المؤلفون: Xiaoqiao Shi, Junwei Li, Zhiwen Liu

المصدر: Molecular Medicine Reports

مصطلحات موضوعية: 0301 basic medicine, Cancer Research, Cell Survival, Cell, Anti-Inflammatory Agents, cardiomyocytes, CHOP, Biochemistry, Models, Biological, Flow cytometry, Cell Line, Andrology, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Lactate dehydrogenase, Genetics, medicine, Animals, Myocytes, Cardiac, Viability assay, C/EBP-homologous protein, Molecular Biology, medicine.diagnostic_test, L-Lactate Dehydrogenase, dexmedetomidine, Articles, hypoxia/reoxygenation injury, Cell cycle, Endoplasmic Reticulum Stress, Cell Hypoxia, 030104 developmental biology, medicine.anatomical_structure, cell proliferation, Oncology, chemistry, Gene Expression Regulation, Apoptosis, 030220 oncology & carcinogenesis, Molecular Medicine, Signal transduction, Transcription Factor CHOP, Signal Transduction

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e94f6991bbbcd82934f1a6edd82d3c7Test
http://europepmc.org/articles/PMC7453597Test

المؤلفون: Wing-Kee Lee, Michelle Maaß, Amy Quach, Nataliya Poscic, Holly Prangley, Erin-Claire Pallott, Jiyoon L. Kim, Jason S. Pierce, Besim Ogretmen, Anthony H. Futerman, Frank Thévenod

المصدر: The Journal of Biological Chemistry

مصطلحات موضوعية: TG, thapsigargin, Male, cancer drug resistance, FASN, fatty acid synthase, Biochemistry, ERAD, ER-associated degradation, UPR, unfolded protein response, MDR, multidrug resistance, Tandem Mass Spectrometry, Sphingosine N-Acyltransferase, Tumor Microenvironment, HERPUD1, homocysteine-inducible ER protein with ubiquitin-like domain 1, GRP78, glucose-regulated protein 78 kDa, unfolded protein response, Endoplasmic Reticulum-Associated Degradation, Kidney Neoplasms, XBP1, X-box binding protein 1, lipids (amino acids, peptides, and proteins), Female, ABC transporter, ATP6α, activating transcription factor 6α, Research Article, ATP Binding Cassette Transporter, Subfamily B, PDIA4, protein disulfide isomerase family A member 4, P-glycoprotein, CHOP, C/EBP homologous protein, Ceramides, ACACA, acetyl-CoA carboxylase alpha, ER, endoplasmic reticulum, VLC, very long chain, LCC, long-chain ceramide, HPCT, human proximal convoluted tubule, Humans, RNA, Messenger, TUN, tunicamycin, Molecular Biology, Sphingolipids, SM, sphingomyelin, UCSC, University of California, Santa Cruz, SREBP, sterol-regulatory element binding protein, LD, lipid domain, Tumor Suppressor Proteins, Membrane Proteins, Cell Biology, DOX, doxorubicin, Doxorubicin, Drug Resistance, Neoplasm, Mff, mitochondrial fission factor, CerS, ceramide synthase, HMGCL, 3-hydroxymethyl-3-methylglutaryl-CoA lyase, TM, transmembrane

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d1819640a96f5d4d5386b5634e205d7Test
http://europepmc.org/articles/PMC8804196Test

المؤلفون: Rohit Sharma, Jarin T. Snyder, Laura C. Alonso

المصدر: Molecular Metabolism
Molecular Metabolism, Vol 27, Iss, Pp S69-S80 (2019)

مصطلحات موضوعية: 0301 basic medicine, lcsh:Internal medicine, Programmed cell death, Cell type, Bcl-2, B-cell lymphoma 2, Cell Survival, Activating transcription factor 6, Replication, 030209 endocrinology & metabolism, Apoptosis, Cell Count, Review, Jnk, c-Jun N-terminal kinase, mTor, mammalian target of rapamycin, Cell fate determination, Biology, medicine.disease_cause, S1P, site 1 protease, ER, endoplasmic reticulum, 03 medical and health sciences, 0302 clinical medicine, Atf6α, Activating transcription factor alpha, medicine, Animals, Humans, cFos, human homolog of Finkel–Biskis–Jinkins murine osteogenic sarcoma virus oncogene, ERAD, ER associated degradation, Pancreatic beta cell, lcsh:RC31-1245, Molecular Biology, Cell Proliferation, S2P, site 2 protease, Cell Death, Rheb, Ras homolog, mTor binding, Chop, C/EBP homologous protein, Cell Biology, Cell cycle, Vegf, Vascular endothelial growth factor, 030104 developmental biology, Secretory protein, Unfolded protein response, Beta cell, Carcinogenesis, Runx2, Runt-related transcription factor 2, Neuroscience

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01aa24f685d0adce07b3a208b6f3cbf5Test
http://europepmc.org/articles/PMC6768497Test

المؤلفون: David Hood, Jonathan Memme, Ashley Oliveira

المصدر: The Journal of Biological Chemistry

مصطلحات موضوعية: p53, muscle atrophy, mitochondrial biogenesis, ATF4, activating transcription factor 4, log2FC, log2 fold change, Biochemistry, mKO, muscle-specific KO, Mice, transcriptomics, 0302 clinical medicine, GSEA, gene set enrichment analysis, PINK1, phosphatase and tensin homolog–induced kinase 1, ClpP, caseinolytic mitochondrial matrix peptidase proteolytic subunit, SirT3, sirtuin 3, TFEB, transcription factor EB, UPRmt, mitochondrial unfolded protein response, PGC-1α, peroxisome proliferator–activated receptor gamma coactivator 1 alpha, 0303 health sciences, mitochondrial quality control, EDL, extensor digitorum longus, Mitophagy, unfolded protein response, LC3, microtubule-associated proteins 1a/1b light chain 3, CtsD, cathepsin D, Denervation, MQC, mitochondrial quality control, mitochondria, Muscular Atrophy, LonP, lon protease homolog, mitochondrial, CON, control, COX, cytochrome c oxidase, SDH, succinate dehydrogenase, lysosome, HSP, heat shock protein, Research Article, DEN, denervated, REVIGO, reduce and visualize Gene Ontology, CHOP, C/EBP homologous protein, 03 medical and health sciences, cDNA, complementary DNA, ROS, reactive oxygen species, GO, Gene Ontology, Animals, skeletal muscle, Muscle, Skeletal, Molecular Biology, 030304 developmental biology, Atg, autophagy-related protein, TA, tibialis anterior, ATF5, activating transcription factor 5, Prkn, Parkin, TFE3, transcription factor E3, Cell Biology, p62, sequestosome-1, Mitochondria, Muscle, mtDNA, mitochondrial DNA, Tumor Suppressor Protein p53, qPCR, quantitative PCR, 030217 neurology & neurosurgery

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0eb3a97e49a86a03392f94c39be1c648Test
https://pubmed.ncbi.nlm.nih.gov/34958797Test

المؤلفون: Karin Musier-Forsyth, Ronald C. Wek, Sheree A. Wek, Marina Bakhtina, William A. Cantara, Nathan T. Kudlapur, Danni Jin

المصدر: The Journal of Biological Chemistry

مصطلحات موضوعية: Male, multisynthetase complex, ATF4, activating transcription factor 4, aminoacyl-tRNA synthetases, medicine.disease_cause, Biochemistry, chemistry.chemical_compound, RNA, Transfer, enzyme kinetics, AIMP, ARS-complex interacting multifunctional protein, PERK, PKR-like endoplasmic reticulum kinase, glutamyl-prolyl-tRNA synthetase, Protein biosynthesis, Amino Acids, CD, circular dichroism, Amino acid activation, chemistry.chemical_classification, Mutation, FA, fluorescence anisotropy, Editors' Pick, integrated stress response, ARS, aminoacyl-tRNA synthetase, Amino acid, Cell biology, GAIT, gamma interferon-activated inhibition of translation, Bone Diseases, compound-heterozygous mutations, Research Article, SEC, size-exclusion chromatography, PRS, prolyl-tRNA synthetase, Mutation, Missense, tRNA charging, Amino Acyl-tRNA Synthetases, Editors' Pick Highlight, MSC, multisynthetase complex, Stress, Physiological, genetic disease, aaRSs, aminoacyl-tRNA synthetases, GST, glutathione-S-transferase, Diabetes Mellitus, medicine, Integrated stress response, Humans, EPRS, glutamyl-prolyl-tRNA synthetase, Molecular Biology, CHOP, C/EBP-homologous protein, ISR, integrated stress response, MALS, multiangle laser light scattering, GCN2, general control nonderepressible 2, Aminoacyl tRNA synthetase, Genetic Diseases, Inborn, Cell Biology, stress response, EPRS, TRNA binding, WT, wild-type, compound heterozygous mutations, Glutamate-tRNA Ligase, HEK293 Cells, Amino Acid Substitution, chemistry, DTT, dithiothreitol, Protein Biosynthesis, Aminoacyl-tRNA synthetase, endoplasmic reticulum stress (ER stress), ERS, glutamyl-tRNA synthetase

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ce97fb563092e3b298c457fe5bda992Test
http://europepmc.org/articles/PMC8511952Test

المؤلفون: Arun Nandwani, Malabika Datta, Shweta Tiwary, Rukshar Khan

المصدر: The Journal of Biological Chemistry

مصطلحات موضوعية: Glucose-regulated protein, OGTT, oral glucose tolerance test, MFN2, Palmitic Acid, Apoptosis, Mitochondrion, Endoplasmic Reticulum, Biochemistry, Mice, Insulin-Secreting Cells, MFN1, GRP75, glucose regulated protein 75, MFN1, mitofusin1, MFN2, mitofusin2, biology, Chemistry, BiP, binding immunoglobulin protein, Cell biology, Mitochondria, FACL4, fatty acid-CoA ligase type4, medicine.anatomical_structure, VDAC, voltage-dependent anion channel, Research Article, Pancreatic Insulinoma, GRP75, ER–mitochondria contact, calcium apoptosis, CHOP, C/EBP homologous protein, Cell Line, Mitochondrial Proteins, ER, endoplasmic reticulum, TEM, transmission electronic microscopy, IP3R, inositol 1,4,5 trisphosphate receptor, Cell Line, Tumor, medicine, Animals, HSP70 Heat-Shock Proteins, Molecular Biology, PACS2, phosphofurin acidic cluster sorting protein 2, ITT, insulin tolerance test, Ion Transport, PLA, proximity ligation assay, Pancreatic islets, Endoplasmic reticulum, Cell Biology, Glucose Tolerance Test, Rats, Hyperglycemia, Membrane biogenesis, biology.protein, Calcium, palmitate, BSA, bovine serum albumin, MAM, mitochondria-associated membrane, Insulin Resistance

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d715e36f7f811e5af64fce26110f56edTest
https://pubmed.ncbi.nlm.nih.gov/34756890Test

المؤلفون: Zhen Du, Yavuz Kulaberoglu, Laura S. Itzhaki, Christopher M. Dobson, Ewan St. John Smith, Sampurna Chakrabarti, Janet R. Kumita

المساهمون: Smith, Ewan [0000-0002-2699-1979], Itzhaki, Laura [0000-0001-6504-2576], Kumita, Janet [0000-0002-3887-4964], Apollo - University of Cambridge Repository

المصدر: Biochemical and Biophysical Research Communications

مصطلحات موضوعية: 0301 basic medicine, TG, thapsigargin, Male, X-Box Binding Protein 1, Protein Folding, XBP1, X-box-binding protein 1, B2M, beta-2-microglobulin, Apoptosis, Protein Homeostasis, Endoplasmic Reticulum, Kidney, Biochemistry, Naked mole-rat, ERAD, ER-associated degradation, Unfolded protein response, Mice, 0302 clinical medicine, UPR, unfolded protein response, NMR, naked mole-rat, Cells, Cultured, PDI4, Protein disulphide isomerase-like protein 4, biology, Chemistry, BLOC1S1, biogenesis of lysosome-related organelles complex 1 subunit 1, BiP, binding immunoglobulin protein, Endoplasmic Reticulum-Associated Degradation, Endoplasmic Reticulum Stress, Cell biology, medicine.anatomical_structure, GAPDH, glyceraldehyde-3-phosphate dehydrogenase, 030220 oncology & carcinogenesis, Female, ER stress, Protein homeostasis, 2019-20 coronavirus outbreak, ATF6, activating transcription factor 6, RNA Splicing, Longevity, Biophysics, IRE1, inositol-requiring enzyme 1, CHOP, C/EBP homologous protein, Protein Serine-Threonine Kinases, TU, tunicamycin, Article, 03 medical and health sciences, Mole, medicine, Animals, Molecular Biology, HERPUD1, Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein, PERK, protein kinase R-like ER kinase, Mole Rats, Cell Biology, Fibroblasts, biology.organism_classification, RPL13A, ribosomal protein L13a, HPRT1, hypoxanthine phosphoribosyltransferase 1, Ageing, 030104 developmental biology, Proteostasis, Gene Expression Regulation, SYVN1, E3 ubiquitin-protein ligase synoviolin, RIDD, regulated IRE1-dependent decay

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dda9bdff854e0eaf02e114030ccd53cdTest
https://www.repository.cam.ac.uk/handle/1810/307289Test

المؤلفون: Brandyn D. Henriksbo, Kieran Kwok, Akhilesh K. Tamrakar, Wendy Chi, Yong Chen, Mark Heal, Nicole G. Barra, Kevin P. Foley, Yong Liu, Brittany M. Duggan, Jonathan D. Schertzer

المصدر: The Journal of Biological Chemistry

مصطلحات موضوعية: 0301 basic medicine, WT, wild type, obesity, medicine.medical_treatment, immunometabolism, Adipose tissue, Hormone-sensitive lipase, White adipose tissue, Biochemistry, TKI, tyrosine kinase inhibitor, TLR4, toll-like receptor 4, Mice, PVDF, polyvinylidene difluoride, chemistry.chemical_compound, UPR, unfolded protein response, 0302 clinical medicine, ERK, extracellular signal-regulated kinase, HSL, hormone sensitive lipase, Adipocyte, Adipocytes, cytokine, Insulin, SVF, stromal vascular fraction, FK565, heptanoyl-γ-D-glutamyl-L-meso-diamino-pimelyl-D-alanine, Phosphorylation, ABL, Abelson murine leukemia viral oncogene homolog, TNF, tumor necrosis factor, 0303 health sciences, Grp78/BiP, binding immunoglobulin protein or heat shock 70 kDa protein 5, biology, PGN, peptidoglycan, Chemistry, NF-κB, nuclear factor kappa-light-chain-enhancer of activated B cells, NF-kappa B, WAT, white adipose tissue, BMDM, bone-marrow-derived macrophage, Il(6), interleukin, XBP1, X-box binding protein 1, Adipose Tissue, Cytokines, LPS, lipopolysaccharide, ER stress, SEAP, secreted alkaline phosphatase, Signal Transduction, Research Article, Proto-oncogene tyrosine-protein kinase Src, AKO, adipose knockout, medicine.medical_specialty, ATF6, activating transcription factor 6, Lipolysis, IRE1, inositol-requiring enzyme 1, Protein Serine-Threonine Kinases, CHOP, C/EBP homologous protein, adipocyte, metabolic syndrome, 8-Br-cAMP, 8-bromoadenosine 3′,5′-cyclic monophosphate, ER, endoplasmic reticulum, endocrinology, HEK, human embryonic kidney, 03 medical and health sciences, Insulin resistance, lipid, 3T3-L1 Cells, TUDCA, tauroursodeoxycholic acid, Internal medicine, medicine, Animals, 4-PBA, 4-phenylbutyric acid, RIPK2, receptor interacting serine/threonine kinase 2, Kinase activity, Molecular Biology, Protein kinase B, 030304 developmental biology, Inflammation, ATGL, adipose triglyceride lipase, 030102 biochemistry & molecular biology, Macrophages, Membrane Proteins, Cell Biology, medicine.disease, Insulin receptor, 030104 developmental biology, PERK, protein kinase RNA-like ER kinase, Endocrinology, KirA6, IRE1α kinase inhibiting RNase attenuator 6, Akt, protein kinase B, biology.protein, Unfolded protein response, PKA, protein kinase A, Insulin Resistance, NOD, nucleotide-binding oligomerization domain-containing protein, 030217 neurology & neurosurgery

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2429737118413a4da08eeea23250a451Test
https://doi.org/10.1101/2020.04.07.030148Test

المؤلفون: Gi-Young Kim, Kyoung Tae Lee, Cheol Park, Seungheon Lee, Yung Hyun Choi, Ilandarage Menu Neelaka Molagoda, Rajapaksha Gedara Prasad Tharanga Jayasooriya, Matharage Gayani Dilshara

المصدر: Antioxidants, Vol 8, Iss 10, p 423 (2019)
Antioxidants
Volume 8
Issue 10

مصطلحات موضوعية: 0301 basic medicine, p53, Physiology, Clinical Biochemistry, TNF-related apoptosis-inducing ligand, medicine.disease_cause, Biochemistry, Article, pharmacology_toxicology, 03 medical and health sciences, 0302 clinical medicine, Downregulation and upregulation, medicine, death receptor 5, Molecular Biology, neoplasms, chemistry.chemical_classification, Reactive oxygen species, Gene knockdown, Chemistry, Endoplasmic reticulum, lcsh:RM1-950, Cell Biology, digestive system diseases, Cell biology, 030104 developmental biology, lcsh:Therapeutics. Pharmacology, indirubin-3′-monoxime, Apoptosis, 030220 oncology & carcinogenesis, Cancer cell, Tumor necrosis factor alpha, transcription factor C/EBP homologous protein, Oxidative stress

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b074690dfc7a7fba1f25195ddc844c7Test

المؤلفون: Miguel López, Rubén Nogueiras, Xabier Buqué, Maria J. Gonzalez-Rellan, Daniel Beiroa, Patricia Aspichueta, Uxia Fernandez, Begoña Porteiro, Rosalía Gallego, Carlos Dieguez, Guadalupe Sabio, Marcos F. Fondevila, Johan Fernø, Ana Senra, Alfonso Mora

المساهمون: Ministerio de Economía y Competitividad (España), Xunta de Galicia (España), Heise Vest RHF, Comunidad de Madrid (España), Basque Government (España), Fundación AstraZeneca, Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF), Unión Europea. Comisión Europea, Centro de Investigación Biomedica en Red - CIBER

المصدر: Molecular Metabolism, Vol 8, Iss, Pp 132-143 (2018)
Molecular Metabolism
Repisalud
Instituto de Salud Carlos III (ISCIII)

مصطلحات موضوعية: 0301 basic medicine, pIRE, Inositol-requiring enzyme 1 α, pJNK, phospho c-Jun N-terminal kinase, ACC, acetyl-CoA carboxylase, AST, aspartate aminotransferase, XBP1s, X-box binding protein 1, Abcd1, ATP binding cassette subfamily D member 1, Pharmacology, ER stress, endoplasmic reticulum stress, NFκβ, nuclear factor kappa b, FA, free fatty acid, Mice, Liver disease, UPR, unfolded protein response, 0302 clinical medicine, HFD, high fat diet, Non-alcoholic Fatty Liver Disease, Nonalcoholic fatty liver disease, DG, diacylglycerol, Topoisomerase II Inhibitors, IL6, initerleukin 6, Beta oxidation, Acadm, acyl-CoA deshydrogenase, medium chain, GFP, green fluorescent protein, IL10, interleukin 10, Acox, acyl-CoA oxidase 1, TG, triglyceride, Ad, adenovirus, Hep G2 Cells, Acadl, acyl-CoA deshydrogenase, long-chain, i.p., intraperitoneal, FAS, fatty acid synthase, 3. Good health, Liver, Pparα, peroxisome proliferator activated receptor alpha, JNK, c-Jun N-terminal kinase, Lipogenesis, DOX, Doxorubicin, DN, dominant negative, Original Article, ApoB, apolipoprotein b, Quer, quercetin, NAFLD, non-alcoholic fatty liver disease, lcsh:Internal medicine, ASM, acid-soluble metabolites, NASH, non-alcoholic steatohepatitis, TNFα, tumor necrosis factor alpha, GAPDH, glyceraldehyde-3-phosphate deshydrogenase, AUC, area under curve, Diet, High-Fat, Cell Line, SPF, specific pathogen free room, 03 medical and health sciences, GTT, glucose test tolerance, ALT, alanine aminotransferase, AAV8, adeno-associated virus serotype 8, medicine, Animals, Humans, Obesity, EC, sterified cholesterol, lcsh:RC31-1245, Molecular Biology, MCD, methionine-choline deficient diet, CHOP, C/EBP-homologous protein, Inflammation, business.industry, OA, oleic acid, Lipid metabolism, DIO, diet-induced obesity, Cell Biology, Lipid Metabolism, medicine.disease, CDHFD, choline-deficient high fat diet, Mice, Inbred C57BL, 030104 developmental biology, Doxorubicin, pACC, phospho acetyl-CoA carboxylase, Hepatic stellate cell, BSA, bovine serum albumin, Tumor Suppressor Protein p53, Steatohepatitis, Steatosis, business, Fatp2, solute carrier family 27 (fatty acid transporter) member 2, IL1β, interleukin 1beta, 030217 neurology & neurosurgery, ITT, insulin test tolerance

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df7642e1971aebb46c881386960e7affTest
http://www.sciencedirect.com/science/article/pii/S2212877817310116Test