Effects of oral/enteral nutrition alone versus plus pantoprazole on gastrointestinal bleeding in critically ill patients with low risk factor: A multicenter, randomized controlled trial
| العنوان: | Effects of oral/enteral nutrition alone versus plus pantoprazole on gastrointestinal bleeding in critically ill patients with low risk factor: A multicenter, randomized controlled trial |
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| المؤلفون: | Emre Karakoc, Avşar Zerman, Kursat Gundogan, Muhammet Güven, Murat Sungur, Aliye Esmaoğlu, Turgut Teke, Şahin Temel |
| المصدر: | Volume: 50, Issue: 4 776-783 Turkish Journal of Medical Sciences |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Male, Risk, medicine.medical_specialty, Gastrointestinal bleeding, Critical Care, Critical Illness, pantoprazole, gastrointestinal bleeding, Critical illness,enteral nutrition,pantoprazole,gastrointestinal bleeding,stress ulcer, 030204 cardiovascular system & hematology, Enteral administration, Article, law.invention, 03 medical and health sciences, Enteral Nutrition, 0302 clinical medicine, Randomized controlled trial, law, Internal medicine, medicine, Humans, Prospective Studies, Risk factor, Aged, Enteral Tube Feeding, Pantoprazole, 0303 health sciences, 030306 microbiology, business.industry, General Medicine, Middle Aged, Anti-Ulcer Agents, medicine.disease, Intensive care unit, stress ulcer, Treatment Outcome, Parenteral nutrition, Female, Gastrointestinal Hemorrhage, business, medicine.drug |
| الوصف: | Background/aim: Critically ill patients are at risk of developing gastrointestinal GI bleeding due to stress causing mucosal damage. Aim of the study was to determine the effect of oral/enteral nutrition with or without concomitant pantoprazole on upper GI bleeding in low risk critically ill patients. Materials and methods: This was a prospective, randomized, open-label, multicenter study conducted with intensive care unit ICU patients receiving oral/enteral nutritional support. Patients were randomly assigned into two groups including intervention group received oral/EN plus pantoprazole and control group received only oral/EN . Results: A total of 300 patients intervention group: 152, control group: 148 participated in the study. Overall, 226 75% patients were fed by orally and 74 25% patients fed by enteral tube feeding. Median duration of nutritional support 4 range: 2-33 days. Overt upper GI bleeding was noted only in one patient 0.65% who was in the intervention group. The overall length of ICU stay of 4 2-105 days, while ICU stay was significantly longer in the intervention group than in the control group P = 0.006 . Conclusions: Our findings seems to indicate that in patients who are at low risk for GI bleeding and under oral/enteral nutritional support, the use of PPIs may not reduce the risk of bleeding, however these results are imprecise because of low event GI bleeding rate and limited power. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 1300-0144 1303-6165 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11269a987ca9b747bfef17b87ef39cbcTest https://avesis.erciyes.edu.tr/publication/details/a86d4246-2cfa-4a81-9439-2b9af85bc62d/oaiTest |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....11269a987ca9b747bfef17b87ef39cbc |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 13000144 13036165 |
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