المؤلفون: Keun Ah Ryu, Erik C. Hett, Noah B. Bissonnette, M Jared Willis, Rob C. Oslund, Olugbeminiyi O. Fadeyi, Tamara Reyes-Robles, Lee R. Roberts, Sharon Wilhelm, Jake H. Tomlinson, Kelly A. Crotty, Daria J. Hazuda

المصدر: Chembiochem

مصطلحات موضوعية: Light, Chemical biology, Biotin, Tyramine, Nanotechnology, Visible light photocatalytic, 010402 general chemistry, 01 natural sciences, Biochemistry, Catalysis, Photobioreactors, Cell Line, Tumor, Humans, Molecular Biology, multiplex capabilities, photochemistry, Molecular Structure, Full Paper, 010405 organic chemistry, Chemistry, Organic Chemistry, Equipment Design, Full Papers, Photochemical Processes, live-cell labeling, photoredox, proteins, 0104 chemical sciences, Photocatalysis, Molecular Medicine, photoreactors, Visible spectrum

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12eb5f076f33f94fbbe02bfeb228bc34Test
https://doi.org/10.1002/cbic.202000392Test

المؤلفون: Jian Liu, Brian Squadroni, Bonnie J. Howell, Paul Zuck, Wensheng Yu, Daria J. Hazuda, Joe Kozlowski, Jeanine E. Ballard, Ryan C. Vargo, Richard J. O. Barnard, Jason Cassaday, Guoxin Wu, Munjal Patel, William Newhard

المصدر: SLAS discovery : advancing life sciences RD. 26(5)

مصطلحات موضوعية: Gene Expression Regulation, Viral, Cell, Cell Culture Techniques, HIV Infections, Pharmacology, Virus Replication, Biochemistry, Jurkat cells, Analytical Chemistry, 03 medical and health sciences, Jurkat Cells, Pharmacokinetics, In vivo, medicine, Humans, Latency (engineering), Cells, Cultured, 030304 developmental biology, Automation, Laboratory, 0303 health sciences, 030306 microbiology, Chemistry, HIV, Models, Theoretical, In vitro, Virus Latency, Histone Deacetylase Inhibitors, medicine.anatomical_structure, Pharmacodynamics, Molecular Medicine, Histone deacetylase, Biotechnology

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b6796f1335c27c8423ccf8769b32223Test
https://pubmed.ncbi.nlm.nih.gov/33427012Test

المؤلفون: Elizabeth Thoryk, David S. Thiriot, Sayda Elbashir, Jeffrey G. Smith, Nicole L Sullivan, Christine A. Shaw, Morgan A. Monslow, Kalpit A. Vora, Nithya Thambi, Daria J. Hazuda, Cook James C, Patrick L. Ahl, Elise Miller, Michael P. Citron, Scott Cosmi

المصدر: Vaccine. 38(36)

مصطلحات موضوعية: Herpesvirus 3, Human, viruses, medicine.medical_treatment, 030231 tropical medicine, medicine.disease_cause, Antibodies, Viral, Vaccines, Attenuated, Herpes Zoster, Virus, 03 medical and health sciences, 0302 clinical medicine, Antigen, Viral Envelope Proteins, Medicine, Animals, Herpes Zoster Vaccine, 030212 general & internal medicine, RNA, Messenger, Attenuated vaccine, integumentary system, General Veterinary, General Immunology and Microbiology, business.industry, Immunogenicity, Public Health, Environmental and Occupational Health, Varicella zoster virus, virus diseases, biochemical phenomena, metabolism, and nutrition, Vaccine efficacy, Virology, Vaccination, Infectious Diseases, Vaccines, Subunit, Molecular Medicine, business, Adjuvant

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a1bedcc5881ed1417625c9c9757c852Test
https://pubmed.ncbi.nlm.nih.gov/32703745Test

المؤلفون: Jay A. Grobler, Abbas Walji, Paul J. Coleman, Min Xu, Timothy J. Hartingh, Natasa Pajkovic, John T. Sisko, David A. Powell, John M. Sanders, Michael D. Miller, Mark Embrey, Rada Vanessa L, Keith P. Moore, Daniel J. Klein, Nguyen Natalie, Izzat T. Raheem, Dubost David C, Guillaume Barbe, Louis-Charles Campeau, Daria J. Hazuda, John S. Wai, Thomas G. Steele, John D. Schreier, Jamie M. McCabe Dunn

المصدر: Bioorganic & Medicinal Chemistry Letters. 27:2038-2046

مصطلحات موضوعية: 0301 basic medicine, Pyridones, Clinical Biochemistry, Human immunodeficiency virus (HIV), Pharmaceutical Science, Integrase inhibitor, HIV Infections, HIV Integrase, Pharmacology, medicine.disease_cause, 01 natural sciences, Biochemistry, Strand transfer, 03 medical and health sciences, chemistry.chemical_compound, Dogs, Drug Discovery, medicine, Animals, Humans, Structure–activity relationship, HIV Integrase Inhibitors, Molecular Biology, biology, Organic Chemistry, Raltegravir, 0104 chemical sciences, Integrase, Molecular Docking Simulation, 010404 medicinal & biomolecular chemistry, 030104 developmental biology, chemistry, HIV-1, Aminal, biology.protein, Molecular Medicine, Lead compound, medicine.drug

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3afda9a20f9b604f336f17e0d16627bTest
https://doi.org/10.1016Test/j.bmcl.2017.02.039

المؤلفون: Marta De Zotti, Bernard Kaptein, Peter J. Felock, Daria J. Hazuda, Sheo B. Singh, Quirinus B. Broxterman, Fernando Formaggio, Hans Brückner, Claudio Toniolo

المصدر: ChemBioChem. 10:87-90

مصطلحات موضوعية: Magnetic Resonance Spectroscopy, Stereochemistry, Molecular Sequence Data, Stereoisomerism, HIV Integrase, conformation in solution, Biochemistry, NMR spectroscopy, Amino Acid Sequence, HIV Integrase Inhibitors, Molecular Biology, Peptide sequence, Chromatography, High Pressure Liquid, Biological Products, Chemistry, Organic Chemistry, Peptide inhibitor, Absolute configuration, Total synthesis, peptaibiotics, helical peptides, Hiv 1 integrase, Molecular Medicine, Oligopeptides

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a63ad1ba963b79fcdaa6fb6df1a41f10Test
https://doi.org/10.1002/cbic.200800443Test

المؤلفون: Janet Lineberger, Matthew G. Stanton, Amy S. Espeseth, Beth Pietrak, Min Xu, Katherine Tugusheva, Harold G. Selnick, Dennis Colussi, Guy R. Seabrook, John Swestock, Jason Kahana, Ming-Chih Crouthamel, Viswanath Devanarayan, Keala X. Tyler, Guoxin Wu, Daria J. Hazuda, Shaun R. Stauffer, Joan D. Ellis, Marie A. Holahan, Joseph P. Vacca, Philippe G. Nantermet, Melissa A. Steinbeiser, Georgia B. McGaughey, Eric A. Price, Jerome Hochman, Hemaka A. Rajapakse, Sethu Sankaranarayanan, Adam J. Simon, Samuel L. Graham, Keith P. Moore, M. Katharine Holloway, Ming-Tain Lai, Lixia Jin, Adam Gates, Xiao-Ping Shi, Jacky Wong, Jacquelynn J. Cook, Allison R. Gregro

المصدر: Journal of Pharmacology and Experimental Therapeutics. 328:131-140

مصطلحات موضوعية: medicine.medical_specialty, Membrane permeability, Mice, Transgenic, Pharmacology, Transfection, Cisterna magna, Amyloid beta-Protein Precursor, Mice, Cerebrospinal fluid, Pharmacokinetics, Oral administration, In vivo, Internal medicine, medicine, Amyloid precursor protein, Animals, Aspartic Acid Endopeptidases, Humans, ATP Binding Cassette Transporter, Subfamily B, Member 1, Enzyme Inhibitors, Infusions, Intravenous, biology, Macaca mulatta, Endocrinology, biology.protein, Molecular Medicine, Amyloid Precursor Protein Secretases, Amyloid precursor protein secretase

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01219a959e3def2dc15d6af0a2e96474Test
https://doi.org/10.1124/jpet.108.143628Test

المؤلفون: Kenneth E. Rittle, Dorothy Levorse, James C. Barrow, Eric A. Price, Katherine Tugusheva, Ming Tain Lai, Abigail Wolfe, Dennis Colussi, Paul Zuck, Shaun R. Stauffer, Adam J. Simon, Samuel L. Graham, M. Katharine Holloway, Zhi Qiang Yang, Georgia B. McGaughey, Amy S. Espeseth, Phung L. Ngo, Beth Pietrak, Min Xu, Qian Huang, Joseph P. Vacca, Sethu Sankaranarayanan, Daria J. Hazuda, Sanjeev Munshi, Harold G. Selnick

المصدر: Journal of Medicinal Chemistry. 51:6259-6262

مصطلحات موضوعية: Models, Molecular, chemistry.chemical_classification, Molecular Structure, biology, Molecular model, Bicyclic molecule, Chemistry, Stereochemistry, Drug Evaluation, Preclinical, Hydrogen Bonding, Crystal structure, Crystallography, X-Ray, Imidazolidines, Chemical synthesis, Cocrystal, Structure-Activity Relationship, Enzyme, Piperidines, Enzyme inhibitor, Drug Discovery, biology.protein, Amyloid precursor protein, Molecular Medicine, Amyloid Precursor Protein Secretases, Enzyme Inhibitors

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09b39bb3a2bd901885cd23cf513dd12eTest
https://doi.org/10.1021/jm800914nTest

المؤلفون: Joseph P. Vacca, Linghang Zhuang, Lori J. Gabryelski, Terry A. Lyle, William A. Schleif, Peter J. Felock, Boyoung Kim, Lixia Jin, I.-W. Chen, Donnette D. Staas, Chris Culberson, Steven D. Young, Daria J. Hazuda, Thorsten E. Fisher, John S. Wai, Peter D. Williams, Mark Embrey, Rama Mallai, Joan D. Ellis

المصدر: Bioorganic & Medicinal Chemistry Letters. 17:5595-5599

مصطلحات موضوعية: Models, Molecular, Clinical Biochemistry, Pharmaceutical Science, Integrase inhibitor, Virus Replication, Biochemistry, Cell Line, Structure-Activity Relationship, In vivo, Drug Discovery, Animals, Humans, HIV Integrase Inhibitors, Molecular Biology, chemistry.chemical_classification, Molecular Structure, biology, Organic Chemistry, HIV, Benzene, biology.organism_classification, In vitro, Rats, Integrase, Enzyme, chemistry, Viral replication, Enzyme inhibitor, Pyrazines, Lentivirus, Microsomes, Liver, biology.protein, Molecular Medicine

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c7dd8e0e282073e0fa1b3f0f4f284aeTest
https://doi.org/10.1016Test/j.bmcl.2007.07.092

المؤلفون: Gregory Moyer, Linghang Zhuang, Lori J. Gabryelski, Marc V. Witmer, Lixia Jin, Jiunn H. Lin, William A. Schleif, Yvonne M. Leonard, Peter J. Felock, Mark Embrey, Nancy N. Tsou, Kara A. Stillmock, Joseph P. Vacca, Debbie S. Perlow, Steven D. Young, Bradley K. Wong, Carl F. Homnick, Timothy W. Funk, John S. Wai, Joan D. Ellis, Daria J. Hazuda, I.-W. Chen

المصدر: Bioorganic & Medicinal Chemistry Letters. 15:4550-4554

مصطلحات موضوعية: Stereochemistry, Clinical Biochemistry, Biological Availability, Pharmaceutical Science, Integrase inhibitor, Crystallography, X-Ray, Virus Replication, Biochemistry, chemistry.chemical_compound, Benzyl Compounds, Drug Discovery, Animals, HIV Integrase Inhibitors, Naphthyridines, Uracil, Molecular Biology, chemistry.chemical_classification, biology, Chemistry, Organic Chemistry, Dihydrouracil, Nucleotidyltransferase, In vitro, Rats, Integrase, Enzyme, Viral replication, Enzyme inhibitor, HIV-1, biology.protein, Molecular Medicine

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee10371fe67e0664a66800a9d205a2a7Test
https://doi.org/10.1016Test/j.bmcl.2005.06.105

المؤلفون: Janet Lineberger, Emilio A. Emini, Julie A. DeMartino, Dooseop Kim, Michael W. Miller, Richard J. Budhu, Karen Henry, Renee Hrin, Gwen Carver, Lorraine Malkowitz, Anthony Carella, William A. Schleif, Malcolm MacCoss, Sandra L. Gould, Joseph Kessler, Daria J. Hazuda, Sander G. Mills, Christopher L. Lynch, Liping Wang, Jeffrey J. Hale, Martin S. Springer

المصدر: Bioorganic & Medicinal Chemistry Letters. 15:2129-2134

مصطلحات موضوعية: Imidazopyridine, Pyrrolidines, Receptors, CCR5, Anti-HIV Agents, Stereochemistry, Clinical Biochemistry, Administration, Oral, Pharmaceutical Science, CCR5 receptor antagonist, Biochemistry, Pyrrolidine, chemistry.chemical_compound, Heterocyclic Compounds, Drug Discovery, Side chain, Animals, Humans, Receptor, Molecular Biology, Chemistry, Organic Chemistry, Antagonist, virus diseases, Biological activity, Rats, CCR5 Receptor Antagonists, Molecular Medicine, Piperidine, HeLa Cells

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd7d85c01fc28b7691f984018117a231Test
https://doi.org/10.1016Test/j.bmcl.2005.02.030