المؤلفون: Gielen, Marc, Barilone, Nathalie, Corringer, Pierre-Jean

المساهمون: Récepteurs Canaux - Channel Receptors, Institut Pasteur Paris (IP)-Centre National de la Recherche Scientifique (CNRS), Sorbonne Université (SU), Financial support by the Fondation de la Recherche Médicale (grant “Équipe FRM” DEQ20140329497 to P.-J.C.) and the European Commission Research Executive Agency (Marie Sklodowska-Curie Action, Individual Fellowship 659371 to M.G., ERC Advanced Grant GA788974 Dynacotine to P.-J.C.). M.G. is grateful to the Fondation Bettencourt Schueller for their support., European Project: 659371,H2020,H2020-MSCA-IF-2014,nAChR PAM-to-gate(2015), European Project: 788974,H2020

المصدر: ISSN: 2041-1723.

مصطلحات موضوعية: MESH: Animals, MESH: Computer Simulation, MESH: Protein Conformation, MESH: Protein Subunits, MESH: Receptors, GABA-A, MESH: Synaptic Transmission, MESH: Xenopus laevis, MESH: Ion Channels, MESH: Ion Transport, MESH: Kinetics, MESH: Models, Molecular, MESH: Molecular Conformation, MESH: Mutation, MESH: Nervous System, MESH: Oocytes, [SDV]Life Sciences [q-bio]

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/33097732; info:eu-repo/grantAgreement//659371/EU/Gating mechanism and pharmacological modulation of nicotinic acetylcholine receptors/nAChR PAM-to-gate; info:eu-repo/grantAgreement//788974/EU/Signal transduction and allosteric modulation of nicotinic acetylcholine receptors:from ion channel electrophysiology to atomic 3D structures/Dynacotine; pasteur-03088067; https://pasteur.hal.science/pasteur-03088067Test; https://pasteur.hal.science/pasteur-03088067/documentTest; https://pasteur.hal.science/pasteur-03088067/file/Gielen.%202020.pdfTest; PUBMED: 33097732; PUBMEDCENTRAL: PMC7585415

الإتاحة: https://doi.org/10.1038/s41467-020-19218-6Test
https://pasteur.hal.science/pasteur-03088067Test
https://pasteur.hal.science/pasteur-03088067/documentTest
https://pasteur.hal.science/pasteur-03088067/file/Gielen.%202020.pdfTest

المؤلفون: Arduino, Daniela, Wettmarshausen, Jennifer, Vais, Horia, Navas-Navarro, Paloma, Cheng, Yiming, Leimpek, Anja, Ma, Zhongming, Delrio-Lorenzo, Alba, Giordano, Andrea, Garcia-Perez, Cecilia, Médard, Guillaume, Kuster, Bernhard, García-Sancho, Javier, Mokranjac, Dejana, Foskett, J Kevin, Alonso, M Teresa, Perocchi, Fabiana, Foskett, J. Kevin, Alonso, M. Teresa

المساهمون: Approches génétiques intégrées et nouvelles thérapies pour les maladies rares (INTEGRARE), École Pratique des Hautes Études (EPHE), Université Paris Sciences et Lettres (PSL)-Université Paris Sciences et Lettres (PSL)-Université d'Évry-Val-d'Essonne (UEVE)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Généthon

المصدر: ISSN: 1097-2765.

مصطلحات موضوعية: MCU, bioenergetics, calcium, calcium signaling, drug discovery, drug screening, high-throughput screening, mitochondria, mitochondrial calcium uniporter, MESH: Aequorin, MESH: Animals, MESH: High-Throughput Screening Assays, MESH: Humans, MESH: Kinetics, MESH: Lactic Acid, MESH: Mannitol, MESH: Membrane Potentials, MESH: Mice, Transgenic, MESH: Mitochondria, MESH: Mitoxantrone, MESH: Models, Molecular, MESH: Calcium, MESH: Molecular Structure, MESH: Saccharomyces cerevisiae, MESH: Structure-Activity Relationship, MESH: Sucrose, MESH: Xenopus laevis, MESH: Calcium Channel Blockers

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/28820965; hal-03157659; https://hal.science/hal-03157659Test; PUBMED: 28820965; PUBMEDCENTRAL: PMC5825229

الإتاحة: https://doi.org/10.1016/j.molcel.2017.07.019Test
https://hal.science/hal-03157659Test

المؤلفون: Fourati, Zaineb, Ruza, Reinis Reinholds, Laverty, Duncan, Drège, Emmanuelle, Delarue, Sandrine, Joseph, Delphine, Koehl, Patrice, Smart, Trevor, Delarue, Marc

المساهمون: Dynamique structurale des Macromolécules / Structural Dynamics of Macromolecules, Institut Pasteur Paris (IP)-Centre National de la Recherche Scientifique (CNRS), University College of London London (UCL), Biomolécules : Conception, Isolement, Synthèse (BioCIS), Université Paris-Sud - Paris 11 (UP11)-Université de Cergy Pontoise (UCP), Université Paris-Seine-Université Paris-Seine-Institut de Chimie - CNRS Chimie (INC-CNRS)-Centre National de la Recherche Scientifique (CNRS), University of California Davis (UC Davis), University of California (UC), This work was supported by the 'Agence Nationale de la Recherche' grant “Pentagate” (to M. D. and D. J.). The authors declare that they have no conflicts of interest with the contents of this article., We are indebted to Synchrotron SOLEIL (Saint Aubin) and the European Synchrotron Radiation Facility (ESRF) (Grenoble, France) for excellent beamline facilities. We thank Frederic Poitevin for the optimized alignment of GLIC and GABAAR sequences., ANR-13-BSV8-0020,Pentagate,Mécanismes d'activation et de désensibilisation d'un récepteur-canal pentamérique(2013)

المصدر: ISSN: 0021-9258.

مصطلحات موضوعية: anesthesia, barbiturates, crystallography, electrophysiology, ligand-gated ion channels, membrane protein, structural biology, x-ray crystallography, MESH: Animals, MESH: Bacterial Proteins, MESH: Barbiturates, MESH: Binding Sites, MESH: Crystallography, X-Ray, MESH: Cyanobacteria, MESH: Ion Channels, MESH: Models, Molecular, MESH: Protein Structure, Quaternary, MESH: Xenopus laevis, [SDV.BBM.BS]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Structural Biology [q-bio.BM]

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/27986812; pasteur-02174609; https://pasteur.hal.science/pasteur-02174609Test; PUBMED: 27986812; PUBMEDCENTRAL: PMC5290934

الإتاحة: https://doi.org/10.1074/jbc.M116.766964Test
https://pasteur.hal.science/pasteur-02174609Test

المؤلفون: Rapetti-Mauss, Raphael, Lacoste, Caroline, Picard, Veronique, Guitton, Corinne, Lombard, Elise, Loosveld, Marie, Nivaggioni, Vanessa, Dasilva, Nathalie, Salgado, David, Desvignes, Jean-Pierre, Béroud, Christophe, Viout, Patrick, Bernard, Monique, Soriani, Olivier, Vinti, Henri, Lacroze, Valérie, Feneant-Thibault, Madeleine, Thuret, Isabelle, Guizouarn, Hélène, Badens, Catherine

المساهمون: Institut de Biologie Valrose (IBV), Université Nice Sophia Antipolis (1965 - 2019) (UNS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Côte d'Azur (UniCA)

المصدر: ISSN: 0006-4971.

مصطلحات موضوعية: MESH: Adult, MESH: Amino Acid Sequence, MESH: Hydrops Fetalis, MESH: In Vitro Techniques, MESH: Infant, Newborn, MESH: Intermediate-Conductance Calcium-Activated Potassium Channels, MESH: Male, MESH: Models, Molecular, MESH: Molecular Sequence Data, MESH: Mutant Proteins, MESH: Mutation, Missense, MESH: Anemia, Hemolytic, Congenital, MESH: Oocytes, MESH: Osmotic Fragility, MESH: Patch-Clamp Techniques, MESH: Pedigree, MESH: Pregnancy, MESH: Recombinant Proteins, MESH: Sequence Homology, Amino Acid, MESH: Xenopus laevis, MESH: Animals, MESH: Child, Preschool, MESH: Erythrocytes

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/26148990; hal-01252935; https://hal.science/hal-01252935Test; PUBMED: 26148990

الإتاحة: https://hal.science/hal-01252935Test

المؤلفون: Daujat, Sylvain, Weiss, Thomas, Mohn, Fabio, Lange, Ulrike C, Ziegler-Birling, Céline, Zeissler, Ulrike, Lappe, Michael, Schübeler, Dirk, Torres-Padilla, Maria-Elena, Schneider, Robert

المساهمون: Max Planck Institute of Immunobiology, Friedrich Miescher Institute for Biomedical Research (FMI), Novartis Research Foundation, Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), Université de Strasbourg (UNISTRA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Max Planck Institute for Molecular Genetics (MPIMG), Max-Planck-Gesellschaft

المصدر: ISSN: 1545-9993.

مصطلحات موضوعية: MESH: Animals, MESH: Cell Line, MESH: Methyltransferases, MESH: Mice, MESH: Models, Molecular, MESH: Molecular Sequence Data, MESH: Nucleic Acid Conformation, MESH: Nucleosomes, MESH: Protein Conformation, MESH: Repressor Proteins, MESH: Xenopus laevis, MESH: DNA, MESH: DNA Methylation, MESH: Embryo, Mammalian, MESH: Epigenesis, Genetic, MESH: Heterochromatin, MESH: Histones, MESH: Humans, MESH: Lysine

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/19561610; inserm-00420391; https://inserm.hal.science/inserm-00420391Test; PUBMED: 19561610

الإتاحة: https://doi.org/10.1038/nsmb.1629Test
https://inserm.hal.science/inserm-00420391Test

المؤلفون: Srairi-Abid, Najet, Shahbazzadeh, Delavar, Chatti, Imen, Mlayah-Bellalouna, Saoussen, Mejdoub, Hafedh, Borchani, Lamia, Benkhalifa, Rym, Akbari, Abolfazl, El Ayeb, Mohamed

المساهمون: Laboratoire des Venins et Toxines, Institut Pasteur de Tunis, Institut Pasteur de Tunis, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP), Medical Biotechnology Group, Venom and Toxin Lab, Institut Pasteur d'Iran, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP)-Biotechnology Research Center, USCR Séquenceur de Protéines, Faculté des Sciences de Sfax (FSS), Université de Sfax - University of Sfax-Université de Sfax - University of Sfax, Razi Vaccine & Serum Research Institute, This research was supported by MRST and the International Network of the Pasteur Institutes.

المصدر: ISSN: 1742-464X.

مصطلحات موضوعية: scorpion toxin, structure-function relationships, Hemiscorpius lepturus, hemitoxin, K+ channel, MESH: Amino Acid Sequence, MESH: Animals, MESH: Patch-Clamp Techniques, MESH: Potassium Channel Blockers, MESH: Rats, MESH: Scorpion Venoms, MESH: Sequence Homology, Amino Acid, MESH: Structure-Activity Relationship, MESH: Xenopus laevis, MESH: Disulfides, MESH: Elapid Venoms, MESH: Iran, MESH: Male, MESH: Mice, MESH: Models, Molecular, MESH: Molecular Sequence Data, MESH: Oocytes, [SDV]Life Sciences [q-bio]

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/18699777; pasteur-01375219; https://riip.hal.science/pasteur-01375219Test; https://riip.hal.science/pasteur-01375219/documentTest; https://riip.hal.science/pasteur-01375219/file/Hemitoxin%20%281%29.pdfTest; PUBMED: 18699777

الإتاحة: https://doi.org/10.1111/j.1742-4658.2008.06607.xTest
https://riip.hal.science/pasteur-01375219Test
https://riip.hal.science/pasteur-01375219/documentTest
https://riip.hal.science/pasteur-01375219/file/Hemitoxin%20%281%29.pdfTest

المؤلفون: Rees, Mark I, Harvey, Kirsten, Pearce, Brian R, Chung, Seo-Kyung, Duguid, Ian C, Thomas, Philip, Beatty, Sarah, Graham, Gail E, Armstrong, Linlea, Shiang, Rita, Abbott, Kim J, Zuberi, Sameer M, Stephenson, John B P, Owen, Michael J, Tijssen, Marina A J, Van Den Maagdenberg, Arn M J M, Smart, Trevor G, Supplisson, Stéphane, Harvey, Robert J

المساهمون: Laboratoire de Neurobiologie (UMR 8544) (NEURO), École normale supérieure - Paris (ENS Paris), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)

المصدر: ISSN: 1061-4036.

مصطلحات موضوعية: GlyT2, transporter, hyperekplexia, glycine, mutagenesis, neuromuscular disorder, pre synaptic, MESH: Amino Acid Sequence, MESH: Amino Acid Substitution, MESH: Molecular Sequence Data, MESH: Mutation, MESH: Oocytes, MESH: Presynaptic Terminals, MESH: Protein Structure, Tertiary, MESH: Recombinant Fusion Proteins, MESH: Startle Reaction, MESH: Transfection, MESH: Xenopus laevis, MESH: Animals, MESH: Cell Line, MESH: Female, MESH: Glycine Plasma Membrane Transport Proteins, MESH: Humans, MESH: Infant, Newborn, MESH: Male, MESH: Models, Molecular, [SDV.NEU.NB]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/16751771; hal-00145150; https://hal.archives-ouvertes.fr/hal-00145150Test; PUBMED: 16751771

الإتاحة: https://doi.org/10.1038/ng1814Test
https://hal.archives-ouvertes.fr/hal-00145150Test

المؤلفون: Baltzinger, Mireille, Ori, Michela, Pasqualetti, Massimo, Nardi, Irma, Rijli, Filippo M

المساهمون: Institut de génétique et biologie moléculaire et cellulaire (IGBMC), Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Louis Pasteur - Strasbourg I

المصدر: ISSN: 1058-8388.

مصطلحات موضوعية: MESH: Animals, MESH: Body Patterning, MESH: Sequence Analysis, DNA, MESH: Transcription Factors, MESH: Xenopus Proteins, MESH: Xenopus laevis, MESH: Branchial Region, MESH: Cell Differentiation, MESH: Cloning, Molecular, MESH: DNA Primers, MESH: Gene Expression Regulation, Developmental, MESH: Homeodomain Proteins, MESH: In Situ Hybridization, MESH: Neural Crest, [SDV.BBM.BM]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Molecular biology

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/16222714; hal-00187433; https://hal.archives-ouvertes.fr/hal-00187433Test; PUBMED: 16222714

الإتاحة: https://doi.org/10.1002/dvdy.20567Test
https://hal.archives-ouvertes.fr/hal-00187433Test

المؤلفون: Cosson, Bertrand, Braun, Frederique, Paillard, Luc, Blackshear, Perry, Beverley Osborne, H.

المساهمون: Mer et santé (MS), Station biologique de Roscoff Roscoff (SBR), Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS), Recherches en cancérologie, Université de Nantes (UN)-IFR26-Institut National de la Santé et de la Recherche Médicale (INSERM), Université européenne de Bretagne - European University of Brittany (UEB), Institut de Génétique et Développement de Rennes (IGDR), Université de Rennes (UR)-Centre National de la Recherche Scientifique (CNRS)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Duke University Durham

المصدر: ISSN: 0248-4900.

مصطلحات موضوعية: MESH: Amino Acid Sequence, MESH: Animals, MESH: Xenopus laevis, MESH: Cloning, Molecular, MESH: Molecular Sequence Data, MESH: Phylogeny, MESH: Poly(A)-Binding Proteins, MESH: RNA, Messenger, MESH: RNA-Binding Proteins, MESH: Sequence Alignment, MESH: Xenopus Proteins, [SDV.BBM.BM]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Molecular biology

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/15380618; hal-00982685; https://univ-rennes.hal.science/hal-00982685Test; PUBMED: 15380618

الإتاحة: https://doi.org/10.1016/j.biolcel.2004.04.006Test
https://univ-rennes.hal.science/hal-00982685Test

المؤلفون: Gautier-Courteille, Carole, Le Clainche, Christophe, Barreau, Carine, Audic, Yann, Graindorge, Antoine, Maniey, Dominique, Osborne, Howard Beverley, Paillard, Luc

المساهمون: Institut de Génétique et Développement de Rennes (IGDR), Université de Rennes (UR)-Centre National de la Recherche Scientifique (CNRS)

المصدر: ISSN: 0950-1991.

مصطلحات موضوعية: MESH: Animals, MESH: Cloning, Molecular, MESH: Embryo, Nonmammalian, MESH: Gene Expression Regulation, Developmental, MESH: Poly A, MESH: RNA-Binding Proteins, MESH: Somites, MESH: Xenopus Proteins, MESH: Xenopus laevis, [SDV.BDD]Life Sciences [q-bio]/Development Biology

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/15548579; inserm-00292940; https://www.hal.inserm.fr/inserm-00292940Test; https://www.hal.inserm.fr/inserm-00292940/documentTest; https://www.hal.inserm.fr/inserm-00292940/file/Development_2004.pdfTest; PUBMED: 15548579

الإتاحة: https://doi.org/10.1242/dev.01528Test
https://www.hal.inserm.fr/inserm-00292940Test
https://www.hal.inserm.fr/inserm-00292940/documentTest
https://www.hal.inserm.fr/inserm-00292940/file/Development_2004.pdfTest