المؤلفون: Maki Nakayama, Maikel Luis Colli, Yann Verdier, Noemi Brusco, Lut Overbergh, Mark J. Mamula, Aïsha Callebaut, Joëlle Vinh, Guido Sebastiani, Georgia Afonso, Laura Nigi, Matthieu Giraud, Barbara Brandao, Zhicheng Zhou, Sylvaine You, Alexia Carré, Mijke Buitinga, Sheena Pinto, Marie Eliane Azoury, Decio L. Eizirik, Francesco Dotta, Chantal Mathieu, Søren Buus, Roberto Mallone, Fatoumata Samassa, Ana Ines Lalanne, Magali Irla

المساهمون: Spectrométrie de Masse Biologique et Protéomique (USR3149 / FRE2032) (SMBP), Ecole Superieure de Physique et de Chimie Industrielles de la Ville de Paris (ESPCI Paris), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS), Université Paris sciences et lettres (PSL)

المصدر: Diabetes
Diabetes, American Diabetes Association, 2021, pp.db210259. ⟨10.2337/db21-0259⟩

مصطلحات موضوعية: chemistry.chemical_classification, 0303 health sciences, Endocrinology, Diabetes and Metabolism, Citrullination, 030209 endocrinology & metabolism, Peptide, Biology, Molecular biology, Epitope, 03 medical and health sciences, 0302 clinical medicine, chemistry, PADI2, PADI4, Internal Medicine, Cytotoxic T cell, [SDV.IMM]Life Sciences [q-bio]/Immunology, CD8, ComputingMilieux_MISCELLANEOUS, 030304 developmental biology, NOD mice

وصف الملف: Print-Electronic

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a38375b241b82cebe35b607398e6eeaTest
https://doi.org/10.2337/figshare.16654669Test

المؤلفون: Barbara Morschhaeuser, Thomas J. Hoffmann, Sheena Pinto, Martin Hornberger, Michael Albers, Christoph Steeneck, Simon Anderhub, Olaf Kinzel, Christina Sonnek, Marta Czekańska

المصدر: Bioorganicmedicinal chemistry letters. 33

مصطلحات موضوعية: Drug, media_common.quotation_subject, medicine.medical_treatment, Clinical Biochemistry, Pharmaceutical Science, 01 natural sciences, Biochemistry, chemistry.chemical_compound, Structure-Activity Relationship, Cancer immunotherapy, Drug Discovery, medicine, Potency, Humans, Indoleamine-Pyrrole 2,3,-Dioxygenase, Enzyme Inhibitors, Molecular Biology, Heme, media_common, ADME, chemistry.chemical_classification, Oxamic Acid, Dose-Response Relationship, Drug, Molecular Structure, 010405 organic chemistry, Organic Chemistry, Ligand (biochemistry), Small molecule, Combinatorial chemistry, Amides, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, Enzyme, chemistry, Molecular Medicine

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd4e4555cbfa9a8e4793f92782d8c9e6Test
https://pubmed.ncbi.nlm.nih.gov/33333163Test

المؤلفون: Christoph Steeneck, Olaf Kinzel, Simon Anderhub, Aurélie Mallinger, Marta Czekańska, Sheena Pinto, Barbara Morschhaeuser, Christina Sonnek, Martin Hornberger, Thomas J. Hoffmann, Michael Albers, Yansong Wang

المصدر: Bioorganic & Medicinal Chemistry Letters. 33:127738

مصطلحات موضوعية: Lipopolysaccharides, Clinical Biochemistry, Pharmaceutical Science, 01 natural sciences, Biochemistry, Bridged Bicyclo Compounds, Mice, Structure-Activity Relationship, chemistry.chemical_compound, Pharmacokinetics, Drug Discovery, medicine, Animals, Humans, Indoleamine-Pyrrole 2,3,-Dioxygenase, Enzyme Inhibitors, Molecular Biology, Heme, Kynurenine, ADME, Whole blood, Oxamic Acid, Dose-Response Relationship, Drug, Molecular Structure, Bicyclic molecule, 010405 organic chemistry, Organic Chemistry, Amides, In vitro, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, medicine.anatomical_structure, chemistry, Hepatocyte, Molecular Medicine

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::373dcfd00c06df0df2fd5d34994a7c3eTest
https://doi.org/10.1016/j.bmcl.2020.127738Test

المؤلفون: Thomas Blankenstein, Bruno Kyewski, Sheena Pinto, Dolores J. Schendel, Wolfgang Uckert, Susanne Wilde, Daniel Sommermeyer, Chloé Michel

المصدر: European Journal of Immunology. 44:2811-2821

مصطلحات موضوعية: integumentary system, Immunology, T-cell receptor, Biology, Molecular biology, Epitope, Interleukin 21, Antigen, Transcription (biology), Immunology and Allergy, Cytotoxic T cell, Central tolerance, neoplasms, CD8

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::3a44a0ba76d9fb411e37f23443bd8ff6Test
https://doi.org/10.1002/eji.201444499Test

المؤلفون: Stefanie Rösch, Bruno Kyewski, Klaus Hexel, Sheena Pinto, Jens Derbinski

المصدر: Proceedings of the National Academy of Sciences. 105:657-662

مصطلحات موضوعية: T cell, Locus (genetics), Thymus Gland, Autoimmune Diseases, Mice, Gene expression, medicine, Animals, Lactation, Gene, Mice, Knockout, Regulation of gene expression, Mice, Inbred C3H, Stochastic Processes, Multidisciplinary, biology, Caseins, Epithelial Cells, Biological Sciences, Milk Proteins, Autoimmune regulator, Molecular biology, medicine.anatomical_structure, Gene Expression Regulation, B7-1 Antigen, Lactalbumin, biology.protein, Female, Whey Acidic Protein, Central tolerance

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4054052ee86818f40e8a10740f41a8aaTest
https://doi.org/10.1073/pnas.0707486105Test

المؤلفون: Sheena Pinto, Slobodan Culina, Mathieu Armanet, Marie Eliane Azoury, Guido Sebastiani, Jean Paul Beressi, Maikel Luis Colli, Marco Bugliani, Yann Verdier, Roberto Mallone, Lars M. Steinmetz, Alexia Carré, Francesco Dotta, Gonzalez-Duque Sergio, Piero Marchetti, Noémie Corcos, Jean Valéry Turatsinze, Georgia Afonso, Decio L. Eizirik, Marc Diedisheim, Bruno Kyewski, Laura Nigi, Danièle Dubois-Laforgue, Raphael Scharfmann, Joëlle Vinh, Etienne Larger, Søren Buus, Graziella Bruno, Sylvaine You, Ana Inés Lalanne

المساهمون: Institut Cochin (IC UM3 (UMR 8104 / U1016)), Centre National de la Recherche Scientifique (CNRS)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM), Université Sorbonne Paris Cité (USPC), Spectrométrie de Masse Biologique et Protéomique (USR3149 / FRE2032) (SMBP), Ecole Superieure de Physique et de Chimie Industrielles de la Ville de Paris (ESPCI Paris), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS), Université Paris Descartes - Paris 5 (UPD5), Center for Diabetes Research and Welbio [Brussels, Belgium] (Medical Faculty), Université libre de Bruxelles (ULB), Department of Medicine, Surgery and Neuroscience [Siena, Italy] (Diabetes Unit), University Hospital of Siena [Italy]-Fondazione Umberto di Mario ONLUS [Siena, Italy]-Toscana Life Sciences [Siena, Italy], Division of Developmental Immunology [Heidelberg, Germany], German Cancer Research Center - Deutsches Krebsforschungszentrum [Heidelberg] (DKFZ), Department of Clinical and Experimental Medicine [Pisa, Italy], University of Pisa [Italy], Cell Therapy Unit [AP-HP Hôpital Saint-Louis], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris Diderot - Paris 7 (UPD7)-Groupe Hospitalier Saint Louis - Lariboisière - Fernand Widal [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Service de diabétologie [CHU Cochin], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Cochin [AP-HP], Hôpital Cochin [AP-HP], Department of Genetics [Stanford], Stanford Medicine, Stanford University-Stanford University, Genome Biology Unit [Heidelberg, Germany], European Molecular Biology Laboratory [Hinxton], Department of Immunology and Microbiology [Copenhagen], Faculty of Health and Medical Sciences, University of Copenhagen = Københavns Universitet (KU)-University of Copenhagen = Københavns Universitet (KU), Service de Diabétologie [CH Versailles André Mignot, Le Chesnay], Centre Hospitalier de Versailles André Mignot (CHV), Department of Medical Sciences [Turin, Italy] (DMS), University of Turin, This work was performed within the Département Hospitalo-Universitaire (DHU) AutHorS and supported by a PhD fellowship of the Ile-de-France CORDDIM and Aide aux Jeunes Diabétiques and by grants from the JDRF (1-PNF-2014-155-A-V, 2-SRA-2016-164-Q-R), the Agence Nationale de la Recherche (ANR-2015-CE17-0018-01), the Fondation pour la Recherche Médicale (DEQ20140329520), the Société Francophone du Diabète, the Association pour la Recherche sur le Diabète, and the Helmsley Charitable Trust Eisenbarth nPOD Award for Team Science (2015PG-T1D052) to R.M., Lilly and Fondation Bettencourt-Schueller to R.S., European Research Council (ERC-2012-AdG) to B.K., FRFSWelbio (CR-2015A-06) and NIH-NIDDK-HIRN Consortium (1UC4DK104166-01) to D.L.E., and Ile-de-France SESAME 2010 (10022268), the City of Paris, and ESPCI Paris to J.V. This project received funding from the Innovative Medicines Initiative 2 Joint Undertaking (INNODIA, 115797), which receives support from the EU Horizon 2020 program, the European Federation of Pharmaceutical Industries and Associations, JDRF, and the Helmsley Charitable Trust. This research was supported by nPOD, a collaborative T1D research project funded by JDRF. Organ Procurement Organizations partnering with nPOD are listed at www.jdrfnpod.org/ourpartners.php., ANR-15-CE17-0018,TIBET,LA PRESSION ENVIRONNEMENTALE SUR UNE IMAGE ALTEREE DU SOI IMMUNITAIRE : VERS LA PREDICTION ET LA PREVENTION DU DIABETE DE TYPE 1(2015), Mallone, Roberto, LA PRESSION ENVIRONNEMENTALE SUR UNE IMAGE ALTEREE DU SOI IMMUNITAIRE : VERS LA PREDICTION ET LA PREVENTION DU DIABETE DE TYPE 1 - - TIBET2015 - ANR-15-CE17-0018 - AAPG2015 - VALID, Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), University of Pisa - Università di Pisa, University of Copenhagen = Københavns Universitet (UCPH)-University of Copenhagen = Københavns Universitet (UCPH), Università degli studi di Torino = University of Turin (UNITO)

المصدر: Cell Metabolism
Cell Metabolism, Elsevier, 2018, 28 (6), pp.946-960. ⟨10.1016/j.cmet.2018.07.007⟩
Cell Metabolism, 28 (6
Cell Metabolism, 2018, 28 (6), pp.946-960. ⟨10.1016/j.cmet.2018.07.007⟩

مصطلحات موضوعية: 0301 basic medicine, Proteomics, endocrine system diseases, Corticotropin-Releasing Hormone, Physiology, type 1 diabetes, Epitopes, T-Lymphocyte, urocortin, CD8-Positive T-Lymphocytes, Epitope, Mice, 0302 clinical medicine, HLA Antigens, Physiologie générale, Cytotoxic T cell, Insulin, Urocortins, Antigen Presentation, epitope, Antigen processing, autoimmunity, 3. Good health, Islet Amyloid Polypeptide, human leukocyte antigen (HLA), Proprotein Convertase 2, Cytokines, [SDV.IMM]Life Sciences [q-bio]/Immunology, secretogranin, Preproinsulin, endocrine system, [SDV.IMM] Life Sciences [q-bio]/Immunology, antigen, preproinsulin, proconvertase, transpeptidation, Molecular Biology, Cell Biology, 030209 endocrinology & metabolism, Human leukocyte antigen, Biology, Cell Line, 03 medical and health sciences, Neuroendocrine Secretory Protein 7B2, Antigen, Downregulation and upregulation, Animals, Humans, Protein Precursors, Biologie moléculaire, 030104 developmental biology, Diabetes Mellitus, Type 1, Case-Control Studies, Immunology, Biologie cellulaire, Transcriptome, CD8, Biomarkers

وصف الملف: 2 full-text file(s): application/pdf; application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cff6e270c5bef0ee6ba99c23259793a6Test