المؤلفون: Patrick G. Needham, Adam R Wetzel, Jennifer L. Goeckeler-Fried, Casey Zhang, Zhihao Sun, Carol A. Bertrand, Jeffrey L. Brodsky

المصدر: Biochem J

مصطلحات موضوعية: biology, Protein family, Chemistry, Endoplasmic reticulum, Cell Biology, Endoplasmic Reticulum-Associated Degradation, Saccharomyces cerevisiae, Endoplasmic-reticulum-associated protein degradation, Biochemistry, Models, Biological, Antiporters, Article, Cell biology, Protein structure, HEK293 Cells, Membrane protein, Protein Domains, Sulfate Transporters, Chaperone (protein), biology.protein, Humans, HSP70 Heat-Shock Proteins, Molecular Biology, Secretory pathway, Ion channel

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6870086315364a43ee3817d2c2a7f964Test
https://pubmed.ncbi.nlm.nih.gov/34821356Test

المؤلفون: Annette N. Chiang, Disha Joshi, Peter Wipf, Mads B. Larsen, Raymond A. Frizzell, Jeffrey L. Brodsky, Clare Hill, Jennifer L. Goeckeler-Fried, Rajiah Aldrin Denny, Eric J. Sorscher

المصدر: Bioorg Med Chem Lett

مصطلحات موضوعية: Protein Folding, Ubiquitin-activating enzyme, Clinical Biochemistry, Pharmaceutical Science, Cystic Fibrosis Transmembrane Conductance Regulator, Endoplasmic-reticulum-associated protein degradation, Protein degradation, Biochemistry, Benzoates, Article, Structure-Activity Relationship, Ubiquitin, Drug Discovery, Humans, Furans, Molecular Biology, Integral membrane protein, biology, Dose-Response Relationship, Drug, Molecular Structure, Chemistry, Organic Chemistry, Ubiquitination, Cystic fibrosis transmembrane conductance regulator, Protein ubiquitination, Cell biology, biology.protein, Molecular Medicine, Pyrazoles, Protein folding

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9acacfc386f55a26c851fd71b6ecd340Test
https://pubmed.ncbi.nlm.nih.gov/34246753Test

المؤلفون: Carly S. Mazzone, Antonio Dominguez-Meijide, Jeffrey L. Brodsky, Mary Liang, Tiago F. Outeiro, Annette N. Chiang, David Newhouse, Peter Wipf, Nathan M. Kendsersky, Megan E. Yates, Patrick G. Needham, Caterina Masaracchia, Alexandra Manos-Turvey, Jennifer L. Goeckeler-Fried

المصدر: Bioorganic & Medicinal Chemistry. 27:79-91

مصطلحات موضوعية: Protein Folding, Clinical Biochemistry, Mutant, Cystic Fibrosis Transmembrane Conductance Regulator, Enzyme Activators, Pharmaceutical Science, Pyrimidinones, Saccharomyces cerevisiae, Protein aggregation, 01 natural sciences, Biochemistry, Article, Structure-Activity Relationship, Cell Line, Tumor, Cellular stress response, Drug Discovery, Humans, HSP70 Heat-Shock Proteins, Molecular Biology, Adenosine Triphosphatases, Molecular Structure, biology, 010405 organic chemistry, Activator (genetics), Chemistry, Organic Chemistry, HEK 293 cells, Esters, Cystic fibrosis transmembrane conductance regulator, 3. Good health, 0104 chemical sciences, Hsp70, Cell biology, 010404 medicinal & biomolecular chemistry, HEK293 Cells, Proteostasis, alpha-Synuclein, biology.protein, Molecular Medicine, Protein Multimerization

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6e5c63d4a71c5b638613d360a3ee103Test
https://doi.org/10.1016/j.bmc.2018.11.011Test

المؤلفون: W. Joon Chung, Adam B. Keeton, Allan M. Weissman, Zackery E. Plyler, E. Lucile White, Jeffrey L. Brodsky, Marina Mazur, Viktória Havasi, Eric J. Sorscher, Lynn Rasmussen, Gary A. Piazza, Jennifer L. Goeckeler-Fried, Jeong S. Hong, Annette N. Chiang, R. Aldrin Denny, Steven M. Rowe

المصدر: PLoS ONE, Vol 11, Iss 10, p e0163615 (2016)
PLoS ONE

مصطلحات موضوعية: 0301 basic medicine, Protein Folding, Cystic Fibrosis, Pulmonology, Cell Membranes, Cystic Fibrosis Transmembrane Conductance Regulator, lcsh:Medicine, Bioinformatics, Endoplasmic Reticulum, Hydroxamic Acids, Cystic fibrosis, Benzoates, Biochemistry, Epithelium, Mutant protein, Animal Cells, Medicine and Health Sciences, lcsh:Science, Cells, Cultured, Vorinostat, Multidisciplinary, biology, Organic Compounds, Messenger RNA, Small molecule, Cystic fibrosis transmembrane conductance regulator, 3. Good health, Cell biology, Nucleic acids, Chemistry, Genetic Diseases, High-content screening, Physical Sciences, Cell lines, Cellular Types, Anatomy, Cellular Structures and Organelles, Biological cultures, Research Article, Biotechnology, Library Screening, Research and Analysis Methods, Small Molecule Libraries, 03 medical and health sciences, Autosomal Recessive Diseases, medicine, Humans, RNA, Messenger, Furans, Molecular Biology Techniques, Molecular Biology, Alleles, Clinical Genetics, Molecular Biology Assays and Analysis Techniques, Endoplasmic reticulum, Organic Chemistry, HEK 293 cells, lcsh:R, Wild type, Ubiquitination, Chemical Compounds, Biology and Life Sciences, Epithelial Cells, Cell Biology, Cell Cultures, medicine.disease, Fibrosis, High-Throughput Screening Assays, Protein Structure, Tertiary, 030104 developmental biology, HEK293 Cells, Biological Tissue, Microscopy, Fluorescence, Small Molecules, biology.protein, Pyrazoles, RNA, lcsh:Q, Gene Deletion, HeLa Cells, Developmental Biology

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::548cb6f2b3cb88d56f75f466b19a5a57Test
http://europepmc.org/articles/PMC5061379?pdf=renderTest

المؤلفون: Christina M. Camara, Anita Thakur, Wissam Mansour, Urszula Nowicka, Frank Parlati, Daoning Zhang, Raymond J. Deshaies, Susan Krueger, Carlos A. Castañeda, Steven M. Bonn, Ortal Hayat, Michael H. Glickman, Jeffrey L. Brodsky, Mark A. Nakasone, Jennifer L. Goeckeler-Fried, Olivier Walker, Tsui-Fen Chou, Timothy A. Lewis, David Fushman

المساهمون: Biophysics of complex systems, Institut des Sciences Analytiques (ISA), Institut de Chimie du CNRS (INC)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS), Ctr Biomol Struct & Org, University of Maryland [College Park], University of Maryland System-University of Maryland System, Ctr Neutron Res, National Institute of Standards and Technology [Gaithersburg] (NIST), Department of Biology - Institute of Technology, Technion - Israel Institute of Technology [Haifa], We thank George H. Lorimer and Arnon Henn for access to their fluorimeters, Ananya Majumdar for help with setting up triple-resonance NMR experiments, Rajesh Singh for the Rub1 sample, Allan Weissman for RCC4 cells, and Konstantin Berlin for useful discussions. The project has been funded in part from the NCI Initiative for Chemical Genetics, NIH, under contract no. N01-CO-12400 to Stuart L. Schreiber, by NIH grants GM065334 to D.F. and GM095755 to D.F. and M.H.G., ISF grant 909-14 to M.H.G., and by NIH grants GM075061 and DK079307 and by Cystic Fibrosis Foundation Therapeutics grant BRODSK13XXO to J.L.B., and a Fulbright postdoctoral fellowship to M.A.N., and utilized NMR instrumentation supported in part by NSF grant DBI1040158 and neutron-scattering facilities supported in part by the NSF under agreement no. DMR-0944772. R.J.D. is a founder and shareholder of Cleave Biosciences, which is developing drugs that target the ubiquitin system., Technion-Israel Institute of Technology

المصدر: Structure
Structure, Elsevier (Cell Press), 2017, 25 (12), pp.1839-1855.e11. ⟨10.1016/j.str.2017.10.007⟩

مصطلحات موضوعية: 0301 basic medicine, Proteasome Endopeptidase Complex, Sulfanilic Acids, Saccharomyces cerevisiae, Ubiquitin-conjugating enzyme, 010402 general chemistry, 01 natural sciences, Article, Cell Line, Deubiquitinating enzyme, 03 medical and health sciences, Ubiquitin, [CHIM.ANAL]Chemical Sciences/Analytical chemistry, Structural Biology, medicine, Humans, Ubiquitins, Molecular Biology, ComputingMilieux_MISCELLANEOUS, Binding Sites, biology, Small molecule, 0104 chemical sciences, 3. Good health, Ubiquitin ligase, Cell biology, Molecular Docking Simulation, 030104 developmental biology, Proteasome, Biochemistry, Quinolines, biology.protein, Proteasome inhibitor, HeLa Cells, Protein Binding, medicine.drug, Deubiquitination

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dfec4eed37788062c40d159ac6f34b69Test
https://doi.org/10.1016/j.str.2017.10.007Test