دورية أكاديمية
Mitochondrial cholesterol accumulation in alcoholic liver disease: Role of ASMase and endoplasmic reticulum stress
| العنوان: | Mitochondrial cholesterol accumulation in alcoholic liver disease: Role of ASMase and endoplasmic reticulum stress |
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| المؤلفون: | Montserrat Marí, Albert Morales, Anna Colell, Carmen García-Ruiz, Jose C. Fernández-Checa |
| المصدر: | Redox Biology, Vol 3, Iss C, Pp 100-108 (2014) |
| بيانات النشر: | Elsevier |
| سنة النشر: | 2014 |
| المجموعة: | Directory of Open Access Journals: DOAJ Articles |
| مصطلحات موضوعية: | Mitochondrial respiratory chain, Mitochondrial cholesterol, Lipotoxicity, ER stress, Mitochondrial GSH, Acid sphingomyelinase, Medicine (General), R5-920, Biology (General), QH301-705.5 |
| الوصف: | Alcoholic liver disease (ALD) is a major cause of chronic liver disease and a growing health concern in theworld. While the pathogenesis of ALD is poorly characterized key players identified in experimental models and patients, such as perturbations in mitochondrial structure and function, selective loss of antioxidant defense and susceptibility to inflammatory cytokines, contribute to ALD progression. Both oxidative stress and mitochondrial dysfunction compromise essential cellular functions and energy generation and hence are important pathogenic mechanisms of ALD. An important process mediating the mitochondrial disruption induced by alcohol intake is the trafficking of cholesterol to mitochondria, mediated by acid sphingomyelinase-induced endoplasmic reticulum stress, which contributes to increased cholesterol synthesis and StARD1upregulation. Mitochondrial cholesterol accumulation not only sensitizes to oxidative stress but it can contribute to the metabolic reprogramming in ALD, manifested by activation of the hypoxia inducible transcription factor 1 and stimulation of glycolysis and lactate secretion. Thus, a better understanding of the mechanisms underlying alcohol-mediated mitochondrial impairment and oxidative stress may lead to the identification of novel treatments for ALD. The present review briefly summarizes current knowledge on the cellular and molecular mechanisms contributing to alcohol-induced mitochondrial dysfunction and cholesterol accumulation and provides insights for potential therapeutic targets in ALD. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 2213-2317 |
| العلاقة: | http://www.sciencedirect.com/science/article/pii/S2213231714001049Test; https://doaj.org/toc/2213-2317Test; https://doaj.org/article/fa13807635bb4911a7daf2c8cb7f7dddTest |
| DOI: | 10.1016/j.redox.2014.09.005 |
| الإتاحة: | https://doi.org/10.1016/j.redox.2014.09.005Test https://doaj.org/article/fa13807635bb4911a7daf2c8cb7f7dddTest |
| رقم الانضمام: | edsbas.1603DDCF |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 22132317 |
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| DOI: | 10.1016/j.redox.2014.09.005 |