Lyophilized Maqui (Aristotelia chilensis) Berry Induces Browning in the Subcutaneous White Adipose Tissue and Ameliorates the Insulin Resistance in High Fat Diet-Induced Obese Mice
| العنوان: | Lyophilized Maqui (Aristotelia chilensis) Berry Induces Browning in the Subcutaneous White Adipose Tissue and Ameliorates the Insulin Resistance in High Fat Diet-Induced Obese Mice |
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| المؤلفون: | Hèctor Sanz-Lamora, Diego Haro, Pedro F. Marrero, Antoni Femenias, Viviana Sandoval, Rosa M. Lamuela-Raventós, Juan Manuel Castagnini, Úrsula Martínez-Garza, Joana Relat, Paola Quifer-Rada |
| المساهمون: | Sandoval V., Femenias A., Martinez-Garza U., Sanz-Lamora H., Castagnini J.M., Quifer-Rada P., Lamuela-Raventos R.M., Marrero P.F., Haro D., Relat J. |
| المصدر: | Antioxidants Volume 8 Issue 9 Dipòsit Digital de la UB Universidad de Barcelona Antioxidants, Vol 8, Iss 9, p 360 (2019) Repositorio Abierto de la UdL Universitad de Lleida Sandoval, Viviana Femenias, Antoni Martínez-Garza, Úrsula Sanz-Lamora, Héctor Castagnini, Juan Manuel Quifer-Rada, Paola Lamuela-Raventós, Rosa Maria Marrero, Pedro F. Haro, Diego Relat, Joana 2019 Lyophilized maqui (Aristotelia chilensis) berry induces browning in the subcutaneous white adipose tissue and ameliorates the insulin resistance in high fat diet-induced obese mice Antioxidants r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau instname Recercat. Dipósit de la Recerca de Catalunya RODERIC. Repositorio Institucional de la Universitat de Valéncia |
| بيانات النشر: | Multidisciplinary Digital Publishing Institute, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | 0301 basic medicine, Anthocyanin, FGF21, Physiology, medicine.medical_treatment, Clinical Biochemistry, White adipose tissue, Biochemistry, Maqui berry, Anthocyanins, 0302 clinical medicine, maqui berry, biology, Chemistry, anthocyanins, High-fat diet, high-fat diet, Lipogenesis, Obesitat, medicine.medical_specialty, Ratolins (Animals de laboratori), 030209 endocrinology & metabolism, fibroblast growth factor 21, carbohydrate-responsive element binding protein b, Article, 03 medical and health sciences, Aristotelia chilensis, Insulin resistance, white adipose tissue, Internal medicine, medicine, Obesity, Carbohydrate-responsive element-binding protein, Molecular Biology, browning, delphinidin, Insulin, lcsh:RM1-950, Adipose tissues, Cell Biology, biology.organism_classification, medicine.disease, Teixit adipós, 030104 developmental biology, Endocrinology, lcsh:Therapeutics. Pharmacology, Mice (Laboratory animals), Aliments, Thermogenesis |
| الوصف: | Maqui (Aristotelia Chilensis) berry features a unique profile of anthocyanidins that includes high amounts of delphinidin-3-O-sambubioside-5-O-glucoside and delphinidin-3-O-sambubioside and has shown positive effects on fasting glucose and insulin levels in humans and murine models of type 2 diabetes and obesity. The molecular mechanisms underlying the impact of maqui on the onset and development of the obese phenotype and insulin resistance was investigated in high fat diet-induced obese mice supplemented with a lyophilized maqui berry. Maqui-dietary supplemented animals showed better insulin response and decreased weight gain but also a differential expression of genes involved in de novo lipogenesis, fatty acid oxidation, multilocular lipid droplet formation and thermogenesis in subcutaneous white adipose tissue (scWAT). These changes correlated with an increased expression of the carbohydrate response element binding protein b (Chrebpb), the sterol regulatory binding protein 1c (Srebp1c) and Cellular repressor of adenovirus early region 1A&ndash stimulated genes 1 (Creg1) and an improvement in the fibroblast growth factor 21 (FGF21) signaling. Our evidence suggests that maqui dietary supplementation activates the induction of fuel storage and thermogenesis characteristic of a brown-like phenotype in scWAT and counteracts the unhealthy metabolic impact of an HFD. This induction constitutes a putative strategy to prevent/treat diet-induced obesity and its associated comorbidities. |
| وصف الملف: | application/pdf; ELETTRONICO |
| اللغة: | English |
| تدمد: | 2076-3921 |
| DOI: | 10.3390/antiox8090360 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::baf24ec4621fbf88ba7896962bf769c8Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....baf24ec4621fbf88ba7896962bf769c8 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20763921 |
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| DOI: | 10.3390/antiox8090360 |