المؤلفون: Melissa A. Marton, Joshua Gould, Alykhan F. Shamji, Levi A. Garraway, Andrew L. Kung, Yan Ling Zhang, Wendy Winckler, Kenneth N. Ross, Pablo Tamayo, Stuart L. Schreiber, Griselda Metta Yvone, Michelle Palmer, Todd R. Golub, Aristotle M. Mannan, Andrew Crenshaw, Aviad Tsherniak, Bang Wong, Michael Foley, Barbara A. Weir, Channing Yu, Bradley Taylor

المصدر: Nature biotechnology
Nature biotechnology, vol 34, iss 4

مصطلحات موضوعية: 0301 basic medicine, Genotyping Techniques, Phenotypic screening, Drug Resistance, Biomedical Engineering, Bioengineering, Computational biology, Biology, Applied Microbiology and Biotechnology, Article, Cell Line, Mice, 03 medical and health sciences, 0302 clinical medicine, In vivo, Cell Line, Tumor, Neoplasms, Genotype, medicine, Animals, DNA Barcoding, Taxonomic, Humans, Tumor, Taxonomic, High-Throughput Nucleotide Sequencing, Cancer, medicine.disease, Small molecule, Molecular biology, DNA Barcoding, 3. Good health, 030104 developmental biology, Cell killing, Drug Resistance, Neoplasm, Cell culture, 030220 oncology & carcinogenesis, Neoplasm, Molecular Medicine, Erlotinib, Biotechnology, medicine.drug

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54d42661725f8e3900a3bb52d9babac5Test
https://doi.org/10.1038/nbt.3460Test

المؤلفون: Ding Li, Esther Elishaev, Linda Dao, Juok Cho, Alexei Protopopov, Heather Schmidt, Tod D. Casasent, Bobbie S. Gostout, P.J. DiSaia, Jacqueline E. Schein, J. Todd Auman, Jay Bowen, S. Onur Sumer, Beth Y. Karlan, Gordon Saksena, Prachi Kothiyal, Robert E. Pyatt, Theodore C. Goldstein, Lisle E. Mose, Paul J. Goodfellow, Brenda Ayala, Nilsa C. Ramirez, Thomas Barr, Payal Sipahimalani, Gordon B. Mills, Rebecca Carlsen, Linda Van Le, Andy Chu, Peter W. Laird, Russell Broaddus, Helga B. Salvesen, Sam Ng, Cyriac Kandoth, Christopher Adams, Yiling Lu, Donghui Tan, Peter White, Lori Boice, Saianand Balu, Daniel DiCara, Robert A. Holt, Christopher C. Benz, Shi Yan, Joel S. Parker, Jessica Frick, Adrian Ally, Boris Winterhoff, Pamela M. Pollock, Patrick Plettner, Ethan Cerami, Angela Tam, Katherine A. Hoadley, Melissa Hart-Kothari, Robert C. Onofrio, John N. Weinstein, Sheila Reynolds, David Haussler, Kristian Cibulskis, Charles M. Perou, Timothy J. Triche, Rehan Akbani, Jeff Roach, Michael Mayo, Ranabir Guin, W. Kimryn Rathmell, Carmen Helsel, Junyuan Wu, Will Mallard, Nandita Barnabas, Todd Pihl, Ruibin Xi, Nianxiang Zhang, David Mallery, Douglas A. Levine, Aaron D. Black, David I. Heiman, Sugy Kodeeswaran, Lynda Chin, Guoyan Liu, Mark E. Borowsky, Daniel J. Weisenberger, Yuexin Liu, Hailei Zhang, Kenna R. Mills Shaw, Anna K. Unruh, Andrew Berchuck, Michael Button, Noreen Dhalla, Bryan Hernandez, Rayna K. Matsuno, David G. Mutch, Chen Wang, Teresa R. Tabler, Yaron S.N. Butterfield, Jeff Gentry, Stuart R. Jefferys, Thomas Grossman, Kelley Kneile, Fanny Dao, Scot Waring, Barbara Tabak, Eric E. Snyder, Eric S. Lander, Richard A. Moore, David J. Dooling, David Van Den Berg, Jiabin Tang, Piotr A. Mieczkowski, Victoria Blanc, Wei Zhang, Inanc Birol, Harkness Kuck, Mathew G. Soloway, Johanna Gardner, Gary Witkin, Sahil Seth, Heidi J. Sofia, B. Arman Aksoy, Nikolaus Schultz, Marco A. Marra, Andrew D. Cherniack, D L Rotin, Anders Jacobsen, Erik Zmuda, Candace Carter, Christina Yau, Stephen C. Benz, Alexander A. Green, Michael D. Topal, Jean MacKenzie, Elena Nemirovich-Danchenko, Nicholas J. Petrelli, Dana Nicholson, Eve Shinbrot, Han Liang, Rameen Beroukhim, Charlenia Berry-Green, Kristin G. Ardlie, Joan Pontius, David Pot, Ari B. Kahn, Marc T. Goodman, Yevgeniy Antipin, Christopher Szeto, Jianhua Zhang, Ilya Shmulevich, Lori Huelsenbeck-Dill, Steven J.M. Jones, Carrie Sougnez, Kristen M. Leraas, Pei Lin, Robert A. Soslow, Erin Curley, Leigh B. Thorne, Hye Jung E. Chun, Michael S. Lawrence, Michelle O'Laughlin, Moiz S. Bootwalla, Lixing Yang, Mark A. Jensen, Rajiv Dhir, David A. Wheeler, C. Blake Gilks, Jianjiong Gao, Lisa Wise, Giovanni Ciriello, Joelle Kalicki-Veizer, Shaowu Meng, Mei Huang, Elaine R. Mardis, Faina Bogomolniy, Kai Ye, Jenny Lester, Lihua Zou, Hollie A. Harper, Robert Edwards, Ronglai Shen, Xiaojia Ren, Nils Weinhold, Harshad S. Mahadeshwar, Sandra Orsulic, Tom Bodenheimer, Zhenlin Ju, Chris Wakefield, Scott Frazer, John M. S. Bartlett, Gideon Dresdner, Hui Shen, Deepak Srinivasan, Aaron Hobensack, Cynthia McAllister, Marc Ladanyi, Tanja Davidsen, Lucinda Fulton, Michael D. McLellan, Richard K. Wilson, Zeng Dong, Olga Potapova, Sean C. Dowdy, Rui Jing, Kristin K. Zorn, Robert S. Fulton, Matti Annala, Chris Sander, Michael S. Noble, Benjamin Gross, Janae V. Simons, Phillip H. Lai, Laura Monovich, Andrew J. Mungall, Peter J. Park, Fedor Moiseenko, Liming Yang, Gad Getz, John Deardurff, Matthew Meyerson, Jeremy Parfitt, A. Gordon Robertson, Bradley M. Broom, Blaise A. Clarke, Greg Eley, Jennifer O. Fisher, Andrey Sivachenko, Narciso Olvera, Carrie Hirst, Adam M. Farkas, Karuna Garg, Wendy Winckler, Eric Chuah, Stacey Gabriel, Michael E. Carney, Stephen B. Baylin, Doug Voet, Miruna Balasundaram, Christine Czerwinski, Daphne W. Bell, Richard Varhol, Alexandra Meuter, Alan P. Hoyle, Darlene Lee, Elizabeth Buda, Li Ding, Xingzhi Song, Steven E. Schumacher, Anna L. Chu, Attila Teoman, Mary Iacocca, Semin Lee, Rileen Sinha, Itai Pashtan, Haiyan I. Li, Mikhail Abramov, Mark S. Guyer, Robert Penny, Margi Sheth, Scott L. Carter, Corbin D. Jones, Michael J. Birrer, Julie M. Gastier-Foster, D. Neil Hayes, Nathan Vanhoose, Brenda Rabeno, Raju Kucherlapati, Martin L. Ferguson, Joshua M. Stuart, Steve E. Kalloger, Mark G. Cadungog, Petar Stojanov, Tara M. Lichtenberg, Bradley A. Ozenberger, Angela Hadjipanayis, Barry S. Taylor, Boris Reva

المساهمون: Massachusetts Institute of Technology. Department of Biology, Lander, Eric S., Park, Peter J.

المصدر: Nature
PMC

مصطلحات موضوعية: DNA Copy Number Variations, endocrine system diseases, ARID1A, DNA Mutational Analysis, Breast Neoplasms, Biology, medicine.disease_cause, Article, Uterine serous carcinoma, 03 medical and health sciences, 0302 clinical medicine, medicine, Humans, PTEN, Exome, Poly-ADP-Ribose Binding Proteins, neoplasms, 030304 developmental biology, Chromosome Aberrations, Ovarian Neoplasms, 0303 health sciences, Endometrial intraepithelial neoplasia, Multidisciplinary, Genome, Human, Microsatellite instability, DNA Polymerase II, Genomics, medicine.disease, Molecular biology, female genital diseases and pregnancy complications, Endometrial Neoplasms, 3. Good health, DNA-Binding Proteins, Gene Expression Regulation, Neoplastic, Serous fluid, 030220 oncology & carcinogenesis, DNA methylation, Cancer research, biology.protein, Female, KRAS, Signal Transduction, Transcription Factors

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26da1e5ab2b011629d8910cfd5a4a5b1Test
https://doi.org/10.1038/nature12113Test

المؤلفون: Michael S. Lawrence, Kwok-Kin Wong, D. R. Mani, Xiaohong Zhang, Heidi Greulich, Tzu-Hsiu Chen, Bethany Kaplan, Gad Getz, Alice H. Berger, Michael J. Eck, Se-Hoon Lee, Jacob D. Jaffe, Lauren Ambrogio, David A. Frank, Philipp Mertins, Wendy Winckler, Shantanu Banerji, Steven A. Carr, Jinghui Zhang, Matthew Meyerson, Nam Pho, Marcin Imielinski, William C. Hahn, Cai-Hong Yun, Sarah R. Walker, Jeonghee Cho, Kumiko E. Tanaka, Rachel G. Liao

المصدر: Proceedings of the National Academy of Sciences. 109:14476-14481

مصطلحات موضوعية: Lung Neoplasms, Receptor, ErbB-2, Immunoblotting, Adenocarcinoma of Lung, Adenocarcinoma, SH2 domain, Tropomyosin receptor kinase C, Receptor tyrosine kinase, Mice, chemistry.chemical_compound, Cell Movement, Tandem Mass Spectrometry, Animals, Cloning, Molecular, Phosphorylation, Alleles, DNA Primers, Multidisciplinary, biology, Tyrosine phosphorylation, Biological Sciences, Molecular biology, Protein Structure, Tertiary, Retroviridae, chemistry, Mutation, ROR1, NIH 3T3 Cells, biology.protein, Dimerization, Tyrosine kinase, Platelet-derived growth factor receptor, Proto-oncogene tyrosine-protein kinase Src

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c515f2e4b7375040a3b03368ee396169Test
https://doi.org/10.1073/pnas.1203201109Test

المؤلفون: Kathy Stirrups, Inga Prokopenko, Jeanette Erdmann, Jun Ding, Serena Sanna, Patricia B. Munroe, Ramaiah Nagaraja, Antonella Mulas, Christian Fuchsberger, Cameron D. Palmer, Simon C. Potter, Ruth J. F. Loos, Nicole Soranzo, Tuomas O. Kilpeläinen, Michael Boehnke, Sekar Kathiresan, Francesco Cucca, David Altshuler, Hyun Min Kang, Melissa Parkin, Neil Robertson, Heribert Schunkert, Timothy M. Frayling, Gonçalo R. Abecasis, Arne Pfeufer, Toby Johnson, Joshua C. Randall, Mark I. McCarthy, Joel N. Hirschhorn, Nilesh J. Samani, Anne U. Jackson, Tanya M. Teslovich, Eleanor Wheeler, Benjamin F. Voight, Yun Li, Carlo Sidore, Panagiotis Deloukas, N P Burtt, Nigel W. Rayner, Richa Saxena, Peter S. Chines, Jared Maguire, Wendy Winckler, Cecilia M. Lindgren, Andrew P. Morris, Iris M. Heid, Christopher Newton-Cheh, Inês Barroso, Elizabeth K. Speliotes

المصدر: PLoS Genet. 8:e1002793 (2012)
PLoS Genetics, Vol 8, Iss 8, p e1002793 (2012)
PLoS Genetics

مصطلحات موضوعية: Cancer Research, Genotyping Techniques, Genome-wide association study, 030204 cardiovascular system & hematology, QH426-470, Cardiovascular, 0302 clinical medicine, Endocrinology, Gene Frequency, Genetics (clinical), Oligonucleotide Array Sequence Analysis, 2. Zero hunger, Genetics, 0303 health sciences, Anthropometry, Statistics, 3. Good health, Phenotype, Cardiovascular Diseases, Medicine, Research Article, Genotype, Quantitative Trait Loci, Genomics, Single-nucleotide polymorphism, Quantitative trait locus, Biology, Polymorphism, Single Nucleotide, 03 medical and health sciences, SNP, Humans, Metabolomics, Molecular Biology, Genotyping, Ecology, Evolution, Behavior and Systematics, Alleles, 030304 developmental biology, Genetic association, Diabetic Endocrinology, 0604 Genetics, Genome, Human, Human Genetics, Diabetes Mellitus Type 2, Diabetes Mellitus, Type 2, Metabolic Disorders, Mathematics, Genome-Wide Association Study, Developmental Biology

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6b37c5626e6089342d54f61300353c4Test
https://ora.ox.ac.uk/objects/uuid:00d09741-e53b-4d8b-9852-aae6b9fc0ab7Test

المؤلفون: Wendy Winckler, Roman K. Thomas, Thomas LaFramboise

المصدر: Bioinformatics. 25:722-728

مصطلحات موضوعية: Statistics and Probability, Gene Dosage, Copy number analysis, Computational biology, Biology, Biochemistry, Genome, Neoplasms, Humans, Sensitivity (control systems), Autistic Disorder, Statistical theory, Molecular Biology, Oligonucleotide Array Sequence Analysis, Genetics, Hybridization probe, Rank (computer programming), Nonparametric statistics, Computational Biology, Genetic Variation, DNA, Original Papers, Computer Science Applications, Computational Mathematics, Computational Theory and Mathematics, Comparative genomic hybridization

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::119e9a0ae2181e53119e10030a11b536Test
https://doi.org/10.1093/bioinformatics/btp063Test

المؤلفون: Gad Getz, Andrey Sivachenko, Michael R. Reich, Marc-Danie Nazaire, Chris Williams, Joshua Z. Levin, Wendy Winckler, Timothy Fennell, David S. DeLuca

المصدر: Bioinformatics

مصطلحات موضوعية: Quality Control, Statistics and Probability, Downstream (software development), media_common.quotation_subject, Biology, computer.software_genre, Biochemistry, Modularity, World Wide Web, Software, Quality (business), Molecular Biology, Gene Library, media_common, Internet, Sequence Analysis, RNA, business.industry, Gene Expression Profiling, High-Throughput Nucleotide Sequencing, Quality control, Genome Analysis, Pipeline (software), Computer Science Applications, Applications Note, Computational Mathematics, Computational Theory and Mathematics, RNA, Ribosomal, Data quality, Key (cryptography), RNA, Data mining, business, computer

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::652b3a8b46f2fd58518719a21bddae96Test
https://doi.org/10.1093/bioinformatics/bts196Test

المؤلفون: Scott Mahan, Gad Getz, Antje Sucker, Douglas Voet, Gordon Saksena, Rui Jing, Rhamy Zeid, Michael S. Lawrence, Jennifer A. Wargo, Xiaojia Ren, Scott L. Carter, Stephan N. Wagner, Jordi Barretina, Todd R. Golub, Nikhil Wagle, Trevor J. Pugh, Alexei Protopopov, Stacey Gabriel, Hailei Zhang, Wendy Winckler, Jennifer Baldwin, Kristian Cibulskis, Nicolas Stransky, Papia Ghosh, Yotam Drier, Alex H. Ramos, Elizabeth Nickerson, Levi A. Garraway, Timothy P. Heffernan, Meredith A. Singer, Melissa Parkin, Michael F. Berger, Elena S Ivanova, Matthew Meyerson, Dirk Schadendorf, Lynda Chin, Carrie Sougnez, Eric S. Lander, Yonathan Lissanu Deribe, Robert C. Onofrio, Lauren Ambrogio, Andrey Sivachenko, Daniel Auclair, Ian R. Watson, Kristin G. Ardlie, Eran Hodis, Petar Stojanov, Timothy Fennell

المساهمون: Massachusetts Institute of Technology. Department of Biology, Whitehead Institute for Biomedical Research, Lander, Eric S.

المصدر: eLife
PMC
Nature

مصطلحات موضوعية: driver mutations, Ultraviolet Rays, DNA Mutational Analysis, Medizin, Biology, medicine.disease_cause, Article, Chromosome Breakpoints, medicine, melanoma, PTEN, Guanine Nucleotide Exchange Factors, Humans, Mutation frequency, Human Biology and Medicine, Gene, mouse, Mutation, cancer genomics, Multidisciplinary, Genome, Human, Melanoma, Point mutation, methodology, Oncogenes, Cell Biology, medicine.disease, Molecular biology, Gene Expression Regulation, Neoplastic, Mutagenesis, Registered Report, biology.protein, Sunlight, Reproducibility Project: Cancer Biology, Melanocytes, Human genome, Ectopic expression, DNA Damage

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9701c9c4ae74a8f7ad513ae832f599dcTest
https://pubmed.ncbi.nlm.nih.gov/25490935Test

المؤلفون: William R. Sellers, Rameen Beroukhim, Barbara A. Weir, Matthew Meyerson, Levi A. Garraway, Wendy Winckler, Cheng Li

المساهمون: Broad Institute of MIT and Harvard, Harvard University--MIT Division of Health Sciences and Technology, Meyerson, Matthew L., Beroukhim, Rameen, Weir, Barbara A., Winckler, Wendy, Garraway, Levi A.

المصدر: BioMed Central Ltd
BMC Bioinformatics
BMC Bioinformatics, Vol 9, Iss 1, p 204 (2008)

مصطلحات موضوعية: Molecular Sequence Data, 0206 medical engineering, Gene Dosage, Copy number analysis, Single-nucleotide polymorphism, 02 engineering and technology, Biology, lcsh:Computer applications to medicine. Medical informatics, Molecular Inversion Probe, Polymorphism, Single Nucleotide, Sensitivity and Specificity, Biochemistry, 03 medical and health sciences, Structural Biology, Humans, SNP, lcsh:QH301-705.5, Molecular Biology, Oligonucleotide Array Sequence Analysis, 030304 developmental biology, Genetics, 0303 health sciences, Base Sequence, Applied Mathematics, Genetic Variation, DNA, Neoplasm, Tag SNP, 3. Good health, Computer Science Applications, SNP genotyping, lcsh:Biology (General), lcsh:R858-859.7, Human genome, Algorithms, 020602 bioinformatics, Research Article, SNP array

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c54d4e449953e79de1c1d13fa7b323bTest
http://hdl.handle.net/1721.1/58684Test

المؤلفون: Philipp Mertins, Sarah R. Walker, Gad Getz, Matthew Meyerson, Michael S. Lawrence, Wendy Winckler, Steven A. Carr, Tzu-Hsiu Chen, Shanatanu Banerji, Marcin Imielinski, Heidi Greulich, Cai-Hong Yun, Kumiko Tanaka, Kwok-Kin Wong, David John Frank, Michael J. Eck, Jacob D. Jaffe, Bethany Kaplan

المصدر: Cancer Research. 72:1-1

مصطلحات موضوعية: Cancer Research, Oncology, Protein kinase domain, Kinase, Stable isotope labeling by amino acids in cell culture, Extracellular, Phosphorylation, Receptor Tyrosine Kinase Gene, Tyrosine, Biology, Autocrine signalling, Molecular biology

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::e5c2926292b6146ccf8806d121e8cfa2Test
https://doi.org/10.1158/1538-7445.am2012-1Test

المؤلفون: Benjamin F. Voight, Hyun Min Kang, Jun Ding, Cameron D. Palmer, Carlo Sidore, Peter S. Chines, Noël P. Burtt, Christian Fuchsberger, Yanming Li, Jeanette Erdmann, Timothy M. Frayling, Iris M. Heid, Anne U. Jackson, Toby Johnson, Tuomas O. Kilpeläinen, Cecilia M. Lindgren, Andrew P. Morris, Inga Prokopenko, Joshua C. Randall, Richa Saxena, Nicole Soranzo, Elizabeth K. Speliotes, Tanya M. Teslovich, Eleanor Wheeler, Jared Maguire, Melissa Parkin, Simon Potter, N. William Rayner, Neil Robertson, Kathleen Stirrups, Wendy Winckler, Serena Sanna, Antonella Mulas, Ramaiah Nagaraja, Francesco Cucca, Inês Barroso, Panos Deloukas, Ruth J. F. Loos, Sekar Kathiresan, Patricia B. Munroe, Christopher Newton-Cheh, Arne Pfeufer, Nilesh J. Samani, Heribert Schunkert, Joel N. Hirschhorn, David Altshuler, Mark I. McCarthy, Gonçalo R. Abecasis, Michael Boehnke

المصدر: Europe PubMed Central
PLoS Genetics, Vol 9, Iss 4 (2013)
PLoS Genetics

مصطلحات موضوعية: Cancer Research, lcsh:Genetics, lcsh:QH426-470, Genetics, Correction, QH426-470, Molecular Biology, Genetics (clinical), Ecology, Evolution, Behavior and Systematics

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca09cbad0cc1c848c8aeacce19eb0c08Test
http://europepmc.org/abstract/PMC/PMC3636280Test