التفاصيل البيبلوغرافية
| العنوان: |
In vitro modulation of lymphocyte responses to phytohaemagglutinin by plasma in mother and baby at the time of birth. |
| المؤلفون: |
Bjune, G., Duncan, Elizabeth, Barnetson, R. Stc., Melsom, R. |
| المصدر: |
Clinical & Experimental Immunology; Jun1978, Vol. 32 Issue 3, p517-522, 6p |
| مصطلحات موضوعية: |
HANSEN'S disease, INFANTS, MOTHERS, LYMPHOCYTES, BLOOD plasma, LABOR (Obstetrics) |
| مستخلص: |
Peripheral blood lymphocytes from nineteen healthy mothers, sixteen mothers with borderline tuberculoid leprosy and fourteen mothers with borderline or polar lepromatous leprosy, and their newborn babies, were stimulated in vitro with phytohaemagglutinin (PHA). The responses in medium supplemented by serum from a pool of healthy non-pregnant individuals were com- pared with responses in medium supplemented by plasma from the mothers or from their babies, to assay for the presence of non-specific effects on T-cell responses. It was found that plasma from the mothers at the time of labour profoundly suppressed their own lymphocyte responses to PHA. However, the lymphocyte responses of healthy mothers were not significantly suppressed when cultivated in the presence of plasma from the babies, indicating that the suppressive factor(s) of normal pregnancy did not pass the placental barrier. Plasma from mothers with leprosy had a greater inhibitory effect on their babies' lymphocytes than plasma from healthy mothers. This raises the possibility that plasma from leprosy patients contains suppressive factors other than those associated with pregnancy. Babies of lepromatous leprosy mothers, who might have been exposed to mycobacterial antigens in utero, had higher PHA responses than the other babies, possibly due to a compensatory reaction to early stresses in the immune system. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
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