المؤلفون: Yvan Varisco, Anne Hamel, Nampally Sreenivasachary, Wolfgang Froestl, Valérie Giriens, Heiko Kroth, Pascal Benderitter, Andreas Muhs, Andrea Pfeifer, Paolo Paganetti

المصدر: Bioorganic & Medicinal Chemistry Letters. 26:3330-3335

مصطلحات موضوعية: 0301 basic medicine, Pyridines, Stereochemistry, Clinical Biochemistry, Pharmaceutical Science, 01 natural sciences, Biochemistry, Protein Aggregates, Structure-Activity Relationship, 03 medical and health sciences, chemistry.chemical_compound, β amyloid, Drug Discovery, Pyridine, Humans, Structure–activity relationship, Moiety, Molecular Biology, Amyloid beta-Peptides, Dose-Response Relationship, Drug, Molecular Structure, 010405 organic chemistry, Chemistry, Hydrogen bond, Organic Chemistry, 0104 chemical sciences, 030104 developmental biology, Molecular Medicine

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb9312584d8d514d20c50ae6f46c639fTest
https://doi.org/10.1016/j.bmcl.2016.05.040Test

المؤلفون: Andreas Muhs, Maria Pihlgren, Emma Fiorini, Andrea Pfeifer, Nathalie Chuard, Delphine Knittel, Valérie Giriens, Marija Vukicevic

المصدر: Alzheimer's & Dementia. 13

مصطلحات موضوعية: Amyloid β, Epidemiology, Health Policy, Molecular biology, Oligomer, Highly sensitive, Psychiatry and Mental health, Cellular and Molecular Neuroscience, chemistry.chemical_compound, Specific antibody, Monomer, Developmental Neuroscience, chemistry, Neurology (clinical), Geriatrics and Gerontology

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::a6b57fd7a7463d8379b00bc2646be936Test
https://doi.org/10.1016/j.jalz.2017.06.1277Test

المؤلفون: Nampally Sreenivasachary, Paolo Paganetti, Valérie Giriens, Luitgard Nagel-Steger, Markus Zweckstetter, Oskar Adolfsson, Andreas Muhs, Heiko Kroth, Maria Pihlgren, Andrea Pfeifer, Thomas Schrader, Sophie Lohmann, Yvan Varisco, Asad Jan, Nasrollah Rezaei-Ghaleh, María Pilar López-Deber, Annalisa Ansaloni, Hilal A. Lashuel, Wolfgang Froestl, Dieter Willbold

المصدر: Journal of Biological Chemistry
The journal of biological chemistry 287(41), 34786-34800 (2012). doi:10.1074/jbc.M112.357665
Kroth, H, Ansaloni, A, Varisco, Y, Jan, A, Sreenivasachary, N, Rezaei-Ghaleh, N, Giriens, V, Lohmann, S, López-Deber, M P, Adolfsson, O, Pihlgren, M, Paganetti, P, Froestl, W, Nagel-Steger, L, Willbold, D, Schrader, T, Zweckstetter, M, Pfeifer, A, Lashuel, H A & Muhs, A 2012, ' Discovery and structure activity relationship of small molecule inhibitors of toxic β-amyloid-42 fibril formation ', The Journal of biological chemistry, vol. 287, no. 41, pp. 34786-800 . https://doi.org/10.1074/jbc.M112.357665Test

مصطلحات موضوعية: 3-aminopyrazole, antagonists & inhibitors [Amyloid beta-Peptides], antagonists & inhibitors [Cytotoxins], antagonists & inhibitors [Peptide Fragments], Chemie, chemistry [Cytotoxins], Protein aggregation, Biochemistry, Protein Structure, Secondary, Hydrophobic effect, Structure-Activity Relationship, Protein structure, Cell Line, Tumor, mental disorders, Journal Article, Humans, Structure–activity relationship, Molecular Biology, chemistry.chemical_classification, Amyloid beta-Peptides, Cytotoxins, Chemistry, Research Support, Non-U.S. Gov't, In vitro toxicology, Molecular Bases of Disease, Hydrogen Bonding, Cell Biology, amyloid beta-protein (1-42), Small molecule, Peptide Fragments, Amino acid, chemistry [Peptide Fragments], ddc:540, chemistry [Pyrazoles], Pyrazoles, chemistry [Amyloid beta-Peptides], Hydrophobic and Hydrophilic Interactions, Linker

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4f1d6b8bb6eb1e9cd8d68fd89416ac0Test
https://hdl.handle.net/11858/00-001M-0000-000E-7305-311858/00-001M-0000-000E-7304-511858/00-001M-0000-000E-7300-DTest

المؤلفون: Maria Pihlgren, Andrea Pfeifer, Dorin Mlaki Ndao, Claude Nicolau, Marc Baldus, Deepak Nand, Rime Madani, David T. Hickman, María Pilar López-Deber, Luitgard Nagel-Steger, Andreas Muhs, Valérie Giriens, Annie St-Pierre, Dieter Willbold, Detlev Riesner, Alberto B. Silva, Hristina Karastaneva

المصدر: Journal of Biological Chemistry, 286(16), 13966. American Society for Biochemistry and Molecular Biology Inc.

مصطلحات موضوعية: Amyloid, Protein Folding, Magnetic Resonance Spectroscopy, Protein Conformation, Lipid-anchored protein, Peptide, Biology, Biochemistry, Epitope, Protein Structure, Secondary, chemistry.chemical_compound, Mice, Protein structure, Alzheimer Disease, Animals, Humans, Benzothiazoles, Neurodegeneration, Proteostasis Deficiencies, Molecular Biology, chemistry.chemical_classification, Vaccines, Circular Dichroism, Lipopeptide, Peptide Conformation, Cell Biology, Small molecule, Protein Structure, Tertiary, Mice, Inbred C57BL, Protein Misfolding, Thiazoles, chemistry, Immunoglobulin G, Liposomes, Protein Structure and Folding, Protein folding, Female, Peptides

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a337f57da46a893e698aab99ff2d80ecTest
https://pubmed.ncbi.nlm.nih.gov/21343310Test

المؤلفون: Luitgard Nagel-Steger, Valérie Giriens, Claude Nicolau, Andrea Pfeifer, Nathalie Chuard, Maria Pihlgren, Nadine Kolonko, Carine Meerschman, Roscoe O. Brady, Marie-Catherine Weingertner, Fred Van Leuven, Ingrid Van der Auwera, Andreas Muhs, Ruth Greferath, Masae Sugawara, David T. Hickman, Burkhard Bechinger, Detlev Riesner

المصدر: Proceedings of the National Academy of Sciences of the United States of America. 104(23)

مصطلحات موضوعية: Amyloid, Alzheimer Vaccines, Peptide, Enzyme-Linked Immunosorbent Assay, Mice, Transgenic, Epitope, Amyloid beta-Protein Precursor, Mice, Immune system, Antigen, Alzheimer Disease, Animals, Antigens, Nuclear Magnetic Resonance, Biomolecular, chemistry.chemical_classification, Analysis of Variance, Multidisciplinary, Amyloid beta-Peptides, biology, Brain, Recognition, Psychology, Biological Sciences, Isotype, Molecular biology, Peptide Fragments, Epitope mapping, chemistry, Immunology, Liposomes, biology.protein, Cytokines, Antibody, Oligopeptides, Epitope Mapping

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c9d72a7b24bbd53c642153317489165Test
https://pubmed.ncbi.nlm.nih.gov/17517595Test