المؤلفون: Elisa Giovannetti, Laura L. Meijer, Tessa Y S Le Large, Giulia Mantini, Hanneke W. M. van Laarhoven, Nicole C.T. van Grieken, Bart Kok, Connie R. Jimenez, Jaco C. Knol, Geert Kazemier, Thang V. Pham, Niccola Funel, Sander R. Piersma, Maarten F. Bijlsma

المساهمون: Graduate School, CCA - Cancer biology and immunology, AGEM - Amsterdam Gastroenterology Endocrinology Metabolism, Oncology, Center of Experimental and Molecular Medicine, Radiotherapy, Surgery, Medical oncology laboratory, Pathology, Amsterdam Gastroenterology Endocrinology Metabolism

المصدر: JCI Insight
JCI insight, 5(15):e138290. The American Society for Clinical Investigation
JCI Insight, 5(15):e138290
Le Large, T Y S, Mantini, G, Meijer, L L, Pham, T V, Funel, N, van Grieken, N C T, Kok, B, Knol, J, van Laarhoven, H W M, Piersma, S R, Jimenez, C R, Kazemier, G, Giovannetti, E & Bijlsma, M F 2020, ' Microdissected pancreatic cancer proteomes reveal tumor heterogeneity and therapeutic targets ', JCI Insight, vol. 5, no. 15, e138290 . https://doi.org/10.1172/jci.insight.138290Test

مصطلحات موضوعية: 0301 basic medicine, Proteomics, Male, Stromal cell, Proteome, Molecular biology, Biology, Extracellular matrix, 03 medical and health sciences, Mice, 0302 clinical medicine, Stroma, Pancreatic cancer, medicine, Biomarkers, Tumor, Tumor Cells, Cultured, Animals, Humans, Cancer, Aged, Aged, 80 and over, General Medicine, Cell Biology, Middle Aged, medicine.disease, Prognosis, Xenograft Model Antitumor Assays, Extracellular Matrix, Gene Expression Regulation, Neoplastic, Pancreatic Neoplasms, Survival Rate, 030104 developmental biology, Oncology, 030220 oncology & carcinogenesis, Cancer cell, Cancer research, Female, Stromal Cells, Carcinoma, Pancreatic Ductal, Research Article

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6bd1e4d181261da5e96c3a6fad92ba2Test
https://pubmed.ncbi.nlm.nih.gov/32634123Test

المؤلفون: Michal Stark, Elisa Giovannetti, Gerrit Jansen, Larry H. Matherly, Maria Gemelli, Godefridus J. Peters, Erik Thunnissen, Ittai B. Muller, Zhanjun Hou, P. A. Zucali, E. A. Struys, Niccola Funel, M. Perrino, Yehuda G. Assaraf

المساهمون: Medical oncology laboratory, CCA - Cancer biology and immunology, Pathology, Clinical chemistry, AGEM - Inborn errors of metabolism, AGEM - Endocrinology, metabolism and nutrition, Rheumatology, AGEM - Digestive immunity

المصدر: Annals of Oncology, 28(11), 2725-2732. Oxford University Press
Giovannetti, E, Zucali, P A, Assaraf, Y G, Funel, N, Gemelli, M, Stark, M, Thunnissen, E, Hou, Z, Muller, I B, Struys, E A, Perrino, M, Jansen, G, Matherly, L H & Peters, G J 2017, ' Role of proton-coupled folate transporter in pemetrexed resistance of mesothelioma : Clinical evidence and new pharmacological tools ', Annals of Oncology, vol. 28, no. 11, pp. 2725-2732 . https://doi.org/10.1093/annonc/mdx499Test

مصطلحات موضوعية: Male, Mesothelioma, 0301 basic medicine, Oncology, Thymidylate synthase, Immunoenzyme Techniques, Reduced Folate Carrier Protein, chemistry.chemical_compound, 0302 clinical medicine, Tumor Cells, Cultured, Aged, 80 and over, biology, Hematology, Methylation, Middle Aged, Prognosis, Survival Rate, Pemetrexed, 030220 oncology & carcinogenesis, Antifolate, Immunohistochemistry, Female, Proton-Coupled Folate Transporter, medicine.drug, Adult, medicine.medical_specialty, Pleural Neoplasms, 03 medical and health sciences, Internal medicine, Biomarkers, Tumor, medicine, Humans, Gene silencing, Survival rate, Aged, Cell Proliferation, business.industry, Original Articles, Thymidylate Synthase, medicine.disease, 030104 developmental biology, chemistry, Drug Resistance, Neoplasm, biology.protein, Folic Acid Antagonists, business, Follow-Up Studies

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ccf6187f967e64fb83a9f2dcd466830Test
https://doi.org/10.1093/annonc/mdx499Test

المؤلفون: Godefridus J. Peters, Isabella Vittimberga, Editta Baldini, Myriam Chartoire, Luca Boni, Marcello Tiseo, Matteo Brighenti, Fausto Barbieri, Andrea Camerini, Elisa Giovannetti, Francesca Mazzoni, Carmelo Tibaldi, Annalisa Gilli, Richard J. Honeywell

المساهمون: CCA - Imaging and biomarkers, Medical oncology laboratory, AGEM - Re-generation and cancer of the digestive system

المصدر: British journal of cancer, 119(11), 1326-1331. Nature Publishing Group
British Journal of Cancer, 119(11), 1326-1331. Nature Publishing Group
Tibaldi, C, Camerini, A, Tiseo, M, Mazzoni, F, Barbieri, F, Vittimberga, I, Brighenti, M, Boni, L, Baldini, E, Gilli, A, Honeywell, R, Chartoire, M, Peters, G J, Giovannetti, E & Italian Oncological Group of Clinical Research (GOIRC) 2018, ' Cytidine deaminase enzymatic activity is a prognostic biomarker in gemcitabine/platinum-treated advanced non-small-cell lung cancer : a prospective validation study ', British Journal of Cancer, vol. 119, no. 11, pp. 1326-1331 . https://doi.org/10.1038/s41416-018-0307-3Test
British Journal of Cancer

مصطلحات موضوعية: 0301 basic medicine, Oncology, Male, Cancer Research, medicine.medical_specialty, Lung Neoplasms, Predictive markers, Deoxycytidine, Article, Disease-Free Survival, 03 medical and health sciences, 0302 clinical medicine, Medical research, Internal medicine, Carcinoma, Non-Small-Cell Lung, Cytidine Deaminase, Antineoplastic Combined Chemotherapy Protocols, medicine, Carcinoma, Biomarkers, Tumor, Humans, Prospective Studies, Prospective cohort study, Lung cancer, Survival rate, Aged, Retrospective Studies, Aged, 80 and over, business.industry, Retrospective cohort study, Cytidine deaminase, Middle Aged, medicine.disease, Prognosis, Gemcitabine, 030104 developmental biology, 030220 oncology & carcinogenesis, Biomarker (medicine), Female, Cisplatin, business, Non-small-cell lung cancer, medicine.drug

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70a41cf0b0a4002de132af4198423642Test
https://pure.amc.nl/en/publications/cytidine-deaminase-enzymatic-activity-is-a-prognostic-biomarker-in-gemcitabineplatinumtreated-advanced-nonsmallcell-lung-cancer-a-prospective-validation-studyTest(297ba0b2-d07b-4b73-bc30-89fce3b095d5).html

المؤلفون: Carlotta Granchi, Elisa Giovannetti, Amir Avan, Babette Aicher, Daniela Massihnia, Mina Maftouh, Leticia G. Leon, Rajiv S. Raktoe, Anne van Krieken, Niccola Funel, Filippo Minutolo, Antonio Russo, Ugo Boggi, Godefridus J. Peters

المساهمون: Massihnia, D., Avan, A., Funel, N., Maftouh, M., Van Krieken, A., Granchi, C., Raktoe, R., Boggi, U., Aicher, B., Minutolo, F., Russo, A., Leon, L., Peters, G., Giovannetti, E., CCA - Cancer biology and immunology, AGEM - Digestive immunity, Medical oncology laboratory, AGEM - Re-generation and cancer of the digestive system

المصدر: Massihnia, D, Avan, A, Funel, N, Maftouh, M, Van Krieken, A, Granchi, C, Raktoe, R, Boggi, U, Aicher, B, Minutolo, F, Russo, A, Leon, L G, Peters, G J & Giovannetti, E 2017, ' Phospho-Akt overexpression is prognostic and can be used to tailor the synergistic interaction of Akt inhibitors with gemcitabine in pancreatic cancer ', Journal of Hematology and Oncology, vol. 10, no. 1, 9 . https://doi.org/10.1186/s13045-016-0371-1Test
Journal of Hematology & Oncology
Journal of Hematology and Oncology, 10(1):9. BioMed Central
Journal of Hematology & Oncology, Vol 10, Iss 1, Pp 1-17 (2017)

مصطلحات موضوعية: 0301 basic medicine, Oncology, Male, Cancer Research, Biopsy, AKT1, Apoptosis, Akt, Gemcitabine, Pancreatic ductal adenocarcinoma, Synergism, Hematology, Molecular Biology, Deoxycytidine, 0302 clinical medicine, Cell Movement, Tumor Cells, Cultured, Glucose Transporter Type 1, medicine.diagnostic_test, Chemistry, Cell Cycle, Pancreatic Neoplasm, Drug Synergism, lcsh:Diseases of the blood and blood-forming organs, Cell cycle, Middle Aged, lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens, Prognosis, Aged, Carcinoma, Pancreatic Ductal, Female, Humans, Pancreatic Neoplasms, Phosphoproteins, Proto-Oncogene Proteins c-akt, RNA, Messenger, Spheroids, Cellular, 030220 oncology & carcinogenesis, Phosphoprotein, medicine.drug, Human, medicine.medical_specialty, Prognosi, lcsh:RC254-282, Flow cytometry, 03 medical and health sciences, Internal medicine, Pancreatic cancer, medicine, Protein kinase B, PI3K/AKT/mTOR pathway, lcsh:RC633-647.5, Research, Apoptosi, medicine.disease, 030104 developmental biology, Cancer cell, Cancer research

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0527d043c396c119ac955e1ab571ea8Test
https://research.vumc.nl/en/publications/e3915272-5f2e-4b5f-a149-4af093da963cTest

المؤلفون: Yisong Wang, Elisa Giovannetti, Niccola Funel, Jih-Hsiang Lee, Paul S. Meltzer, Jin-Hyeok Hwang, Qiuyan Wang, Seth M. Steinberg, Yonghong Wang, Johannes Voortman, Giuseppe Giaccone, Iacopo Petrini

المساهمون: Medical oncology laboratory, Medical oncology, CCA - Disease profiling

المصدر: Lee, J, Giovannetti, E, Hwang, J H, Petrini, I, Wang, Q Y, Voortman, J, Wang, Y H, Steinberg, S M, Funel, N, Meltzer, P S, Wang, Y S & Giaccone, G 2012, ' Loss of 18q22.3 Involving the Carboxypeptidase of Glutamate-like Gene Is Associated with Poor Prognosis in Resected Pancreatic Cancer ', Clinical Cancer Research, vol. 18, no. 2, pp. 524-533 . https://doi.org/10.1158/1078-0432.CCR-11-1903Test
Clinical Cancer Research, 18(2), 524-533. American Association for Cancer Research Inc.

مصطلحات موضوعية: Male, Dipeptidases, Cancer Research, Pathology, Aged, Aged, 80 and over, Carcinoma, Pancreatic Ductal, Cell Line, Tumor, Chromosomes, Human, Pair 18, Cohort Studies, Comparative Genomic Hybridization, DNA Copy Number Variations, DNA Mutational Analysis, Disease-Free Survival, Female, Genes, Tumor Suppressor, Humans, Kaplan-Meier Estimate, Middle Aged, Pancreatic Neoplasms, Prognosis, Proportional Hazards Models, Proto-Oncogene Proteins, Tumor Suppressor Protein p53, ras Proteins, Chromosome Deletion, Oncology, medicine.disease_cause, 80 and over, Copy-number variation, Tumor, Cell cycle, Pancreatic Ductal, KRAS, Tumor Suppressor, Human, medicine.medical_specialty, Biology, Chromosomes, Article, Cell Line, Proto-Oncogene Proteins p21(ras), Pancreatic cancer, medicine, Gene, Pair 18, Cell growth, Carcinoma, Cancer, medicine.disease, Genes, Cancer research, Comparative genomic hybridization

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b502364e7b1272bcea01d050c9212929Test
https://doi.org/10.1158/1078-0432.ccr-11-1903Test

المؤلفون: Ines J. Beumer, Elisa Giovannetti, Kees Smid, Robert Mauritz, Cees J. van Groeningen, Herbert M. Pinedo, Godefridus J. Peters

المساهمون: Medical oncology, Internal medicine, Medical oncology laboratory, CCA - Innovative therapy

المصدر: Mauritz, R, Giovannetti, E, Beumer, I J, Smid, K, van Groeningen, C J, Pinedo, H M & Peters, G J 2009, ' Polymorphisms in the Enhancer Region of the Thymidylate Synthase Gene Are Associated with Thymidylate Synthase Levels in Normal Tissues but Not in Malignant Tissues of Patients with Colorectal Cancer ', Clinical Colorectal Cancer, vol. 8, no. 3, pp. 146-154 . https://doi.org/10.3816/CCC.2009.n.024Test
Clinical Colorectal Cancer, 8(3), 146-154. Elsevier

مصطلحات موضوعية: Adult, Male, Colorectal cancer, Colon, Thymidylate synthase, Metastasis, Genotype, medicine, Humans, RNA, Messenger, RNA, Neoplasm, Allele, Gene, Aged, Aged, 80 and over, Polymorphism, Genetic, biology, Reverse Transcriptase Polymerase Chain Reaction, Liver Neoplasms, Gastroenterology, Rectum, Thymidylate Synthase, Middle Aged, medicine.disease, Prognosis, Primary tumor, Molecular biology, Phenotype, Enhancer Elements, Genetic, Treatment Outcome, Oncology, biology.protein, Cancer research, Female, Neoplasm Recurrence, Local, Colorectal Neoplasms

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::053976b58f3f2f3db5c3796910b595f6Test
https://doi.org/10.3816/ccc.2009.n.024Test

المؤلفون: Enrico Vasile, Carmelo Tibaldi, G. Leticia Leon, Elisa Giovannetti, Armida D'Incecco

المساهمون: Medical oncology laboratory, CCA - Innovative therapy

المصدر: Journal of Cancer Research and Clinical Oncology, 141(7), 1189-1194. Springer Verlag
Vasile, E, Tibaldi, C, Leon, G L, D'Incecco, A & Giovannetti, E 2015, ' Cytochrome P450 1B1 (CYP1B1) polymorphisms are associated with clinical outcome of docetaxel in non-small cell lung cancer (NSCLC) patients ', Journal of Cancer Research and Clinical Oncology, vol. 141, no. 7, pp. 1189-1194 . https://doi.org/10.1007/s00432-014-1880-3Test

مصطلحات موضوعية: Male, Oncology, Cancer Research, medicine.medical_specialty, Lung Neoplasms, CYP1B1, medicine.medical_treatment, non-small cell lung cancer (NSCLC), Antineoplastic Agents, Single-nucleotide polymorphism, Docetaxel, Polymorphism, Single Nucleotide, Biomarkers, Pharmacological, Polymorphism (computer science), Carcinoma, Non-Small-Cell Lung, Internal medicine, Tumor Cells, Cultured, medicine, Carcinoma, Humans, neoplasms, Genetic Association Studies, Aged, Retrospective Studies, Aged, 80 and over, Chemotherapy, Hematology, business.industry, General Medicine, Middle Aged, Prognosis, medicine.disease, body regions, Treatment Outcome, Chemotherapy, Adjuvant, Cytochrome P-450 CYP1B1, Female, Taxoids, business, medicine.drug

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c5595da0c67b8409b2e8a1b7b1b23d1Test
https://research.vumc.nl/en/publications/96018efa-575a-443a-b58a-d1486c35ebb8Test

المؤلفون: Leticia G. Leon, Niccola Funel, Ugo Boggi, Luca Pollina, Elisa Giovannetti, Amir Avan, Nelide De Lio, Enrico Vasile, Daniela Campani, Valentina Galla, S. Caponi, Hiroko Sudo, Vittorio Perrone, Arjan van der Velde, Godefridus J. Peters, Alfredo Falcone

المساهمون: Medical oncology laboratory, CCA - Innovative therapy

المصدر: PLoS ONE, Vol 7, Iss 11, p e49145 (2012)
Università di Pisa-IRIS
PLoS ONE, 7(11), e49145-e49145. Public Library of Science
PLoS ONE
Giovannetti, E, te Velde, A, Funel, N, Vasile, E, Perrone, V, Leon, L G, De Lio, N, Avan, A, Caponi, S, Pollina, L E, Galla, V, Sudo, H, Falcone, A, Campani, D, Boggi, U & Peters, G J 2012, ' High-Throughput MicroRNA (miRNAs) Arrays Unravel the Prognostic Role of MiR-211 in Pancreatic Cancer ', PLoS ONE, vol. 7, no. 11, pp. e49145-e49145 . https://doi.org/10.1371/journal.pone.0049145Test

مصطلحات موضوعية: Male, Oncology, Cancer Treatment, Bioinformatics, Pathology, Multidisciplinary, Middle Aged, Prognosis, Gene Expression Regulation, Neoplastic, Medicine, Female, Oncology Agents, DNA microarray, Carcinoma, Pancreatic Ductal, Research Article, Adult, medicine.medical_specialty, Pancreatic ductal adenocarcinoma, Science, Pancreatic Cancer, Diagnostic Medicine, Internal medicine, Pancreatic cancer, Gastrointestinal Tumors, microRNA, Biomarkers, Tumor, Genetics, Cancer Genetics, Overall survival, medicine, Carcinoma, Humans, Diagnostic biomarker, Biology, Aged, Retrospective Studies, business.industry, Gene Expression Profiling, Cancers and Neoplasms, Chemotherapy and Drug Treatment, medicine.disease, Pancreatic Neoplasms, Gene expression profiling, MicroRNAs, business, Biomarkers, General Pathology

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c192e74783383401f081e13ca0aa88dTest
http://hdl.handle.net/11568/209018Test

المؤلفون: Elisa Giovannetti, Godefridus J. Peters, Leticia G. Leon, Niccola Funel, Stefano Cereda, Matteo Lucchesi, Michele Reni, Maurizio Cantore, Andrea Mambrini, Michele Ghidini, Paola Pacetti, Enrico Vasile

المساهمون: Giovannetti, E, Pacetti, P, Reni, M, Leon, Lg, Mambrini, A, Vasile, E, Ghidini, M, Funel, N, Lucchesi, M, Cereda, S, Peters, Gj, Cantore, M, Medical oncology laboratory, CCA - Innovative therapy

المصدر: Pharmacogenomics, 12(12), 1641-1652. Future Medicine Ltd.
Giovannetti, E, Pacetti, P, Reni, M, Leon, L G, Mambrini, A, Vasile, E, Ghidini, M, Funel, N, Lucchesi, M, Cereda, S, Peters, G J & Cantore, M 2011, ' Association between DNA-repair polymorphisms and survival in pancreatic cancer patients treated with combination chemotherapy ', Pharmacogenomics, vol. 12, no. 12, pp. 1641-1652 . https://doi.org/10.2217/PGS.11.109Test

مصطلحات موضوعية: Oncology, Male, medicine.medical_specialty, DNA Repair, Docetaxel, Kaplan-Meier Estimate, Pharmacology, Polymorphism, Single Nucleotide, Disease-Free Survival, Capecitabine, Pancreatic cancer, Internal medicine, Antineoplastic Combined Chemotherapy Protocols, Genetics, medicine, Humans, Genetic Association Studies, Aged, Neoplasm Staging, Xeroderma Pigmentosum Group D Protein, Cisplatin, business.industry, Hazard ratio, Combination chemotherapy, Middle Aged, medicine.disease, Prognosis, Gemcitabine, Pancreatic Neoplasms, DNA Repair Enzymes, Drug Resistance, Neoplasm, Molecular Medicine, Female, Taxoids, business, medicine.drug, Epirubicin

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09486a5ac41acd8ee96d4e5b5d9520eeTest

المؤلفون: Valentina Mey, S. Nannizzi, M. Del Tacca, Enrico Vasile, Alfredo Falcone, Cinzia Orlandini, Andrea Antonuzzo, R. Di Marsico, G.J. Peters, A.C. Laan, Romano Danesi, Carmelo Tibaldi, Elisa Giovannetti, S. Ricciardi

المساهمون: Medical oncology laboratory, CCA - Oncogenesis

المصدر: Clinical Cancer Research, 14(6), 1797-1803. American Association for Cancer Research Inc.
Tibaldi, C, Giovannetti, E, Vasile, E, Mey, V, Laan, A C, Nannizzi, S, Di Marsico, R, Antonuzzo, A, Orlandini, C, Ricciardi, S, Del Tacca, M, Peters, G J, Falcone, A & Danesi, R 2008, ' Correlation of CDA, ERCC1, and XPD polymorphisms with response and survival in gemcitabine/cisplatin-treated advanced non-small cell lung cancer patients ', Clinical Cancer Research, vol. 14, no. 6, pp. 1797-1803 . https://doi.org/10.1158/1078-0432.CCR-07-1364Test

مصطلحات موضوعية: Adult, Male, Cancer Research, Lung Neoplasms, medicine.drug_class, Biology, Antimetabolite, Deoxycytidine, Polymorphism, Single Nucleotide, Carcinoma, Non-Small-Cell Lung, Cytidine Deaminase, Antineoplastic Combined Chemotherapy Protocols, medicine, Humans, Lung cancer, Aged, Retrospective Studies, Xeroderma Pigmentosum Group D Protein, Cisplatin, gemcitabine, lung cancer, Predictive marker, Cancer, Cytidine deaminase, Middle Aged, medicine.disease, Endonucleases, Prognosis, Survival Analysis, Gemcitabine, DNA-Binding Proteins, Treatment Outcome, Oncology, Immunology, Cancer research, Disease Progression, Female, ERCC1, medicine.drug

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e634fc8624ca39f2f9d9768ca74abd4cTest
https://research.vumc.nl/en/publications/8cc12f1f-7d3e-490c-be6e-77d108ffcbc2Test