التفاصيل البيبلوغرافية
| العنوان: |
Predictors of survival trajectories among women with epithelial ovarian cancer |
| المؤلفون: |
Peres, Lauren C, Sinha, Sweta, Townsend, Mary K, Fridley, Brooke L, Karlan, Beth Y, Lutgendorf, Susan K, Shinn, Eileen, Sood, Anil K, Tworoger, Shelley S |
| المصدر: |
Gynecologic Oncology, vol 156, iss 2 |
| بيانات النشر: |
eScholarship, University of California |
| سنة النشر: |
2020 |
| المجموعة: |
University of California: eScholarship |
| مصطلحات موضوعية: |
Biomedical and Clinical Sciences, Oncology and Carcinogenesis, Rare Diseases, Clinical Research, Ovarian Cancer, Prevention, Cancer, 2.4 Surveillance and distribution, Aetiology, Good Health and Well Being, Aged, Black People, Carcinoma, Ovarian Epithelial, Female, Humans, Middle Aged, Native Hawaiian or Other Pacific Islander, Neoplasm Staging, Ovarian Neoplasms, Prognosis, SEER Program, United States, White People, Long-term survivors, Mortality, Histotype, Paediatrics and Reproductive Medicine, Oncology & Carcinogenesis, Clinical sciences |
| جغرافية الموضوع: |
459 - 466 |
| الوصف: |
ObjectiveAlthough ovarian cancer is a deadly disease, approximately a third of women survive ≥9years after diagnosis. The factors associated with achieving long-term survival are not well understood. In this study, data from the Surveillance, Epidemiology, and End Results (SEER) program were used to determine predictors of survival trajectories among women with epithelial ovarian cancer and across histotype (high-grade serous carcinoma (HGSC) and non-HGSC).MethodsData on 35,868 women diagnosed with epithelial ovarian cancer in 2004-2016 were extracted from SEER. Extended Cox proportional hazards regression was used to estimate overall and histotype-specific associations between patient and tumor characteristics and all-cause mortality within each survival time (t) interval (t<3, 3≤t<6, 6≤t<9, and 9≤t<13years).ResultsAge at diagnosis, marital status, race/ethnicity, stage, and surgery were more strongly associated with mortality in the short-term survival period, and these associations waned with increasing survival time. Exceptions to this pattern were age >70years at diagnosis, where a high risk of mortality was observed in both the t<3 and t≥9year time periods, and non-Hispanic Asian/Pacific Islanders, where a more pronounced inverse association with mortality was observed in t≥9years after diagnosis. Similar associations were observed for HGSC, although the waning effect was not apparent for most characteristics. Mortality associations for non-HGSC were more pronounced for stage and race/ethnicity, primarily for non-Hispanic Asian/Pacific Islanders.ConclusionsMost patient and tumor characteristics were more strongly associated with mortality in the years following diagnosis, but have declining impact with increasing survival time. Given this waning effect, it is critical to identify factors impacting risk of mortality as ovarian cancer patients advance through the survival trajectory. |
| نوع الوثيقة: |
article in journal/newspaper |
| وصف الملف: |
application/pdf |
| اللغة: |
unknown |
| العلاقة: |
qt3rk0m6v6; https://escholarship.org/uc/item/3rk0m6v6Test |
| الإتاحة: |
https://escholarship.org/uc/item/3rk0m6v6Test |
| حقوق: |
public |
| رقم الانضمام: |
edsbas.CE244975 |
| قاعدة البيانات: |
BASE |
