دورية أكاديمية
The burden of mild asthma: Clinical burden and healthcare resource utilisation in the NOVELTY study
| العنوان: | The burden of mild asthma: Clinical burden and healthcare resource utilisation in the NOVELTY study |
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| المؤلفون: | Golam S. M., Janson C., Beasley R., FitzGerald J. M., Harrison T., Chipps B., Hughes R., Mullerova H., Olaguibel J. M., Rapsomaniki E., Reddel H. K., Sadatsafavi M., Benhabib G., Mandhane P., Ruiz X. B., McIvor A., Olmo R. D., Pek B., Lisanti R. E., Petrella R., Marino G., Stollery D., Mattarucco W., Chen M., Nogueira J., Chen Y., Parody M., Gu W., Pascale P., Hui K. M. C., Rodriguez P., Li M., Silva D., Li S., Svetliza G., Ma L., Victorio C. F., Qin G., Rolon R. W., Song W., Yanez A., Tan W., Baines S., Tang Y., Bowler S., Wang C., Bremner P., Wang T., Bull S., Wen F., Carroll P., Wu F., Chaalan M., Xiang P., Farah C., Xiao Z., Hammerschlag G., Xiong S., Hancock K., Yang J., Harrington Z., Katsoulotos G., Zhang C., Kim J., Zhang M., Langton D., Zhang P., Lee D., Zhang W., Peters M., Zheng X., Prassad L., Zhu D., Reddel H., Bolivar Grimaldos F., Sajkov D., Arboleda A. C., Santiago F., Bueno C. M., Simpson F. G., Molina de Salazar D., Tai S., Bendstrup E., Thomas P., Hilberg O., Wark P., Kjellerup C., Cancado J. E. D., Weinreich U., Cunha T., Bonniaud P., Lima M., Brun O., Cardoso A. P., Burgel P. -R., Rabahi M., Chouaid C., Anees S., Couturaud F., Bertley J., de Blic J., Bell A., Debieuvre D., Cheema A., Delsart D., Chouinard G., Demaegdt A., Csanadi M., Demoly P., Dhar A., Deschildre A., Dhillon R., Devouassoux G., Egron C., Kanawaty D., Falchero L., Kelly A., Goupil F., Killorn W., Kessler R., Landry D., Le Roux P., Luton R., Mabire P., Mahay G., Ide Y., Martinez S., Inomata M., Melloni B., Inoue H., Moreau L., Inoue K., Raherison C., Inoue S., Riviere E., Kato M., Roux-Claude P., Kawasaki M., Soulier M., Kawayama T., Vignal G., Kita T., Yaici A., Kobayashi K., Aries S. P., Koto H., Bals R., Nishi K., Beck E., Saito J., Deimling A., Shimizu Y., Feimer J., Shirai T., Grimm-Sachs V., Sugihara N., Groth G., Takahashi K. -I., Herth F., Tashimo H., Hoheisel G., Tomii K., Kanniess F., Yamada T., Lienert T., Yanai M., Mronga S., Javier R. C., Reinhardt J., Dominguez Peregrina A., Schlenska C., Corzo M. F., Stolpe C., Montano Gonzalez E., Teber I., Ramirez-Venegas A., Timmermann H., Rendon A., Ulrich T., Boersma W., Velling P., Djamin R. S., Wehgartner-Winkler S., Eijsvogel M., Welling J., Franssen F., Winkelmann E. -J., Goosens M., Barbetta C., Graat-Verboom L., Braido F., Veen J. I., Cardaci V., Janssen R., Clini E. M., Kuppens K., Costantino M. T., van den Berge M., Cuttitta G., van de Ven M., di Gioacchino M., Brunstad O. P., Fois A., Einvik G., Foschino-Barbaro M. P., Hoines K. J., Gammeri E., Khusrawi A., Inchingolo R., Oien T., Lavorini F., Chang Y. -S., Molino A., Cho Y. J., Nucera E., Hwang Y. I., Papi A., Kim W. J., Patella V., Koh Y. -I., Pesci A., Lee B. -J., Ricciardolo F., Lee K. -H., Rogliani P., Lee S. -P., Sarzani R., Lee Y. C., Vancheri C., Lim S. Y., Vincenti R., Min K. H., Endo T., Oh Y. -M., Fujita M., Park C. -S., Hara Y., Park H. -S., Horiguchi T., Park H. -W., Hosoi K., Rhee C. K., Yoon H. J., Morice A., Yoon H. -K., Pandya P., Garcia-Navarro A. A., Patel M., Andujar R., Roy K., Anoro L., Sathyamurthy R., Garcia M. B., Thiagarajan S., Mozo P. C., Turner A., Campos S., Vestbo J., Maldonado F. C., Wedzicha W., Castilla Martinez M., Wilkinson T., Serrano C. C., Wilson P., Comeche Casanova L., Al-Asadi L. A., Corbacho D., Anholm J., Campo Matias F. D., Averill F., Echave-Sustaeta J., Bansal S., Corral G. F., Baptist A., Gamboa Setien P., Campbell C., Garcia Clemente M., Campos M. A., Nunez I. G., Robaina J. G., Crook G., Garcia Salmones M., DeLeon S., Marin Trigo J. M., Eid A., Fernandez M. N., Epstein E., Palomo S. N., Fritz S., Olaguibel Rivera J., Harris H., de Llano L. P., Hewitt M., Pueyo Bastida A., Holguin F., Rano A., Hudes G., Rodriguez Gonzalez-Moro J., Jackson R., Reig A. R., Kaufman A., Velasco Garrido J., Kaufman D., Curiac D., Klapholz A., Krishna H., Lif-Tiberg C., Luts A., Lin R., Rahlen L., Maselli-Caceres D., Rustscheff S., Mehta V., Adams F., Moy J. N., Bradman D., Nwokoro U., Broughton E., Parikh P., Cosgrove J., Parikh S., Flood-Page P., Perrino F., Fuller E., Ruhlmann J., Sassoon C., Hartley D., Settipane R. A., Hattotuwa K., Sousa D., Jones G., Sriram P., Lewis K., Wachs R., McGarvey L. |
| المساهمون: | Golam, S. M., Janson, C., Beasley, R., Fitzgerald, J. M., Harrison, T., Chipps, B., Hughes, R., Mullerova, H., Olaguibel, J. M., Rapsomaniki, E., Reddel, H. K., Sadatsafavi, M., Benhabib, G., Mandhane, P., Ruiz, X. B., Mcivor, A., Olmo, R. D., Pek, B., Lisanti, R. E., Petrella, R., Marino, G., Stollery, D., Mattarucco, W., Chen, M., Nogueira, J., Chen, Y., Parody, M., Gu, W., Pascale, P., Hui, K. M. C., Rodriguez, P., Li, M., Silva, D., Li, S., Svetliza, G., Ma, L., Victorio, C. F., Qin, G., Rolon, R. W., Song, W., Yanez, A., Tan, W., Baines, S., Tang, Y., Bowler, S., Wang, C., Bremner, P., Wang, T., Bull, S., Wen, F., Carroll, P., Wu, F., Chaalan, M., Xiang, P., Farah, C., Xiao, Z., Hammerschlag, G., Xiong, S., Hancock, K., Yang, J., Harrington, Z., Katsoulotos, G., Zhang, C., Kim, J., Zhang, M., Langton, D., Zhang, P., Lee, D., Zhang, W., Peters, M., Zheng, X., Prassad, L., Zhu, D., Reddel, H., Bolivar Grimaldos, F., Sajkov, D., Arboleda, A. C., Santiago, F., Bueno, C. M., Simpson, F. G., Molina de Salazar, D., Tai, S., Bendstrup, E., Thomas, P., Hilberg, O., Wark, P., Kjellerup, C., Cancado, J. E. D., Weinreich, U., Cunha, T., Bonniaud, P., Lima, M., Brun, O., Cardoso, A. P., Burgel, P. -R., Rabahi, M., Chouaid, C., Anees, S., Couturaud, F. |
| سنة النشر: | 2022 |
| المجموعة: | Archivio della ricerca dell'Università di Modena e Reggio Emilia (Unimore: IRIS) |
| مصطلحات موضوعية: | Disease burden, Healthcare resource utilisation, Longitudinal studie, Mild asthma, Patient-reported measure, Adrenal Cortex Hormone, Disease Progression, Human, Patient Acceptance of Health Care, Prospective Studie, Asthma |
| الوصف: | Background: Patients with mild asthma represent a substantial proportion of the population with asthma, yet there are limited data on their true burden of disease. We aimed to describe the clinical and healthcare resource utilisation (HCRU) burden of physician-assessed mild asthma. Methods: Patients with mild asthma were included from the NOVEL observational longiTudinal studY (NOVELTY; NCT02760329), a global, 3-year, real-world prospective study of patients with asthma and/or chronic obstructive pulmonary disease from community practice (specialised and primary care). Diagnosis and severity were based on physician discretion. Clinical burden included physician-reported exacerbations and patient-reported measures. HCRU included inpatient and outpatient visits. Results: Overall, 2004 patients with mild asthma were included; 22.8% experienced ≥1 exacerbation in the previous 12 months, of whom 72.3% experienced ≥1 severe exacerbation. Of 625 exacerbations reported, 48.0% lasted >1 week, 27.7% were preceded by symptomatic worsening lasting >3 days, and 50.1% required oral corticosteroid treatment. Health status was moderately impacted (St George's Respiratory Questionnaire score: 23.5 [standard deviation ± 17.9]). At baseline, 29.7% of patients had asthma symptoms that were not well controlled or very poorly controlled (Asthma Control Test score <20), increasing to 55.6% for those with ≥2 exacerbations in the previous year. In terms of HCRU, at least one unscheduled ambulatory visit for exacerbations was required by 9.5% of patients, including 9.2% requiring ≥1 emergency department visit and 1.1% requiring ≥1 hospital admission. Conclusions: In this global sample representing community practice, a significant proportion of patients with physician-assessed mild asthma had considerable clinical burden and HCRU. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/35952579; info:eu-repo/semantics/altIdentifier/wos/WOS:000843532200001; volume:200; firstpage:106863; lastpage:N/A; journal:RESPIRATORY MEDICINE; http://hdl.handle.net/11380/1288263Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85135716693 |
| DOI: | 10.1016/j.rmed.2022.106863 |
| الإتاحة: | https://doi.org/10.1016/j.rmed.2022.106863Test http://hdl.handle.net/11380/1288263Test |
| حقوق: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.E5E4036F |
| قاعدة البيانات: | BASE |
| DOI: | 10.1016/j.rmed.2022.106863 |
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