التفاصيل البيبلوغرافية
| العنوان: |
A prospective, one-year follow-up study of patients newly diagnosed with neurosarcoidosis. |
| المؤلفون: |
Byg, Keld-Erik1,2,3,4 (AUTHOR) keld-erik.byg@rsyd.dk, Illes, Zsolt2,3,5 (AUTHOR), Sejbaek, Tobias3,6,7 (AUTHOR), Nguyen, Nina8 (AUTHOR), Möller, Sören4,9 (AUTHOR), Lambertsen, Kate L.3,5 (AUTHOR), Nielsen, Helle H.1,2,3,5 (AUTHOR), Ellingsen, Torkell1,4 (AUTHOR) |
| المصدر: |
Journal of Neuroimmunology. Aug2022, Vol. 369, pN.PAG-N.PAG. 1p. |
| مصطلحات موضوعية: |
*SARCOIDOSIS, *PHYSICAL mobility, *COGNITIVE ability, *AZATHIOPRINE, *DIAGNOSIS, *METHOTREXATE |
| مستخلص: |
Twenty patients with newly diagnosed neurosarcoidosis were examined for multiple outcomes in an observational cohort study with 12-month follow-up. The patients' contrast-enhancing lesions on MRI scans reduced during treatment (p < 0.0001). The mean modified Rankin Score improved from 3.0 to 1.8 (p < 0.0001), and 75% of patients experienced clinically important improvement. Patients improved on the Symbol Digit Modalities Test (p < 0.0001) and on SF-36 Physical (p = 0.003) and Mental Component Summary scores (p = 0.03). Proportions of patients with substantial fatigue (75%) and high depression score (35%) were unchanged. 12-month immunosuppression improved several outcomes, and 75% of patients experienced clinically important improvement. • Glucocorticoid and methotrexate or azathioprine is effective in neurosarcoidosis. • MRI scans, physical functioning, cognitive function, and quality of life improved. • Depression and fatigue were unaffected by treatment. [ABSTRACT FROM AUTHOR] |
| قاعدة البيانات: |
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