المؤلفون: Marcus C. S. Lee, Edward Owen, James M. Murithi, Kerry McGowen, Beatriz Baragaña, Madeline R. Luth, Emma F. Carpenter, Jacquin C. Niles, Chris Walpole, Manu Vanaerschot, Rebecca E. K. Mandt, Sabine Ottilie, Ian H. Gilbert, Avinash S. Punekar, Charisse Flerida A. Pasaje, Krittikorn Kümpornsin, Aslı Akidil, João Pedro Pisco, Kelly Rubiano, Nimisha Mittal, David A. Fidock, Robert L. Summers, De Lin, Andy Plater, Sharon M. Shepherd, Elizabeth A. Winzeler, A. Hazel Dilmore, Andrew M. Shepherd, Amanda K. Lukens, Dyann F. Wirth, Madalyn Won, Josefine Striepen, Justin Munro, Manuel Llinás

المصدر: Cell Chemical Biology. 29:191-201.e8

مصطلحات موضوعية: Models, Molecular, Plasmodium falciparum, Clinical Biochemistry, Druggability, Acetate-CoA Ligase, Biochemistry, Antimalarials, chemistry.chemical_compound, Parasitic Sensitivity Tests, Drug Discovery, Chemogenomics, Humans, Epigenetics, Enzyme Inhibitors, Molecular Biology, Pharmacology, Gene knockdown, Molecular Structure, biology, Acetyl—CoA synthetase, biology.organism_classification, Malaria, Histone, chemistry, Acetylation, biology.protein, Molecular Medicine

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80e3028ee2d6c74bf0739d4ebecac7ebTest
https://doi.org/10.1016/j.chembiol.2021.07.010Test

المؤلفون: Jacquin C. Niles, Olalla Sanz, Anne-Catrin Uhlemann, Giulia Siciliano, Marcus C. S. Lee, Pietro Alano, Tomas Yeo, Michael J. Delves, Charisse Flerida A. Pasaje, Manuel Llinás, Sabine Ottilie, Louis Dwomoh, Kathryn J. Wicht, David A. Fidock, Megan J. Bird, Marla J. Giddins, Elizabeth A. Winzeler, Lauren B. Arendse, Nimisha Mittal, Emma F. Carpenter, T. R. Santha Kumar, Sonja Ghidelli-Disse, Natasha Spottiswoode, Sachel Mok, Edward Owen, Manu Vanaerschot, Kelly Chibale, James M. Murithi, Christian Doerig, Markus Bösche, Andrew B. Tobin

المصدر: Cell Chemical Biology

مصطلحات موضوعية: Proteomics, Clinical Biochemistry, Drug Resistance, Protozoan Proteins, Pharmacology, 01 natural sciences, Biochemistry, law.invention, Mice, malaria drug discovery, law, Drug Discovery, Tyrosine, Mice, Inbred BALB C, Gene knockdown, Kinase, Imidazoles, Phosphoproteomics, phosphoproteomics, Molecular Docking Simulation, Recombinant DNA, cardiovascular system, Molecular Medicine, Female, cGMP-dependent protein kinase (PKG), kinase, Plasmodium falciparum, Biology, Article, resistance, Antimalarials, Mediator, target identification, parasitic diseases, Cyclic GMP-Dependent Protein Kinases, Animals, Humans, Metabolomics, Protein kinase A, Molecular Biology, Life Cycle Stages, Binding Sites, conditional knockdown, 010405 organic chemistry, biology.organism_classification, chemoproteomics, 0104 chemical sciences, Hepatocytes

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d625bae4a60074eb3597e6c742453db2Test
https://eprints.gla.ac.uk/216135/1/216135.pdfTest

المؤلفون: David A. Fidock, Barbara H. Stokes, Piotr Cieplak, Yani Zhou, Krittikorn Kümpornsin, Sachel Mok, Jonathan Z. Long, Euna Yoo, Kenji L. Kurita, Ian T. Foe, Matthew Bogyo, Michael J. Boucher, Nina F. Gnädig, Anne-Catrin Uhlemann, Ouma Onguka, Tomas Yeo, Roger G. Linington, Stephanie M. Terrell, Christopher J. Schulze, Marcus C. S. Lee, Eranthie Weerapana

المصدر: Cell Chem Biol

مصطلحات موضوعية: Hydrolases, Clinical Biochemistry, Plasmodium falciparum, Drug Resistance, Protozoan Proteins, Drug resistance, Biology, 01 natural sciences, Biochemistry, Article, Serine, chemistry.chemical_compound, Antimalarials, parasitic diseases, Drug Discovery, medicine, Animals, Humans, Parasites, Malaria, Falciparum, Diet, Fat-Restricted, Molecular Biology, Pharmacology, Orlistat, Biological Products, Natural product, 010405 organic chemistry, Serine hydrolase, Lipid metabolism, biology.organism_classification, Bridged Bicyclo Compounds, Heterocyclic, Lipid Metabolism, Monoacylglycerol Lipases, Malaria, 0104 chemical sciences, Monoacylglycerol lipase, Mechanism of action, chemistry, Molecular Medicine, Click Chemistry, medicine.symptom

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8cd1de8040b695e68d20b488036ea2d8Test
https://pubmed.ncbi.nlm.nih.gov/32084335Test

المؤلفون: Marcus C. S. Lee, Maryia Karpiyevich, Sophie H. Adjalley, Heike Laman, Marco Mol, Gerbrand J. van der Heden van Noort, Bethany Mason, David B. Ascher, Katerina Artavanis-Tsakonas, Huib Ovaa

المساهمون: Ascher, David [0000-0003-2948-2413], Mason, Bethany [0000-0002-1157-0469], Laman, Heike [0000-0002-6089-171X], Apollo - University of Cambridge Repository

المصدر: PLoS Pathogens
PLoS Pathogens, Vol 15, Iss 10, p e1008086 (2019)
PLoS Pathogens, 15(10)

مصطلحات موضوعية: Plasmodium, NEDD8, Biochemistry, Ubiquitin, Medicine and Health Sciences, Biology (General), Malaria, Falciparum, Genetics, Protozoans, 0303 health sciences, Crystallography, biology, Hydrolysis, Physics, 030302 biochemistry & molecular biology, Chemical Reactions, Malarial Parasites, Eukaryota, Cell cycle, Condensed Matter Physics, 3. Good health, Enzymes, Chemistry, Physical Sciences, Crystal Structure, Ubiquitin Thiolesterase, Research Article, NEDD8 Protein, QH301-705.5, DNA repair, Ubiquitin-Protein Ligases, Immunology, Plasmodium falciparum, Microbiology, Cell Line, 03 medical and health sciences, Antimalarials, Virology, Parasite Groups, Parasitic Diseases, Solid State Physics, Humans, Amino Acid Sequence, Molecular Biology, 030304 developmental biology, Organisms, Ubiquitination, Biology and Life Sciences, Proteins, Protein Complexes, Proteasomes, RC581-607, biology.organism_classification, Parasitic Protozoans, HEK293 Cells, Proteasome, biology.protein, Enzymology, Parasitology, Neddylation, Immunologic diseases. Allergy, Apicomplexa

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5cca0d78db8b6476bfcfcbf93eec7eaTest
http://europepmc.org/articles/PMC6837540Test

المؤلفون: Manuel Llinás, David A. Fidock, Eva S. Istvan, Elizabeth A. Winzeler, Sabine Ottilie, James M. Murithi, Marcus C. S. Lee, Kelly Chibale, Daniel E. Goldberg, Edward Owen, Manu Vanaerschot

المصدر: Cell chemical biology. 27(2)

مصطلحات موضوعية: Clinical Biochemistry, Plasmodium falciparum, Druggability, Computational biology, Biology, Lumefantrine, 01 natural sciences, Biochemistry, chemistry.chemical_compound, Antimalarials, Chloroquine, Piperaquine, Drug Discovery, medicine, Humans, Metabolomics, Malaria, Falciparum, Molecular Biology, Atovaquone, Pharmacology, Life Cycle Stages, 010405 organic chemistry, Drug discovery, Mefloquine, biology.organism_classification, 3. Good health, 0104 chemical sciences, Mitochondria, chemistry, Electron Transport Chain Complex Proteins, Drug Design, Metabolome, Quinolines, Molecular Medicine, medicine.drug

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::986390d82f3fd8a60506373de3bb3953Test
https://pubmed.ncbi.nlm.nih.gov/32084336Test

المؤلفون: Amélie Le Bihan, David A. Fidock, Victoria C. Corey, Pietro Alano, Giulia Siciliano, Selina Bopp, Martine Clozel, Rachel G. Kasdin, Sergio Wittlin, Elizabeth A. Winzeler, Lucia Bertuccini, Mariana Justino de Almeida, Caroline L. Ng, Marcus C. S. Lee

المصدر: Molecular Microbiology. 101:381-393

مصطلحات موضوعية: 0301 basic medicine, biology, Mefloquine, 030106 microbiology, Plasmodium falciparum, Amodiaquine, Drug resistance, Pharmacology, medicine.disease, biology.organism_classification, Lumefantrine, Microbiology, 03 medical and health sciences, chemistry.chemical_compound, 030104 developmental biology, chemistry, parasitic diseases, medicine, Gametocyte, Artemisinin, Molecular Biology, Malaria, medicine.drug

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::e95e7af3f97a2378e235c43d765da3d5Test
https://doi.org/10.1111/mmi.13397Test

المؤلفون: Robin B. Chan, Daisy Hjelmqvist, Olivia Coburn-Flynn, Eric H. Ekland, David A. Fidock, Natasha Spottiswoode, Sonia Gulati, Bowen Zhou, Tilla S. Worgall, Gilbert Di Paolo, Kelly V. Ruggles, Bamini Jayabalasingham, Matthias Marti, Pierre-Yves Mantel, Marcus C. S. Lee

المصدر: Cell Host & Microbe. 18(3):371-381

مصطلحات موضوعية: Drug, Cancer Research, media_common.quotation_subject, Plasmodium falciparum, Biology, Microbiology, Article, Mass Spectrometry, Virology, Immunology and Microbiology(all), parasitic diseases, medicine, Gametocyte, Molecular Biology, media_common, chemistry.chemical_classification, Drug discovery, Lipid metabolism, biology.organism_classification, Lipid Metabolism, Lipids, Microvesicles, 3. Good health, Red blood cell, Enzyme, medicine.anatomical_structure, chemistry, Biochemistry, Parasitology, lipids (amino acids, peptides, and proteins), Chromatography, Liquid

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::870838db86a206e57d854019ec38f1bdTest

المؤلفون: Kim C. Heimsch, Gavreel Kalantarov, Marcus C. S. Lee, Sachel Mok, Michal Kuderjavy, Judith Straimer, Barbara H. Stokes, Audrey R. Odom John, Katja Becker, Ilya Trakht, David A. Fidock, Rachel L. Edwards, Nina F. Gnädig, Audrey Crane

المصدر: PLoS Pathogens
PLoS Pathogens, Vol 16, Iss 4, p e1008482 (2020)

مصطلحات موضوعية: Plasmodium, medicine.medical_treatment, Cell Membranes, Mutant, Drug Resistance, Protozoan Proteins, Vacuole, Endoplasmic Reticulum, Biochemistry, Parasite hosting, Biology (General), Malaria, Falciparum, Energy-Producing Organelles, 0303 health sciences, Secretory Pathway, biology, 030302 biochemistry & molecular biology, Artemisinins, Mitochondria, Cell biology, Cell Processes, Cellular Structures and Organelles, Research Article, QH301-705.5, Plasmodium falciparum, Immunology, Dihydroartemisinin, Bioenergetics, Microbiology, Antimalarials, 03 medical and health sciences, Virology, DNA-binding proteins, Parasite Groups, parasitic diseases, Genetics, medicine, Humans, Trophozoites, Hemoglobin, Vesicles, Molecular Biology, 030304 developmental biology, Endoplasmic reticulum, Biology and Life Sciences, Proteins, Membrane Proteins, Cell Biology, RC581-607, biology.organism_classification, Membrane protein, Mutation, Parasitology, Rab, Immunologic diseases. Allergy, Apicomplexa

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::043e5f5e56ae46495765fd5c64668dd4Test
https://doi.org/10.1371/journal.ppat.1008482Test

المؤلفون: Philip D. Gregory, Jocelynn R. Pearl, Edward J. Rebar, Lei Zhang, Manuel Llinás, David A. Fidock, Marcus C. S. Lee, Fyodor D. Urnov, Judith Straimer, Andrew H. Lee, April E. Williams, Bryan Zeitler

المصدر: Nature Methods. 9:993-998

مصطلحات موضوعية: Molecular Sequence Data, Plasmodium falciparum, Drug Resistance, Locus (genetics), Biology, Protein Engineering, Biochemistry, Genome, Article, Genome editing, parasitic diseases, Molecular Biology, Gene, Alleles, Genetics, Zinc finger, Base Sequence, Point mutation, Chloroquine, Zinc Fingers, Cell Biology, Endonucleases, biology.organism_classification, Zinc finger nuclease, Genome, Protozoan, Biotechnology

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::943e45534d08a65c009f42d9bfe5a35bTest
https://doi.org/10.1038/nmeth.2143Test

المؤلفون: Marcus C. S. Lee, Mariana Dorrington, Leslie Kung, Elizabeth A. Miller, Silvere Pagant

المصدر: Molecular Biology of the Cell. 18:3398-3413

مصطلحات موضوعية: Cytoplasm, Protein Folding, Saccharomyces cerevisiae Proteins, Recombinant Fusion Proteins, Amino Acid Motifs, Saccharomyces cerevisiae, Protein Sorting Signals, Endoplasmic-reticulum-associated protein degradation, Biology, Endoplasmic Reticulum, Molecular Biology, COPII, Secretory pathway, Endoplasmic reticulum, Vesicle, Membrane Proteins, ER retention, Articles, Cell Biology, HSP40 Heat-Shock Proteins, Transport protein, Cell biology, Protein Transport, Mutation, Ubiquitin-Conjugating Enzymes, ATP-Binding Cassette Transporters, Mutant Proteins, COP-Coated Vesicles, Protein Processing, Post-Translational, Biogenesis, Molecular Chaperones

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7a7284b429524b29be5ee188bdf5f0bTest
https://doi.org/10.1091/mbc.e07-01-0046Test