دورية أكاديمية
Comparison of Immediate With Delayed Stenting Using the Minimalist Immediate Mechanical Intervention Approach in Acute ST-Segment-Elevation Myocardial Infarction: The MIMI Study.
| العنوان: | Comparison of Immediate With Delayed Stenting Using the Minimalist Immediate Mechanical Intervention Approach in Acute ST-Segment-Elevation Myocardial Infarction: The MIMI Study. |
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| المؤلفون: | Belle, Loic, Motreff, Pascal, Mangin, Lionel, Range, Grégoire, Marcaggi, Xavier, Antoine, Marie, Ferrier, Nadine, Dubreuil, Olivier, Zemour, Gilles, Souteyrand, Geraud, Caussin, Christophe, Amabile, Nicolas, Isaaz, Karl, Dauphin, Raphaël, Koning, René, Robin, Christophe, Faurie, Benjamin, Bonello, Laurent, Champin, Stanislas, Delhaye, Cédric, Cuilleret, François, Mewton, Nathan, Genty, Céline, Viallon, Magalie, Bosson, Jean Luc, Croisille, Pierre, Mimi Investigators, . |
| المساهمون: | Centre Hospitalier Annecy-Genevois, 74000-Annecy, France, Centre Hospitalier Annecy-Genevois Saint-Julien-en-Genevois, CHU Gabriel Montpied Clermont-Ferrand, CHU Clermont-Ferrand, HOPITAL CHARTRES - DEPT CARDIOL, Ctr Hosp Vichy, CTR HOSP ST LUC ST JOSEPH - DEPT CARDIOL, Centre Hospitalier de Cannes (Centre Hospitalier de Cannes), Centre Hospitalier de Cannes, Institut Mutualiste de Montsouris (IMM), Centre Hospitalier Universitaire de Saint-Etienne CHU Saint-Etienne (CHU ST-E), Service de Cardiologie de l'hopital de la Croix Rousse, Hospices Civils de Lyon (HCL), Clinique St Hilaire ( Service de Cardiologie, Rouen), CLINIQUE CONVERT - CEPT CARDIOL, CRT HOSP MUTUALISTE - CARDIO INST, Vascular research center of Marseille (VRCM), Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre Hospitalier de Valence (CH DE VALENCE), Centre hospitalier de Valence, Centre Hospitalier Régional Universitaire CHU Lille (CHRU Lille), Centre hospitalier Les Chanaux Mâcon, Services de Pneumologie, Exploration Fonctionnelle Respiratoire et Cardiologie (Hôpital Louis Pradel), Centre Hospitalier Universitaire CHU Grenoble (CHUGA), RMN et optique : De la mesure au biomarqueur, Centre de Recherche en Acquisition et Traitement de l'Image pour la Santé (CREATIS), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS) |
| المصدر: | ISSN: 1941-7640 ; EISSN: 1941-7632. |
| بيانات النشر: | HAL CCSD American Heart Association |
| سنة النشر: | 2016 |
| المجموعة: | Université Jean Monnet – Saint-Etienne: HAL |
| مصطلحات موضوعية: | myocardial infarction, infarction, ST-segment–elevation myocardial infarction, MICROVASCULAR OBSTRUCTION, CARDIAC MAGNETIC-RESONANCE, THROMBUS ASPIRATION, RANDOMIZED-TRIAL, NO-REFLOW, IMPLANTATION, MANAGEMENT, THROMBECTOMY, METAANALYSIS, PERCUTANEOUS CORONARY INTERVENTION, stent, [SDV]Life Sciences [q-bio] |
| الوصف: | International audience ; Delayed stent implantation after restoration of normal epicardial flow by a minimalist immediate mechanical intervention aims to decrease the rate of distal embolization and impaired myocardial reperfusion after percutaneous coronary intervention. We sought to confirm whether a delayed stenting (DS) approach (24-48 hours) improves myocardial reperfusion, versus immediate stenting, in patients with acute ST-segment-elevation myocardial infarction undergoing primary percutaneous coronary intervention. ; In the prospective, randomized, open-label minimalist immediate mechanical intervention (MIMI) trial, patients (n=140) with ST-segment-elevation myocardial infarction ≤12 hours were randomized to immediate stenting (n=73) or DS (n=67) after Thrombolysis In Myocardial Infarction 3 flow restoration by thrombus aspiration. Patients in the DS group underwent a second coronary arteriography for stent implantation a median of 36 hours (interquartile range 29-46) after randomization. The primary end point was microvascular obstruction (% left ventricular mass) on cardiac magnetic resonance imaging performed 5 days (interquartile range 4-6) after the first procedure. There was a nonsignificant trend toward lower microvascular obstruction in the immediate stenting group compared with DS group (1.88% versus 3.96%; P=0.051), which became significant after adjustment for the area at risk (P=0.049). Median infarct weight, left ventricular ejection fraction, and infarct size did not differ between groups. No difference in 6-month outcomes was apparent for the rate of major cardiovascular and cerebral events. ; The present findings do not support a strategy of DS versus immediate stenting in patients with ST-segment-elevation infarction undergoing primary percutaneous coronary intervention and even suggested a deleterious effect of DS on microvascular obstruction size. ; URL: http://www.clinicaltrials.govTest. Unique identifier: NCT01360242. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/26957418; hal-01457797; https://amu.hal.science/hal-01457797Test; PUBMED: 26957418 |
| الإتاحة: | https://amu.hal.science/hal-01457797Test |
| رقم الانضمام: | edsbas.2EE274C2 |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |