المؤلفون: Byg, Keld-Erik, Illés, Zsolt, Sejbæk, Tobias, Nguyen, Nina N. T. T., Möller, Sören, Lambertsen, Kate Lykke, Nielsen, Helle Hvilsted, Ellingsen, Torkell Juulsgaard

المصدر: Byg , K-E , Illés , Z , Sejbæk , T , Nguyen , N N T T , Möller , S , Lambertsen , K L , Nielsen , H H & Ellingsen , T J 2022 , ' A prospective, one-year follow-up study of patients newly diagnosed with neurosarcoidosis ' , Journal of Neuroimmunology , vol. 369 , 577913 . https://doi.org/10.1016/j.jneuroim.2022.577913Test

مصطلحات موضوعية: FAS, MRI, Neurosarcoidosis, SDMT, Treatment, mRS, Neuropsychological Tests, Central Nervous System Diseases/diagnostic imaging, Prospective Studies, Follow-Up Studies, Sarcoidosis, Humans

الوصف: Methods: Twenty patients with newly diagnosed neurosarcoidosis were examined for multiple outcomes in an observational cohort study with 12-month follow-up. Results: The patients' contrast-enhancing lesions on MRI scans reduced during treatment (p < 0.0001). The mean modified Rankin Score improved from 3.0 to 1.8 (p < 0.0001), and 75% of patients experienced clinically important improvement. Patients improved on the Symbol Digit Modalities Test (p < 0.0001) and on SF-36 Physical (p = 0.003) and Mental Component Summary scores (p = 0.03). Proportions of patients with substantial fatigue (75%) and high depression score (35%) were unchanged. Conclusions: 12-month immunosuppression improved several outcomes, and 75% of patients experienced clinically important improvement.

وصف الملف: application/pdf

العلاقة: https://portal.findresearcher.sdu.dk/da/publications/4dc7e180-23cc-4138-8a31-a6bd0f5a8cffTest

الإتاحة: https://doi.org/10.1016/j.jneuroim.2022.577913Test
https://portal.findresearcher.sdu.dk/da/publications/4dc7e180-23cc-4138-8a31-a6bd0f5a8cffTest
https://findresearcher.sdu.dk/ws/files/206092580/Open_Access_Version.pdfTest

المؤلفون: Byg, Keld Erik, Nielsen, Helle H., Sejbaek, Tobias, Madsen, Jonna Skov, Olsen, Dorte Aalund, Nguyen, Nina, Kindt, Astrid, Grauslund, Jakob, Illes, Zsolt, Ellingsen, Torkell

المصدر: Byg , K E , Nielsen , H H , Sejbaek , T , Madsen , J S , Olsen , D A , Nguyen , N , Kindt , A , Grauslund , J , Illes , Z & Ellingsen , T 2021 , ' Elevated neurofilament light chain in cerebrospinal fluid and plasma reflect inflammatory MRI activity in neurosarcoidosis ' , Brain Sciences , vol. 11 , no. 2 , 238 . https://doi.org/10.3390/brainsci11020238Test

مصطلحات موضوعية: Biomarker, Cerebrospinal fluid, MRI, Neurofilament light chain, Neurosarcoidosis

الوصف: Background: Damage to axonal cells releases neurofilament light chain (NFL) into the cerebrospinal fluid and plasma. The objective of this study was to investigate NFL as a potential biomarker of disease activity in neurosarcoidosis. MRIs were graded according to enhancing lesions at different central nervous system (CNS) sites. Results: In cerebrospinal fluid, levels of NFL were higher in neurosarcoidosis patients (n = 20) median 2304 pg/mL (interquartile range (IQR) 630-19,612) compared to 426 pg/mL (IQR 261-571) in extra-neurologic sarcoidosis patients (n = 20) and 336 pg/mL (IQR 194-402) in healthy controls (n = 11) (p = 0.0002). In plasma, levels of NFL were higher in neurosarcoidosis patients median 28.2 pg/mL (IQR 11.5-49.3) compared to 6.2 pg/mL (IQR 4.3-8.2) in extra-neurologic sarcoidosis patients and 7.1 pg/mL (IQR 6.2-9.0) in healthy controls (p = 0.0001). Levels in both cerebrospinal fluid and plasma were higher in neurosarcoidosis patients with moderate/severe enhancement than patients with mild enhancement on MRI (p = 0.009 and p = 0.005, respectively). To distinguish neurosarcoidosis patients from extra-neurologic patients and healthy controls, a cut-off level of 630 pg/mL in cerebrospinal fluid had 94% specificity and 79% sensitivity, while a cut-off level of 11.4 pg/mL in plasma had 97% specificity and 75% sensitivity. Conclusions: NFL levels in cerebrospinal fluid and plasma are significantly higher in neurosarcoidosis patients compared to extra-neurologic patients and healthy controls, and the levels correlate to the extent of inflammation on MRI.

وصف الملف: application/pdf

العلاقة: https://portal.findresearcher.sdu.dk/da/publications/81059bce-fd57-4947-8391-a005838f7a91Test

الإتاحة: https://doi.org/10.3390/brainsci11020238Test
https://portal.findresearcher.sdu.dk/da/publications/81059bce-fd57-4947-8391-a005838f7a91Test
https://findresearcher.sdu.dk/ws/files/179996395/brainsci_11_00238.pdfTest

المؤلفون: Byg, Keld-Erik, Nielsen, Helle H., Sejbaek, Tobias, Madsen, Jonna Skov, Olsen, Dorte Aalund, Nguyen, Nina, Kindt, Astrid, Grauslund, Jakob, Illes, Zsolt, Ellingsen, Torkell, Brahmajothi, Mulugu V.

المصدر: Brain Sciences (2076-3425); Feb2021, Vol. 11 Issue 2, p238, 1p

مصطلحات موضوعية: CEREBROSPINAL fluid, SARCOIDOSIS, CYTOPLASMIC filaments, CENTRAL nervous system, MAGNETIC resonance imaging

مستخلص: Background: Damage to axonal cells releases neurofilament light chain (NFL) into the cerebrospinal fluid and plasma. The objective of this study was to investigate NFL as a potential biomarker of disease activity in neurosarcoidosis. MRIs were graded according to enhancing lesions at different central nervous system (CNS) sites. Results: In cerebrospinal fluid, levels of NFL were higher in neurosarcoidosis patients (n = 20) median 2304 pg/mL (interquartile range (IQR) 630–19,612) compared to 426 pg/mL (IQR 261-571) in extra-neurologic sarcoidosis patients (n = 20) and 336 pg/mL (IQR 194–402) in healthy controls (n = 11) (p = 0.0002). In plasma, levels of NFL were higher in neurosarcoidosis patients median 28.2 pg/mL (IQR 11.5–49.3) compared to 6.2 pg/mL (IQR 4.3–8.2) in extra-neurologic sarcoidosis patients and 7.1 pg/mL (IQR 6.2–9.0) in healthy controls (p = 0.0001). Levels in both cerebrospinal fluid and plasma were higher in neurosarcoidosis patients with moderate/severe enhancement than patients with mild enhancement on MRI (p = 0.009 and p = 0.005, respectively). To distinguish neurosarcoidosis patients from extra-neurologic patients and healthy controls, a cut-off level of 630 pg/mL in cerebrospinal fluid had 94% specificity and 79% sensitivity, while a cut-off level of 11.4 pg/mL in plasma had 97% specificity and 75% sensitivity. Conclusions: NFL levels in cerebrospinal fluid and plasma are significantly higher in neurosarcoidosis patients compared to extra-neurologic patients and healthy controls, and the levels correlate to the extent of inflammation on MRI. [ABSTRACT FROM AUTHOR]

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