المؤلفون: Lori L. Bonnycastle, Henna Cederberg, Alena Stančáková, Jussi Paananen, Pasi Soininen, Mika Ala-Korpela, Francis S. Collins, Niyas K. Saleem, Jussi Pihlajamäki, Jagadish Vangipurapu, Antti J. Kangas, Michael Boehnke, Yuvaraj Mahendran, Päivi Pajukanta, Karen L. Mohlke, Mete Civelek, Johanna Kuusisto, Mario A. Morken, Markku Laakso, Aldons J. Lusis

المصدر: Diabetes

مصطلحات موضوعية: Blood Glucose, Male, medicine.medical_specialty, Endocrinology, Diabetes and Metabolism, Population, Adipose tissue, 030209 endocrinology & metabolism, Ketone Bodies, Type 2 diabetes, Biology, Polymorphism, Single Nucleotide, White People, Acetoacetates, 03 medical and health sciences, 0302 clinical medicine, Insulin resistance, Predictive Value of Tests, Risk Factors, Diabetes mellitus, Internal medicine, Internal Medicine, medicine, Humans, education, Finland, Original Research, 030304 developmental biology, Metabolic Syndrome, 0303 health sciences, education.field_of_study, Glucose tolerance test, 3-Hydroxybutyric Acid, medicine.diagnostic_test, Genetics/Genomes/Proteomics/Metabolomics, Fasting, Glucose Tolerance Test, Middle Aged, medicine.disease, 3. Good health, Endocrinology, Diabetes Mellitus, Type 2, Area Under Curve, Hyperglycemia, Ketone bodies, Metabolic syndrome, Biomarkers, Genome-Wide Association Study

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54e1c59be6633575f8252cac23cf204fTest
https://doi.org/10.2337/db12-1363Test

المؤلفون: Amanda J. Bennett, Lori L. Bonnycastle, Inês Barroso, Gudmar Thorleifsson, Charlotta Pisinger, Timothy M. Frayling, Laura J. Scott, Christian Herder, Mark Walker, Markku Laakso, Laura Pascoe, Beverley M. Shields, Thomas Sparsø, Ele Ferrannini, John R. B. Perry, Torsten Lauritzen, Felicity Payne, Thomas Illig, Michael N. Weedon, Beatrice Knight, Luigi Ferrucci, Giuseppe Paolisso, Claudia Langenberg, Andrew D. Morris, Torben Hansen, Ewan R. Pearson, Oluf Pedersen, Annelli Sandbæk, Peter Schwarz, Mario A. Morken, Colin N. A. Palmer, Peter Nilsson, Marcello Maggio, Narisu Narisu, Katharine R. Owen, Stefan R. Bornstein, Michael Boehnke, Mike Sampson, Leif Groop, Marjo-Riitta Järvelin, Aimo Ruokonen, Andrew T. Hattersley, Valgerdur Steinthorsdottir, Unnur Thorsteinsdottir, Ele Zeggini Magic, Mark I. McCarthy, Cecilia M. Lindgren, Christopher J. Groves, Elizabeth H. Young, Johanna Kuusisto, Harald Grallert, Valeriya Lyssenko, Anette P. Gjesing, Malin Neptin, Anne U. Jackson, Kari Stefansson, Nicholas J. Wareham, Heather M. Stringham

المساهمون: Perry, Jr, Weedon, Mn, Langenberg, C, Jackson, Au, Lyssenko, V, Sparsø, T, Thorleifsson, G, Grallert, H, Ferrucci, L, Maggio, M, Paolisso, Giuseppe, Walker, M, Palmer, Cn, Payne, F, Young, E, Herder, C, Narisu, N, Morken, Ma, Bonnycastle, Ll, Owen, Kr, Shields, B, Knight, B, Bennett, A, Groves, Cj, Ruokonen, A, Jarvelin, Mr, Pearson, E, Pascoe, L, Ferrannini, E, Bornstein, Sr, Stringham, Hm, Scott, Lj, Kuusisto, J, Nilsson, P, Neptin, M, Gjesing, Ap, Pisinger, C, Lauritzen, T, Sandbaek, A, Sampson, M, Zeggini, Me, Lindgren, Cm, Steinthorsdottir, V, Thorsteinsdottir, U, Hansen, T, Schwarz, P, Illig, T, Laakso, M, Stefansson, K, Morris, Ad, Groop, L, Pedersen, O, Boehnke, M, Barroso, I, Wareham, Nj, Hattersley, At, Mccarthy, Mi, Frayling, Tm

المصدر: Perry, J R B, Weedon, M N, Langenberg, C, Jackson, A U, Lyssenko, V, Sparsø, T, Thorleifsson, G, Grallert, H, Ferrucci, L, Maggio, M, Paolisso, G, Walker, M, Palmer, C N A, Payne, F, Young, E, Herder, C, Narisu, N, Morken, M A, Bonnycastle, L L, Owen, K R, Shields, B, Knight, B, Bennett, A, Groves, C J, Ruokonen, A, Jarvelin, M R, Pearson, E, Pascoe, L, Ferrannini, E, Bornstein, S R, Stringham, H M, Scott, L J, Kuusisto, J, Nilsson, P, Neptin, M, Gjesing, A P, Pisinger, C, Lauritzen, T, Sandbaek, A, Sampson, M, Zeggini, E, Lindgren, C M, Steinthorsdottir, V, Thorsteinsdottir, U, Hansen, T, Schwarz, P, Illig, T, Laakso, M, Stefansson, K, Morris, A D, Groop, L, Pedersen, O, Boehnke, M, Barroso, I, Wareham, N J, Hattersley, A T, McCarthy, M I & Frayling, T M 2010, ' Genetic evidence that raised sex hormone binding globulin (SHBG) levels reduce the risk of type 2 diabetes ', Human Molecular Genetics, vol. 19, no. 3, pp. 535-44 . https://doi.org/10.1093/hmg/ddp522Test
Hum. Mol. Genet. 19, 535-544 (2010)
Human Molecular Genetics
Perry, J R B, Weedon, M N, Langenberg, C, Jackson, A U, Lyssenko, V, Sparsø, T, Thorleifsson, G, Grallert, H, Ferrucci, L, Maggio, M, Paolisso, G, Walker, M, Palmer, C N A, Payne, F, Young, E, Herder, C, Narisu, N, Morken, M A, Bonnycastle, L L, Owen, K R, Shields, B, Knight, B, Bennett, A, Groves, C J, Ruokonen, A, Jarvelin, M R, Pearson, E, Pascoe, L, Ferrannini, E, Bornstein, S R, Stringham, H M, Scott, L J, Kuusisto, J, Nilsson, P, Neptin, M, Gjesing, A P, Pisinger, C, Lauritzen, T, Sandbaek, A, Sampson, M, Zeggini, E, Lindgren, C M, Steinthorsdottir, V, Thorsteinsdottir, U, Hansen, T, Schwarz, P, Illig, T, Laakso, M, Stefansson, K, Morris, A D & MAGIC 2010, ' Genetic evidence that raised sex hormone binding globulin (SHBG) levels reduce the risk of type 2 diabetes ', Human Molecular Genetics, vol. 19, no. 3, pp. 535-44 . https://doi.org/10.1093/hmg/ddp522Test
Human Molecular Genetics; Vol 19

مصطلحات موضوعية: Male, AUGSBURG CASE-COHORT, Genome-wide association study, Type 2 diabetes, 0302 clinical medicine, Sex hormone-binding globulin, Risk Factors, Sex Hormone-Binding Globulin, polycyclic compounds, Gonadal Steroid Hormones, 11 Medical and Health Sciences, Genetics (clinical), reproductive and urinary physiology, Genetics & Heredity, 0303 health sciences, biology, INSULIN SENSITIVITY, Association Studies Articles, General Medicine, Middle Aged, PROSTATE-CANCER, 3. Good health, POSTMENOPAUSAL WOMEN, MENDELIAN RANDOMIZATION, Female, TESTOSTERONE TREATMENT, Life Sciences & Biomedicine, hormones, hormone substitutes, and hormone antagonists, Adult, Biochemistry & Molecular Biology, medicine.medical_specialty, BODY-COMPOSITION, 030209 endocrinology & metabolism, Single-nucleotide polymorphism, STEROID-HORMONES, Polymorphism, Single Nucleotide, 03 medical and health sciences, Diabetes mellitus, Internal medicine, Mendelian randomization, Genetics, medicine, Humans, GENOME-WIDE ASSOCIATION, Molecular Biology, 030304 developmental biology, Aged, Science & Technology, Case-control study, Odds ratio, 06 Biological Sciences, medicine.disease, MAGIC, SERUM CONCENTRATIONS, Endocrinology, Diabetes Mellitus, Type 2, Case-Control Studies, biology.protein

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::600143c243d47c13257cb5941263f66bTest
https://ora.ox.ac.uk/objects/uuid:a806a09e-f734-4a9e-91c3-54be07dd26cdTest

المؤلفون: Sarah L. Ruppert, Anna L. Gloyn, Amy J. Swift, Ilana Blech, Clesson Turner, James C. Mullikin, David Ng, Francis S. Collins, Leslie G. Biesecker, Matthew G. Rees, Mario A. Morken, Jennifer E. Below, Nicola L. Beer, Mark I. McCarthy

مصطلحات موضوعية: Nonsynonymous substitution, Male, Active Transport, Cell Nucleus, Mutation, Missense, Polymorphism, Single Nucleotide, Cohort Studies, Evolution, Molecular, Glucokinase, Missense mutation, Glucose homeostasis, Humans, Frameshift Mutation, Gene, Cellular localization, Triglycerides, Adaptor Proteins, Signal Transducing, Aged, Genetics, Glucokinase regulatory protein, biology, Genetic Variation, General Medicine, Exons, Middle Aged, Recombinant Proteins, Kinetics, Phenotype, Amino Acid Substitution, Codon, Nonsense, biology.protein, Female, Common disease-common variant, Research Article, HeLa Cells

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00dd9fe28756d4ed0f5935834f03659cTest
https://doi.org/10.1172/jci46425Test

المؤلفون: Michael Boehnke, Luigi Ferrucci, Aarti Surti, Jaakko Tuomilehto, Karen L. Mohlke, Candace Guiducci, Lee M. Kaplan, Rory Collins, Leena Peltonen, Qiong Yang, Cristen J. Willer, Francis S. Collins, Angelo Scuteri, Christopher J. O'Donnell, Edward G. Lakatta, Serkalem Demissie, Johanna Kuusisto, John C. Chambers, Amy J. Swift, Leif Groop, Markku Laakso, Gina M. Peloso, Sekar Kathiresan, Jouko Sundvall, G. Mark Lathrop, Gonçalo R. Abecasis, Benjamin F. Voight, Jose M. Ordovas, Veikko Salomaa, Eric E. Schadt, Robert Clarke, David Altshuler, David Schlessinger, Diana Zelenika, Pilar Galan, Serge Hercberg, Derrick A Bennett, Kari Kubalanza, Laura J. Scott, Kiran Musunuru, Kathryn L. Lunetta, Serena Sanna, Marju Orho-Melander, L. Adrienne Cupples, Toshiko Tanaka, Gabriel Crawford, Pierre Meneton, Josée Dupuis, Anne U. Jackson, Sarah Parish, Paul I.W. de Bakker, Yun Li, Olle Melander, Mario A. Morken, Manuela Uda, Heather M. Stringham, Lori L. Bonnycastle, Noël P. Burtt, Paul Scheet, Richard N. Bergman, Jaspal S. Kooner

مصطلحات موضوعية: Adult, Male, Multifactorial Inheritance, medicine.medical_specialty, Quantitative Trait Loci, Blood lipids, Genome-wide association study, 030204 cardiovascular system & hematology, Biology, Polymorphism, Single Nucleotide, Article, 03 medical and health sciences, chemistry.chemical_compound, Delta-5 Fatty Acid Desaturase, 0302 clinical medicine, Meta-Analysis as Topic, ANGPTL4, Internal medicine, Genetics, medicine, Humans, RNA, Messenger, Allele, Alleles, Triglycerides, Dyslipidemias, 030304 developmental biology, 0303 health sciences, Triglyceride, Cholesterol, Cholesterol, HDL, Reproducibility of Results, Cholesterol, LDL, Syndrome, Middle Aged, medicine.disease, 3. Good health, Phenotype, Endocrinology, Gene Expression Regulation, Liver, chemistry, Female, lipids (amino acids, peptides, and proteins), Dyslipidemia, Genome-Wide Association Study, Lipoprotein

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d725a804494fa65d0b3eab2f377b0f76Test
https://ora.ox.ac.uk/objects/uuid:4bf7b381-5e10-41d4-99a6-b6501ceded24Test

المؤلفون: Pasi Soininen, Markku Laakso, Michael Boehnke, Alena Stančáková, Niyas K. Saleem, Aldons J. Lusis, Mario A. Morken, Mika Ala-Korpela, Päivi Pajukanta, Henna Cederberg, Antti J. Kangas, Johanna Kuusisto, Lori L. Bonnycastle, Jussi Pihlajamäki, Jussi Paananen, Francis S. Collins, Mete Civelek

المصدر: Diabetes

مصطلحات موضوعية: Blood Glucose, Male, medicine.medical_specialty, Endocrinology, Diabetes and Metabolism, 030209 endocrinology & metabolism, Type 2 diabetes, Biology, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Insulin resistance, Internal medicine, Internal Medicine, medicine, Aromatic amino acids, Humans, Genetic Predisposition to Disease, Amino Acids, Finland, 030304 developmental biology, Adaptor Proteins, Signal Transducing, Aged, Alanine, chemistry.chemical_classification, 0303 health sciences, Genetics/Genomes/Proteomics/Metabolomics, Middle Aged, medicine.disease, 3. Good health, Amino acid, Glutamine, Endocrinology, chemistry, Adipose Tissue, Diabetes Mellitus, Type 2, Gene Expression Regulation, Hyperglycemia, Metabolic syndrome, Leucine, Insulin Resistance

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::527233e0be12f87b130f3fe112c321caTest
http://europepmc.org/articles/PMC3379649Test

المؤلفون: Mika Ala-Korpela, Antti J. Kangas, Lori L. Bonnycastle, Johanna Kuusisto, Jussi Paananen, Francis S. Collins, Markku Laakso, Michael Boehnke, Mario A. Morken, Alena Stančáková, Anne U. Jackson, Pasi Soininen

المصدر: Diabetes

مصطلحات موضوعية: Fatty Acid Desaturases, Male, Very low-density lipoprotein, medicine.medical_specialty, Magnetic Resonance Spectroscopy, Genotype, Endocrinology, Diabetes and Metabolism, Population, Cholesterol, VLDL, Single-nucleotide polymorphism, Type 2 diabetes, Biology, Lipoproteins, VLDL, Polymorphism, Single Nucleotide, White People, chemistry.chemical_compound, Delta-5 Fatty Acid Desaturase, Internal medicine, Internal Medicine, medicine, Genetics, Humans, Receptor, Notch2, Risk factor, education, Adaptor Proteins, Signal Transducing, education.field_of_study, Cholesterol, Middle Aged, medicine.disease, Lipoproteins, LDL, Endocrinology, chemistry, Diabetes Mellitus, Type 2, Lipoproteins, IDL, Hyperglycemia, lipids (amino acids, peptides, and proteins), Metabolic syndrome, Lipoproteins, HDL, Lipoprotein

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83e6fb48e496803b617a6cca962e7a9dTest
http://europepmc.org/articles/PMC3292337Test