iabetic Encephalopathy Affecting Mitochondria and Axonal Transport Proteins
| العنوان: | iabetic Encephalopathy Affecting Mitochondria and Axonal Transport Proteins |
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| المؤلفون: | Mehrdad Roghani, Torandokht Baluchnejad Mojarad, Arezo Nahavandi, Maryam Eslami Gharaati |
| المصدر: | Basic and Clinical Neuroscience, Vol 11, Iss 6, Pp 781-794 (2020) Basic and Clinical Neuroscience |
| بيانات النشر: | Negah Scientific Publisher, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | diabetes mellitus type 1, 0301 basic medicine, medicine.medical_specialty, medicine.medical_treatment, Blood sugar, Mitochondrion, Hippocampal formation, lcsh:RC321-571, kif5b protein, 03 medical and health sciences, Cellular and Molecular Neuroscience, 0302 clinical medicine, Internal medicine, Diabetes mellitus, medicine, lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry, Cognitive deficit, dynein, Insulin, medicine.disease, Streptozotocin, mitochondria, 030104 developmental biology, Endocrinology, Axoplasmic transport, Neurology (clinical), axonal transport, medicine.symptom, mitochondrial encephalopathy, 030217 neurology & neurosurgery, Research Paper, medicine.drug |
| الوصف: | Introduction: Diabetic encephalopathy is described as any cognitive and memory impairments associated with hippocampal degenerative changes, including the neurodegenerative process and decreased number of living cells. Mitochondrial diabetes (MD) appears following activation of mutant mitochondrial DNA and is a combination of diabetes and cognitive deficit. In this research, we showed the correlation of diabetic encephalopathy, dysfunctional mitochondria, and changes in the expression of axonal transport proteins (KIF5b, Dynein). Methods: Twenty-four male Wistar rats were divided into three groups: (n=8 in each group):1. Control + saline; 2. Diabetic, and 3. Diabetic + insulin. Before starting the experiments, the animals with blood sugar lower than 150 mg/dL entered the study. Diabetes induction was carried out by Intraperitoneal (IP) Streptozotocin (STZ) administration. Fasting Blood Sugar (FBS) and body weight was checked after the first week and at the end of the eighth week. Then, behavioral studies (elevated plus maze, Y-maze, and passive avoidance learning) were performed. After behavioral studies, blood samples were taken to measure serum insulin level and HgbA1c. Next, fresh hippocampal tissue was collected. Gene expression of motor proteins was assessed by real-time PCR and mitochondrial membrane potential by rhodamine123. Results: Our results showed the impairment of HgbA1c, serum insulin, FBS, and weight in the diabetic group (P |
| تدمد: | 2008-126X 2228-7442 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aeee1855ab43ee4b00e0ed06e721a2f0Test https://doi.org/10.32598/bcn.11.6.1657.1Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....aeee1855ab43ee4b00e0ed06e721a2f0 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 2008126X 22287442 |
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