رسالة جامعية
Exploración de modificaciones estructurales de un antígeno de la proteína MSP1 de Plasmodium spp y su influencia en su propiedad de reconocimiento molecular por sueros murinos y humanos, de personas de áreas postconflicto en Colombia ; Exploration of structural modifications of an MSP1 protein antigen from Plasmodium spp and their influence on its molecular recognition property by murine and human sera from people from post-conflict areas in Colombia
| العنوان: | Exploración de modificaciones estructurales de un antígeno de la proteína MSP1 de Plasmodium spp y su influencia en su propiedad de reconocimiento molecular por sueros murinos y humanos, de personas de áreas postconflicto en Colombia ; Exploration of structural modifications of an MSP1 protein antigen from Plasmodium spp and their influence on its molecular recognition property by murine and human sera from people from post-conflict areas in Colombia |
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| المؤلفون: | Melo Velanida, Fredy Leonardo |
| المساهمون: | Lozano Moreno, José Manuel, Mimetismo Molecular de Los Agentes Infecciosos |
| بيانات النشر: | Universidad Nacional de Colombia Bogotá - Ciencias - Maestría en Ciencias - Farmacología Facultad de Ciencias Bogotá, Colombia Universidad Nacional de Colombia - Sede Bogotá |
| سنة النشر: | 2023 |
| مصطلحات موضوعية: | 610 - Medicina y salud::615 - Farmacología y terapéutica, 610 - Medicina y salud::616 - Enfermedades, Simulación del acoplamiento molecular, Plasmodium falciparum, Plasmodium berghei, Antígenos de protozoos, Plasmodium yoelii, Malaria-Tratamiento farmacológico, Técnicas Inmunológicas, Molecular docking simulation, Antigens, protozoan, Immunologic techniques, Proteína MSP1, Plasmodium falciparum 3D7, Plasmodium berghei ANKA, Plasmodium yoelii 17XL, Malaria, Modificación amida reducida, Acoplamiento molecular, MSP1 protein, Reduced amide modification, Molecular docking |
| جغرافية الموضوع: | Colombia |
| الوصف: | ilustraciones a color, diagramas, fotografías ; Estudios realizados en el marco de investigación del grupo de mimetismo molecular de los agentes infecciosos, evaluaron la reactividad de sueros de áreas endémicas de Colombia (san juan de nepomuceno - bolívar, tierralta - córdoba, nuquí - chocó y tumaco - nariño) (SIVIGILA, instituto nacional de salud, 2018), frente a lisados de dos cepas de referencia, 3D7 y FCB2 de Plasmodium falciparum, donde se identificaron bandas de reconocimiento de la proteína MSP1 con movilidades relativas de 195, 83, 42 y 38 kDa, que permitieron identificar la reactividad de sueros frente a la proteína precursora MSP1 y sus fragmentos de procesamiento, lo que valida la importancia de este antígeno de superficie respecto a su papel inmunológico, perfilándola como una proteína blanco en la implementación de modificaciones tipo amida reducida, que promuevan y evidencien una protección efectiva de individuos expuestos a la infección natural. (Texto tomado de la fuente) ; Studies carried out within the research framework of the molecular mimicry of infectious agents group, evaluated the reactivity of sera from endemic areas of Colombia (San Juan de Nepomuceno - Bolívar, Tierralta - Córdoba, Nuquí - Chocó and Tumaco - Nariño) (SIVIGILA, national institute of health, 2018), compared to lysates of two reference strains, 3D7 and FCB2 of Plasmodium falciparum, where recognition bands of the MSP1 protein were identified with relative mobilities of 195, 83, 42 and 38 kDa, which allowed the identification the reactivity of sera against the MSP1 precursor protein and its processing fragments, which validates the importance of this surface antigen with respect to its immunological role, profiling it as a target protein in the implementation of reduced amide type modifications, which promote and demonstrate effective protection of individuals exposed to natural infection. ; La Convocatoria para el Apoyo a Proyectos de Investigación y Creación Artística de la Sede Bogotá de la Universidad Nacional de ... |
| نوع الوثيقة: | master thesis |
| وصف الملف: | [100] páginas; application/pdf |
| اللغة: | Spanish; Castilian |
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| الإتاحة: | https://doi.org/10.1046/j.1365-3156.1999.00406Test https://doi.org/10.1371/journal.ppat.1007599Test https://doi.org/10.4269/ajtmh.1994.51.593Test https://doi.org/10.7705/biomedica.v37i2.3263Test https://doi.org/10.2174/1874220301603010269Test https://doi.org/10.1093/nar/gkn814Test https://doi.org/10.1093/nar/gkg081Test https://doi.org/10.1080/00034989859366Test https://doi.org/10.1186/1475-2875-13-144Test https://doi.org/10.1073/pnas.83.4.1065Test |
| حقوق: | Atribución-NoComercial-CompartirIgual 4.0 Internacional ; http://creativecommons.org/licenses/by-nc-sa/4.0Test/ ; info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.14E88B5F |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |