المؤلفون: Claudia V Pereira, Sandra R Bacman, Tania Arguello, Ugne Zekonyte, Sion L Williams, David R Edgell, Carlos T Moraes

المصدر: EMBO Molecular Medicine, Vol 10, Iss 9, Pp n/a-n/a (2018)

مصطلحات موضوعية: heteroplasmy, I‐TevI, mitochondrial DNA, mitoTev‐TALE, monomeric, Medicine (General), R5-920, Genetics, QH426-470

العلاقة: https://doi.org/10.15252/emmm.201708084Test; https://doaj.org/toc/1757-4676Test; https://doaj.org/toc/1757-4684Test; https://doaj.org/article/7a381d0d4b6e4d0eb16577d5be175b52Test

الإتاحة: https://doi.org/10.15252/emmm.201708084Test
https://doaj.org/article/7a381d0d4b6e4d0eb16577d5be175b52Test

المؤلفون: Maulik R. Patel, Bryan L. Gitschlag, Claudia V Pereira

المصدر: Critical Reviews in Biochemistry and Molecular Biology. 56:510-525

مصطلحات موضوعية: Genetics, 0303 health sciences, Mitochondrial DNA, 030302 biochemistry & molecular biology, Mutant, Cellular pathways, food and beverages, Mitochondrion, Biology, Heteroplasmy, DNA, Mitochondrial, Biochemistry, Mitochondria, Mtdna mutations, 03 medical and health sciences, Negative selection, Critical threshold, Molecular Biology, 030304 developmental biology

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ccbafa129d4830d6828584956f6e6c37Test
https://doi.org/10.1080/10409238.2021.1934812Test

المؤلفون: Ginger Tomberlin, Jeff Smith, James B. Stewart, Ugne Zekonyte, Claudia V. Pereira, Sandra R. Bacman, Carlos T. Moraes, Derek Jantz, Wendy Shoop

المصدر: Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
Nat Commun

مصطلحات موضوعية: 0301 basic medicine, Mitochondrial DNA, Mitochondrial Diseases, Science, Mutant, Genetic Vectors, Primary Cell Culture, General Physics and Astronomy, Mice, Transgenic, RNA, Transfer, Ala, Double-strand DNA breaks, Biology, medicine.disease_cause, DNA, Mitochondrial, General Biochemistry, Genetics and Molecular Biology, Article, 03 medical and health sciences, Mice, 0302 clinical medicine, Gene therapy, medicine, Animals, Humans, Point Mutation, Gene, Genetics, Gene Editing, Transcription activator-like effector nuclease, Mutation, Multidisciplinary, Molecular medicine, Point mutation, General Chemistry, DNA Restriction Enzymes, Genetic Therapy, Dependovirus, Fibroblasts, Heteroplasmy, Mitochondria, Disease Models, Animal, 030104 developmental biology, Meganuclease, 030217 neurology & neurosurgery, HeLa Cells

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b3f9acba0c101ef2d066a602759ef34Test
https://pubmed.ncbi.nlm.nih.gov/34050192Test

المؤلفون: James B. Stewart, Maria Miranda, Johanna H.K. Kauppila, Nils-Göran Larsson, Sandra R. Bacman, Claudia V. Pereira, Nadee Nissanka, Milena F. Pinto, Sion L. Williams, Carlos T. Moraes

المصدر: Nat Med

مصطلحات موضوعية: 0301 basic medicine, Genetics, Mitochondrial DNA, Mutant, General Medicine, Biology, General Biochemistry, Genetics and Molecular Biology, Heteroplasmy, 03 medical and health sciences, 030104 developmental biology, Mutation (genetic algorithm), Transfer RNA, ComputingMethodologies_DOCUMENTANDTEXTPROCESSING, Base (exponentiation)

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55a41bf9ef962ae35789c8d64a452ff5Test
https://hdl.handle.net/21.11116/0000-000B-4945-6Test

المؤلفون: Sion L. Williams, Carlos T. Moraes, Maria Miranda, Milena F. Pinto, Nadee Nissanka, Johanna H.K. Kauppila, Claudia V. Pereira, James B. Stewart, Nils-Göran Larsson, Sandra R. Bacman

المصدر: Nat Med

مصطلحات موضوعية: 0301 basic medicine, Mitochondrial DNA, Mitochondrial Diseases, Mutant, Oxidative phosphorylation, Biology, Mitochondrion, medicine.disease_cause, DNA, Mitochondrial, General Biochemistry, Genetics and Molecular Biology, Article, Mitochondria, Heart, Oxidative Phosphorylation, 03 medical and health sciences, Mice, Transcription Activator-Like Effector Nucleases, medicine, Animals, Humans, Point Mutation, Muscle, Skeletal, Mutation, Heart, General Medicine, Molecular biology, Phenotype, Heteroplasmy, Mitochondria, Muscle, Disease Models, Animal, 030104 developmental biology, Transfer RNA

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::441d11be9409fc4a5c6e081c006b5dd1Test
https://hdl.handle.net/21.11116/0000-000B-4943-8Test

المؤلفون: David R. Edgell, Sandra R. Bacman, Claudia V. Pereira, Sion L. Williams, Carlos T. Moraes, Tania Arguello, Ugne Zekonyte

المصدر: EMBO Molecular Medicine
EMBO Molecular Medicine, Vol 10, Iss 9, Pp n/a-n/a (2018)

مصطلحات موضوعية: 0301 basic medicine, Medicine (General), Mitochondrial DNA, DNA Repair, Mutant, monomeric, mitochondrial DNA, QH426-470, DNA, Mitochondrial, Viral Proteins, 03 medical and health sciences, chemistry.chemical_compound, R5-920, Transcription Activator-Like Effector Nucleases, Report, Genetics, Humans, heteroplasmy, Molecular Targeted Therapy, Gene, Cells, Cultured, Nuclease, biology, Hydrolysis, Point mutation, Wild type, Endonucleases, MERRF Syndrome, Recombinant Proteins, Heteroplasmy, mitoTev‐TALE, 030104 developmental biology, chemistry, I‐TevI, biology.protein, Molecular Medicine, Genetics, Gene Therapy & Genetic Disease, DNA, Protein Binding, Reports

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e81273749e6a401c3af68d5471cb07dTest
https://doi.org/10.15252/emmm.201708084Test

المؤلفون: Sandra R. Bacman, Carlos T. Moraes, Claudia V. Pereira

المصدر: Mitochondrial Biology and Experimental Therapeutics ISBN: 9783319733432

مصطلحات موضوعية: 0301 basic medicine, Genetics, Transcription activator-like effector nuclease, Mitochondrial DNA, Mitochondrial disease, Point mutation, Haplotype, Mitochondrion, Biology, medicine.disease, Heteroplasmy, 03 medical and health sciences, 030104 developmental biology, 0302 clinical medicine, Genome editing, medicine, 030217 neurology & neurosurgery

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::232136d24436de435c28ac8157b2ae4eTest
https://doi.org/10.1007/978-3-319-73344-9_24Test

المؤلفون: Roberta Brambilla, Mehran Taherian, Dmitry Ivanov, Han Gao, Galina Dvoriantchikova, Milena F. Pinto, Carlos T. Moraes, Stephanie McCarthy, Shreyans Patel, Kenji F. Tanaka, Claudia V. Pereira, Shaffiat Karmally, Pernille M. Madsen

المصدر: Madsen, P M, Pinto, M, Patel, S, McCarthy, S, Gao, H, Taherian, M, Karmally, S, Pereira, C V, Dvoriantchikova, G, Ivanov, D, Tanaka, K F, Moraes, C T & Brambilla, R 2017, ' Mitochondrial DNA double-strand breaks in oligodendrocytes cause demyelination, axonal injury, and CNS inflammation ', Journal of Neuroscience, vol. 37, no. 42, pp. 10185-10199 . https://doi.org/10.1523/JNEUROSCI.1378-17.2017Test

مصطلحات موضوعية: 0301 basic medicine, Central Nervous System, Male, Axonal loss, Mitochondrion, DNA, Mitochondrial/genetics, Nerve Degeneration/genetics, Mice, 0302 clinical medicine, Inflammation/genetics, DNA Breaks, Double-Stranded, Research Articles, General Neuroscience, Experimental autoimmune encephalomyelitis, Mitochondria, Oligodendroglia/pathology, Oligodendroglia, medicine.anatomical_structure, Locomotion/physiology, Central Nervous System/pathology, Female, Demyelination, Locomotion, Mitochondrial DNA, Encephalomyelitis, Autoimmune, Experimental, Encephalomyelitis, Autoimmune, Experimental/genetics, Demyelinating Diseases/genetics, Mice, Transgenic, Biology, Neuroprotection, DNA, Mitochondrial, Multiple sclerosis, 03 medical and health sciences, medicine, Animals, Animal model, Oxidative phosphorylation, Remyelination, Inflammation, medicine.disease, Oligodendrocyte, Axons, Mice, Inbred C57BL, 030104 developmental biology, Axons/pathology, Nerve Degeneration, Neuroscience, 030217 neurology & neurosurgery, Demyelinating Diseases

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e4a5567ec98e9636c91559b0cac7181Test
https://pubmed.ncbi.nlm.nih.gov/28931570Test

المؤلفون: Claudia V. Pereira, Carlos T. Moraes

مصطلحات موضوعية: 0301 basic medicine, Male, Non-Mendelian inheritance, Mitochondrial DNA, Mitochondrial Diseases, Mitochondrial disease, Mitosis, Mitochondrion, Biology, Genome, DNA, Mitochondrial, Article, 03 medical and health sciences, Genome editing, Transcription Activator-Like Effector Nucleases, medicine, Animals, Humans, Germ-Line Mutation, Genetics, Gene Editing, Transcription activator-like effector nuclease, Models, Genetic, Zinc Fingers, DNA Restriction Enzymes, medicine.disease, Heteroplasmy, Mitochondria, 030104 developmental biology, Mutation, Female, Maternal Inheritance, Energy Metabolism

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b515cab68179806363371a3e0bf61137Test
https://europepmc.org/articles/PMC6986768Test/

المؤلفون: J. Stewart, Carlos T. Moraes, J. Kauppila, Claudia V. Pereira, Nils-Göran Larsson, Sandra R. Bacman

المصدر: Neuromuscular Disorders. 27:S3

مصطلحات موضوعية: Genetics, Mitochondrial DNA, Neurology, Pediatrics, Perinatology and Child Health, Neurology (clinical), Biology, Genetics (clinical), Heteroplasmy

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::31cf9ec8079844fd585b0fd0067982f3Test
https://doi.org/10.1016/s0960-8966Test(17)30226-2