion after transient middle cerebral artery occlusion (tMCAo). Together with the provided semi-automated and automated segmentations, these data can be used to further improve the method proposed by Mulder et al. (2017) and also to serve as a benchmark for comparison between different approaches to segment ischemic lesions in MRI mouse brain data. It can also be used to develop and validate algorithms that further classify the stroke area into core and penumbra. ; READ_ME CHANGES_LOG Cologne-Set-1 Cologne-Set-2 Leiden-Set-T2maps_Segmentations 3-5month_old_mice_PART_1 3-5month_old_mice_PART_2 3-5month_old_mice_PART_3 12-14month_old_mice 20-24month_old_mice LS_MHD_echoes_PART_1 LS_MHD_echoes_PART_2 Pulseprogram_files Template_Dataset_and_Labels
العلاقة: https://zenodo.org/communities/dryadTest; https://zenodo.org/record/4086450Test; https://doi.org/10.5061/dryad.1m528Test; oai:zenodo.org:4086450
الإتاحة: https://doi.org/10.5061/dryad.1m528Test
https://doi.org/10.3389/fninf.2017.00051Test
https://zenodo.org/record/4086450Test -
2دورية أكاديمية
المؤلفون: Hamming, Arend M, van der Toorn, Anette, Rudrapatna, U.S., Ma, Lisha, van Os, Hine J A, Ferrari, Michel D, van den Maagdenberg, Arn M J M, van Zwet, Erik, Poinsatte, Katherine, Stowe, Ann M, Dijkhuizen, Rick M, Wermer, Marieke J H
المساهمون: In Vivo NMR ISI, Circulatory Health, Brain
مصطلحات موضوعية: MRI, cortical spreading depression, experimental models, subarachnoid hemorrhage, valproic acid, Clinical Neurology, Cardiology and Cardiovascular Medicine, Advanced and Specialised Nursing
الوصف: BACKGROUND AND PURPOSE: Spreading depolarizations (SDs) may contribute to delayed cerebral ischemia after subarachnoid hemorrhage (SAH). We tested whether SD-inhibitor valproate reduces brain injury in an SAH rat model with and without experimental SD induction. METHODS: Rats were randomized in a 2×2 design and pretreated with valproate (200 mg/kg) or vehicle for 4 weeks. SAH was induced by endovascular puncture of the right internal carotid bifurcation. One day post-SAH, brain tissue damage was measured with T2-weighted magnetic resonance imaging, followed by cortical application of 1 mol/L KCl (to induce SDs) or NaCl (no SDs). Magnetic resonance imaging was repeated on day 3 followed by histology to confirm neuronal death. Neurological function was measured with an inclined slope test. RESULTS: In the groups with KCl application, lesion growth between days 1 and 3 was 57±73 mm3 in the valproate-treated versus 237±232 mm3 in the vehicle-treated group. In the groups without SD induction, lesion growth in the valproate- and vehicle-treated groups was 8±20 mm3 versus 27±52 mm3. On fitting a 2-way analysis of variance model, we found a significant interaction effect between treatment and KCl/NaCl application of 161 mm3 (P=0.04). Number and duration of SDs, mortality, and neurological function were not statistically significantly different between groups. Lesion growth on magnetic resonance imaging correlated to histological infarct volume (Spearman's rho =0.83; P=0.0004), with areas of lesion growth exhibiting reduced neuronal death compared with primary lesions. CONCLUSIONS: In our rat SAH model, valproate treatment significantly reduced brain lesion growth after KCl application. Future studies are needed to confirm that this protective effect is based on SD inhibition.
وصف الملف: application/pdf
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3دورية أكاديمية
المؤلفون: Mulder, Inge A., Khmelinskii, Artem, Dzyubachyk, Oleh, de Jong, Sebastiaan, Wermer, Marieke J. H., Hoehn, Mathias, Lelieveldt, Boudewijn P. F., van den Maagdenberg, Arn M. J. M.
مصطلحات موضوعية: Ischemic stroke, Transient middle cerebral artery occlusion, tMCAo, Mouse, C57BL/6J, DCX-Luc, Brain, MRI, Bruker, T2, DWI, ADC, Follow-up data, Image segmentation, Image registration
الوصف: In this data report we make available to the community a highly variable longitudinal MRI mouse brain data set of ischemic lesion after transient middle cerebral artery occlusion (tMCAo). Together with the provided semi-automated and automated segmentations, these data can be used to further improve the method proposed by Mulder et al. (2017) and also to serve as a benchmark for comparison between different approaches to segment ischemic lesions in MRI mouse brain data. It can also be used to develop and validate algorithms that further classify the stroke area into core and penumbra.
العلاقة: Mulder IA, Khmelinskii A, Dzyubachyk O, de Jong S, Wermer MJH, Hoehn M, Lelieveldt BPF, van den Maagdenberg AMJM (2017) MRI Mouse Brain Data of Ischemic Lesion after Transient Middle Cerebral Artery Occlusion. Frontiers in Neuroinformatics 11: 51.; http://hdl.handle.net/10255/dryad.150807Test
الإتاحة: https://doi.org/10.5061/dryad.1m528Test
https://doi.org/10.5061/dryad.1m528/1Test
https://doi.org/10.5061/dryad.1m528/3Test
https://doi.org/10.5061/dryad.1m528/4Test
https://doi.org/10.5061/dryad.1m528/5Test
https://doi.org/10.5061/dryad.1m528/6Test
https://doi.org/10.5061/dryad.1m528/7Test
https://doi.org/10.5061/dryad.1m528/8Test
https://doi.org/10.5061/dryad.1m528/9Test
https://doi.org/10.5061/dryad.1m528/10Test -
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المؤلفون: Mulder, Inge A., Khmelinskii, Artem, Dzyubachyk, Oleh, de Jong, Sebastiaan, Wermer, Marieke J. H., Hoehn, Mathias, Lelieveldt, Boudewijn P. F., van den Maagdenberg, Arn M.
مصطلحات موضوعية: Ischemic stroke, Transient middle cerebral artery occlusion, tMCAo, Mouse, C57BL/6J, DCX-Luc, Brain, MRI, Bruker, T2, DWI, ADC, Follow-up data, Image segmentation, Image registration
الإتاحة: https://doi.org/10.5061/dryad.1m528/1Test
https://doi.org/10.5061/dryad.1m528Test
http://hdl.handle.net/10255/dryad.151559Test -
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المؤلفون: Mulder, Inge A., Khmelinskii, Artem, Dzyubachyk, Oleh, de Jong, Sebastiaan, Wermer, Marieke J. H., Hoehn, Mathias, Lelieveldt, Boudewijn P. F., van den Maagdenberg, Arn M.
مصطلحات موضوعية: Ischemic stroke, Transient middle cerebral artery occlusion, tMCAo, Mouse, C57BL/6J, DCX-Luc, Brain, MRI, Bruker, T2, DWI, ADC, Follow-up data, Image segmentation, Image registration
الإتاحة: https://doi.org/10.5061/dryad.1m528/2Test
https://doi.org/10.5061/dryad.1m528Test
http://hdl.handle.net/10255/dryad.151564Test -
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المؤلفون: Mulder, Inge A., Khmelinskii, Artem, Dzyubachyk, Oleh, de Jong, Sebastiaan, Wermer, Marieke J. H., Hoehn, Mathias, Lelieveldt, Boudewijn P. F., van den Maagdenberg, Arn M.
مصطلحات موضوعية: Ischemic stroke, Transient middle cerebral artery occlusion, tMCAo, Mouse, C57BL/6J, DCX-Luc, Brain, MRI, Bruker, T2, DWI, ADC, Follow-up data, Image segmentation, Image registration
الإتاحة: https://doi.org/10.5061/dryad.1m528/13Test
https://doi.org/10.5061/dryad.1m528Test
http://hdl.handle.net/10255/dryad.151406Test -
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المؤلفون: Mulder, Inge A., Khmelinskii, Artem, Dzyubachyk, Oleh, de Jong, Sebastiaan, Wermer, Marieke J. H., Hoehn, Mathias, Lelieveldt, Boudewijn P. F., van den Maagdenberg, Arn M.
مصطلحات موضوعية: Ischemic stroke, Transient middle cerebral artery occlusion, tMCAo, Mouse, C57BL/6J, DCX-Luc, Brain, MRI, Bruker, T2, DWI, ADC, Follow-up data, Image segmentation, Image registration
الإتاحة: https://doi.org/10.5061/dryad.1m528/8Test
https://doi.org/10.5061/dryad.1m528Test
http://hdl.handle.net/10255/dryad.151399Test -
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المؤلفون: Mulder, Inge A., Khmelinskii, Artem, Dzyubachyk, Oleh, de Jong, Sebastiaan, Wermer, Marieke J. H., Hoehn, Mathias, Lelieveldt, Boudewijn P. F., van den Maagdenberg, Arn M.
مصطلحات موضوعية: Ischemic stroke, Transient middle cerebral artery occlusion, tMCAo, Mouse, C57BL/6J, DCX-Luc, Brain, MRI, Bruker, T2, DWI, ADC, Follow-up data, Image segmentation, Image registration
الإتاحة: https://doi.org/10.5061/dryad.1m528/12Test
https://doi.org/10.5061/dryad.1m528Test
http://hdl.handle.net/10255/dryad.151405Test -
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المؤلفون: Mulder, Inge A., Khmelinskii, Artem, Dzyubachyk, Oleh, de Jong, Sebastiaan, Wermer, Marieke J. H., Hoehn, Mathias, Lelieveldt, Boudewijn P. F., van den Maagdenberg, Arn M.
مصطلحات موضوعية: Ischemic stroke, Transient middle cerebral artery occlusion, tMCAo, Mouse, C57BL/6J, DCX-Luc, Brain, MRI, Bruker, T2, DWI, ADC, Follow-up data, Image segmentation, Image registration
الإتاحة: https://doi.org/10.5061/dryad.1m528/9Test
https://doi.org/10.5061/dryad.1m528Test
http://hdl.handle.net/10255/dryad.151401Test -
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المؤلفون: Mulder, Inge A., Khmelinskii, Artem, Dzyubachyk, Oleh, de Jong, Sebastiaan, Wermer, Marieke J. H., Hoehn, Mathias, Lelieveldt, Boudewijn P. F., van den Maagdenberg, Arn M.
مصطلحات موضوعية: Ischemic stroke, Transient middle cerebral artery occlusion, tMCAo, Mouse, C57BL/6J, DCX-Luc, Brain, MRI, Bruker, T2, DWI, ADC, Follow-up data, Image segmentation, Image registration
الإتاحة: https://doi.org/10.5061/dryad.1m528/4Test
https://doi.org/10.5061/dryad.1m528Test
http://hdl.handle.net/10255/dryad.151395Test
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