المؤلفون: Compton, Shelby E., Kitchen-Goosen, Susan M., DeCamp, Lisa M., Lau, Kin H., Mabvakure, Batsirai, Vos, Matthew, Williams, Kelsey S., Wong, Kwok-Kin, Shi, Xiaobing, Rothbart, Scott B., Krawczyk, Connie M., Jones, Russell G.

المصدر: Molecular Cell ; volume 83, issue 11, page 1872-1886.e5 ; ISSN 1097-2765

مصطلحات موضوعية: Cell Biology, Molecular Biology

الإتاحة: https://doi.org/10.1016/j.molcel.2023.04.017Test
https://api.elsevier.com/content/article/PII:S1097276523002885?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S1097276523002885?httpAccept=text/plainTest

المؤلفون: LeBoeuf, Sarah E., Wu, Warren L., Karakousi, Triantafyllia R., Karadal, Burcu, Jackson, S. RaElle, Davidson, Shawn M., Wong, Kwok-Kin, Koralov, Sergei B., Sayin, Volkan I., Papagiannakopoulos, Thales

المساهمون: American Cancer Society, National Institutes of Health

المصدر: Cell Metabolism ; volume 31, issue 2, page 339-350.e4 ; ISSN 1550-4131

مصطلحات موضوعية: Cell Biology, Molecular Biology, Physiology

الإتاحة: https://doi.org/10.1016/j.cmet.2019.11.012Test
https://api.elsevier.com/content/article/PII:S1550413119306199?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S1550413119306199?httpAccept=text/plainTest

المؤلفون: Eliades, Philip, Abraham, Brian J., Ji, Zhenyu, Miller, David M., Christensen, Camilla L., Kwiatkowski, Nicholas, Kumar, Raj, Njauw, Ching Ni, Taylor, Michael, Miao, Benchun, Zhang, Tinghu, Wong, Kwok-Kin, Gray, Nathanael S., Young, Richard A., Tsao, Hensin

المصدر: Journal of Investigative Dermatology ; volume 138, issue 7, page 1582-1590 ; ISSN 0022-202X

مصطلحات موضوعية: Cell Biology, Dermatology, Molecular Biology, Biochemistry

الإتاحة: https://doi.org/10.1016/j.jid.2017.09.056Test
https://api.elsevier.com/content/article/PII:S0022202X18301064?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S0022202X18301064?httpAccept=text/plainTest

المؤلفون: Gao, Yang, Zhang, Tinghu, Terai, Hideki, Ficarro, Scott B., Kwiatkowski, Nicholas, Hao, Ming-Feng, Sharma, Bandana, Christensen, Camilla L., Chipumuro, Edmond, Wong, Kwok-kin, Marto, Jarrod A., Hammerman, Peter S., Gray, Nathanael S., George, Rani E.

المساهمون: Friends for Life Neuroblastoma, NIH, Department of Defense Translational Team Science

المصدر: Cell Chemical Biology ; volume 25, issue 2, page 135-142.e5 ; ISSN 2451-9456

مصطلحات موضوعية: Clinical Biochemistry, Drug Discovery, Pharmacology, Molecular Biology, Molecular Medicine, Biochemistry

الإتاحة: https://doi.org/10.1016/j.chembiol.2017.11.007Test
https://api.elsevier.com/content/article/PII:S2451945617304245?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S2451945617304245?httpAccept=text/plainTest

المؤلفون: Zeng, Mei, Lu, Jia, Li, Lianbo, Feru, Frederic, Quan, Chunshan, Gero, Thomas W., Ficarro, Scott B., Xiong, Yuan, Ambrogio, Chiara, Paranal, Raymond M., Catalano, Marco, Shao, Jay, Wong, Kwok-Kin, Marto, Jarrod A., Fischer, Eric S., Jänne, Pasi A., Scott, David A., Westover, Kenneth D., Gray, Nathanael S.

المساهمون: Astellas Pharma, DOD, Jimmy V Foundation, US Department of Energy, Office of Biological and Environmental Research

المصدر: Cell Chemical Biology ; volume 24, issue 8, page 1005-1016.e3 ; ISSN 2451-9456

مصطلحات موضوعية: Clinical Biochemistry, Drug Discovery, Pharmacology, Molecular Biology, Molecular Medicine, Biochemistry

الإتاحة: https://doi.org/10.1016/j.chembiol.2017.06.017Test
https://api.elsevier.com/content/article/PII:S2451945617302313?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S2451945617302313?httpAccept=text/plainTest

المؤلفون: Pan, Yuanwang, Han, Han, Labbe, Kristen E., Zhang, Hua, Wong, Kwok-Kin

المصدر: Oncogene ; volume 40, issue 16, page 2817-2829 ; ISSN 0950-9232 1476-5594

مصطلحات موضوعية: Cancer Research, Genetics, Molecular Biology

الإتاحة: https://doi.org/10.1038/s41388-021-01723-7Test
https://www.nature.com/articles/s41388-021-01723-7.pdfTest
https://www.nature.com/articles/s41388-021-01723-7Test

المؤلفون: Fan, Ying-Xin, Wong, Lily, Marino, Michael P., Ou, Wu, Shen, Yi, Wu, Wen Jin, Wong, Kwok-Kin, Reiser, Jakob, Johnson, Gibbes R.

المصدر: Journal of Biological Chemistry ; volume 288, issue 23, page 16895-16904 ; ISSN 0021-9258

مصطلحات موضوعية: Cell Biology, Molecular Biology, Biochemistry

الإتاحة: https://doi.org/10.1074/jbc.m112.434217Test
https://api.elsevier.com/content/article/PII:S0021925820536958?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S0021925820536958?httpAccept=text/plainTest

المؤلفون: Nabet, Behnam, Roberts, Justin M., Buckley, Dennis L., Paulk, Joshiawa, Dastjerdi, Shiva, Yang, Annan, Leggett, Alan L., Erb, Michael A., Lawlor, Matthew A., Souza, Amanda, Scott, Thomas G., Vittori, Sarah, Perry, Jennifer A., Qi, Jun, Winter, Georg E., Wong, Kwok-Kin, Gray, Nathanael S., Bradner, James E.

المصدر: Nature Chemical Biology ; volume 14, issue 5, page 431-441 ; ISSN 1552-4450 1552-4469

مصطلحات موضوعية: Cell Biology, Molecular Biology

الإتاحة: https://doi.org/10.1038/s41589-018-0021-8Test
http://www.nature.com/articles/s41589-018-0021-8Test
http://www.nature.com/articles/s41589-018-0021-8.pdfTest

المؤلفون: Artandi, Steven E., Merrell, Kevin, Avitahl, Nicole, Wong, Kwok-Kin, Calame, Kathryn

مصطلحات موضوعية: MOLECULAR BIOLOGY

الوصف: TFE3 is a basic-helix-loop-helix-zipper (bHLHZIP) domain-containing protein that binds μE3 sites in regulatory elements in the immunoglobulin heavy chain gene. The protein is a transcriptional activator that is expressed in vivo as two alternately spliced isoforms with different activating properties: TFE3L contains an N-terminal acidic activation domain; TFE3S lacks this activation domain and is a dominant negative inhibftor of TFE3L We show that TFE3L and TFE3S contain a second, C-terminal activation domain rich in proline residues. This pro-rich activation domain has activity in a Gai4 fusion assay comparable to the N-terminal acidic activation domain present in TFE3L The TFE3 pro-rich activation domain contains regions of strong homology with the related proteins microphthaimia and WEB, suggesting that these regions are important for function. Using two different assays, we show that the N-and C-terminal activation domains of TFE3 act syner gisticaliy. This synergism explains in part the ability of TFE3S to act as a dominant negative. Our domain analysis of TFE3 is incorporated into a general structural model for the TFE3 protein that predicts that the activation domains of TFE3 will be widely separated in space.

وصف الملف: text/html

العلاقة: http://nar.oxfordjournals.org/cgi/content/short/23/19/3865Test; http://dx.doi.org/10.1093/nar/23.19.3865Test

الإتاحة: https://doi.org/10.1093/nar/23.19.3865Test
http://nar.oxfordjournals.org/cgi/content/short/23/19/3865Test

المؤلفون: Lau, Allison N, Curtis, Stephen J, Fillmore, Christine M, Rowbotham, Samuel P, Mohseni, Morvarid, Wagner, Darcy E, Beede, Alexander M, Montoro, Daniel T, Sinkevicius, Kerstin W, Walton, Zandra E, Barrios, Juliana, Weiss, Daniel J, Camargo, Fernando D, Wong, Kwok‐Kin, Kim, Carla F

المصدر: The EMBO Journal ; volume 33, issue 13, page 1502-1502 ; ISSN 0261-4189 1460-2075

مصطلحات موضوعية: General Immunology and Microbiology, General Biochemistry, Genetics and Molecular Biology, Molecular Biology, General Neuroscience

الإتاحة: https://doi.org/10.15252/embj.201488991Test