دورية أكاديمية
Exploring the role of novel medical therapies for aggressive pituitary tumors: A review of the literature—“are we there yet?”
| العنوان: | Exploring the role of novel medical therapies for aggressive pituitary tumors: A review of the literature—“are we there yet?” |
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| المؤلفون: | Lamb, LS, Sim, HW, McCormack, AI |
| المصدر: | urn:ISSN:2072-6694 ; Cancers, 12, 2, 308 |
| بيانات النشر: | MDPI |
| سنة النشر: | 2020 |
| المجموعة: | UNSW Sydney (The University of New South Wales): UNSWorks |
| مصطلحات موضوعية: | Brain Cancer, Cancer, Brain Disorders, Rare Diseases, 3 Good Health and Well Being, aggressive pituitary tumors, immunotherapy, molecular profiling, pituitary carcinoma, targeted therapy, anzsrc-for: 1112 Oncology and Carcinogenesis |
| الوصف: | Aggressive pituitary tumors account for up to 10% of pituitary tumors and are characterized by resistance to medical treatment and multiple recurrences despite standard therapies, including surgery, radiotherapy, and chemotherapy. They are associated with increased morbidity and mortality, particularly pituitary carcinomas, which have mortality rates of up to 66% at 1 year after diagnosis. Novel targeted therapies under investigation include mammalian target of rapamycin (mTOR), tyrosine kinase, and vascular endothelial growth factor (VEGF) inhibitors. More recently, immune checkpoint inhibitors have been proposed as a potential treatment option for pituitary tumors. An increased understanding of the molecular pathogenesis of aggressive pituitary tumors is required to identify potential biomarkers and therapeutic targets. This review discusses novel approaches to the management of aggressive pituitary tumors and the role of molecular profiling. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | unknown |
| العلاقة: | http://hdl.handle.net/1959.4/unsworks_74518Test; https://unsworks.unsw.edu.au/bitstreams/7468f8d7-9d1f-4068-8c61-3e737ff59866/downloadTest; https://doi.org/10.3390/cancers12020308Test |
| DOI: | 10.3390/cancers12020308 |
| الإتاحة: | https://doi.org/10.3390/cancers12020308Test http://hdl.handle.net/1959.4/unsworks_74518Test https://unsworks.unsw.edu.au/bitstreams/7468f8d7-9d1f-4068-8c61-3e737ff59866/downloadTest |
| حقوق: | open access ; https://purl.org/coar/access_right/c_abf2Test ; CC BY ; https://creativecommons.org/licenses/by/4.0Test/ ; free_to_read |
| رقم الانضمام: | edsbas.EAC15FC3 |
| قاعدة البيانات: | BASE |
| DOI: | 10.3390/cancers12020308 |
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