التفاصيل البيبلوغرافية
| العنوان: |
Morphoea presenting histopathologically as mycosis fungoides: an illustrative series of four cases. |
| المؤلفون: |
Kazmi, Ahmed1,2 (AUTHOR), Feuerhake, Teo3 (AUTHOR), Zidan, Anoud3 (AUTHOR), Frewen, John4 (AUTHOR), Carmichael, Andrew5 (AUTHOR), Ross, Janet6 (AUTHOR), Orteu, Catherine H1 (AUTHOR), Calonje, Eduardo3 (AUTHOR) eduardo.calonje@gstt.nhs.uk |
| المصدر: |
Histopathology. Jun2024, p1. 6p. 2 Illustrations, 1 Chart. |
| مستخلص: |
Aims Methods and results Conclusion There have been exceptional reports of morphoea presenting with epidermal changes overlapping histopathologically with cutaneous T cell lymphoma of the mycosis fungoides type (MF). This phenomenon gives rise to an ambiguous clinicopathological scenario in which distinguishing these conditions may be challenging. The aim of this study is to characterise the clinical, histopathological and molecular findings of this phenomenon through a case series.Four patients with classical clinical presentation of morphoea but unusual histopathology displaying typical findings of morphoea, together with intra‐epidermal CD8 positive lymphocytes indistinguishable from MF, were identified. The clinical phenotypes of morphoea were varied, and they all presented early in the active phase of the disease. They all exhibited intra‐epidermal lymphocytes with tagging and cytological atypia. Pautrier‐like microabscesses were also seen. Using molecular analysis, two cases showed clonal TCR gene rearrangement. Follow‐up of all cases has been consistent with classical morphoea.Early morphoea can seldom present with atypical clonal intra‐epidermal lymphocytes indistinguishable from MF. The fact that these changes can occur in several different clinical subtypes of morphoea raises the possibility that this could be a pattern of inflammation in early disease more common than currently appreciated. [ABSTRACT FROM AUTHOR] |
| قاعدة البيانات: |
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