المؤلفون: Estévez-Gallego, Juan, Álvarez-Bernad, Beatriz, Benet, Pera, Wullschleger, Christoph, Raes, Olivier, Menche, Dirk, Martínez, Juan Carlos, Lucena-Agell, Daniel, Prota, Andrea E., Bonato, Francesca, Bargsten, Katja, Cornelus, Jelle, Giménez-Abián, Juan F., Northcote, Peter, Steinmetz, Michel O., Kamimura, Shinji, Altmann, Karl-Heinz, Paterson, Ian, Gago, Federico, Van der Eycken, Johan, Díaz, José Fernando, Oliva, María A.

المساهمون: Ministerio de Ciencia e Innovación (España), Consejo Superior de Investigaciones Científicas (España), European Commission, Fundación Tatiana Pérez de Guzmán el Bueno, Swiss National Science Foundation, Ministerio de Universidades (España), Paul Scherrer Institute (Switzerland), European Synchrotron Radiation Facility, Club Escola Hungaresa de Esgrima de Pontevedra, Estévez-Gallego, Juan, Álvarez-Bernad, Beatriz, Menche, Dirk, Lucena-Agell, Daniel, Prota, Andrea E., Bonato, Francesca, Giménez-Abián, Juan F., Northcote, Peter, Steinmetz, Michel O., Kamimura, Shinji, Altmann, Karl-Heinz, Paterson, Ian, Gago, Federico, Van der Eycken, Johan, Díaz, José Fernando, Oliva, María A.

مصطلحات موضوعية: Microtubule-stabilizing agents, Peloruside, Laulimalide, Tubulin, Microtubules

العلاقة: #PLACEHOLDER_PARENT_METADATA_VALUE#; info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PID2019-104545RB-I00/ES/BASES ESTRUCTURALES DE LA NEUROTOXICIDAD POR ANTITUMORALES DIRIGIDOS CONTRA TUBULINA: HACIA MEJORES MODULADORES DE MICROTUBULOS CONTRA CANCER Y ENFERMEDADES NEURODEGENERATIVAS/; Publisher's version; https://doi.org/10.1016/j.str.2022.11.006Test; Sí; Structure 31 (2023); http://hdl.handle.net/10261/287910Test; http://dx.doi.org/10.13039/501100004219Test; http://dx.doi.org/10.13039/501100001671Test; http://dx.doi.org/10.13039/501100004837Test; http://dx.doi.org/10.13039/501100000780Test; http://dx.doi.org/10.13039/501100003339Test; http://dx.doi.org/10.13039/501100010805Test

الإتاحة: https://doi.org/10.1016/j.str.2022.11.006Test
https://doi.org/10.13039/501100004219Test
https://doi.org/10.13039/501100001671Test
https://doi.org/10.13039/501100004837Test
https://doi.org/10.13039/501100000780Test
https://doi.org/10.13039/501100003339Test
https://doi.org/10.13039/501100010805Test
http://hdl.handle.net/10261/287910Test

المؤلفون: Jost, Marco, Chen, Yuwen, Gilbert, Luke A, Horlbeck, Max A, Krenning, Lenno, Menchon, Grégory, Rai, Ankit, Cho, Min Y, Stern, Jacob J, Prota, Andrea E, Kampmann, Martin, Akhmanova, Anna, Steinmetz, Michel O, Tanenbaum, Marvin E, Weissman, Jonathan S

المصدر: Molecular Cell. 68(1)

مصطلحات موضوعية: Biological Sciences, Biotechnology, Human Genome, Genetics, Orphan Drug, Cancer, Rare Diseases, Aetiology, Development of treatments and therapeutic interventions, 2.1 Biological and endogenous factors, 5.1 Pharmaceuticals, Antineoplastic Agents, CRISPR-Cas Systems, Colchicine, Drug Resistance, Neoplasm, Gene Expression Regulation, Neoplastic, Genetic Testing, Genetic Vectors, Glycine, HeLa Cells, Humans, K562 Cells, Kinesins, Lentivirus, Microtubules, Mutation, Myelodysplastic Syndromes, RNA, Guide, Kinetoplastida, Recombinant Fusion Proteins, Small Molecule Libraries, Sulfones, Tubulin, Tubulin Modulators, Vinblastine, Hela Cells, CRISPRa, CRISPRi, chemical genetics, drug mechanism of action, drug target identification, genome-wide CRISPR screening, microtubules, rigosertib, Medical and Health Sciences, Developmental Biology, Biological sciences, Biomedical and clinical sciences, Health sciences

وصف الملف: application/pdf

الوصول الحر: https://escholarship.org/uc/item/1d37n4k6Test

المؤلفون: Wieczorek, Michal, Tcherkezian, Joseph, Bernier, Cynthia, Prota, Andrea E, Chaaban, Sami, Rolland, Yannève, Godbout, Claude, Hancock, Mark A, Arezzo, Joseph C, Ocal, Ozhan, Rocha, Cecilia, Olieric, Natacha, Hall, Anita, Ding, Hui, Bramoullé, Alexandre, Annis, Matthew G, Zogopoulos, George, Harran, Patrick G, Wilkie, Thomas M, Brekken, Rolf A, Siegel, Peter M, Steinmetz, Michel O, Shore, Gordon C, Brouhard, Gary J, Roulston, Anne

المصدر: Science Translational Medicine. 8(365)

مصطلحات موضوعية: Neurosciences, Cancer, Neurodegenerative, 5.1 Pharmaceuticals, Development of treatments and therapeutic interventions, Animals, Antineoplastic Agents, Cell Line, Tumor, Crystallography, X-Ray, Dimerization, Genomics, Humans, Lactams, Macrocyclic, Mice, Microscopy, Electron, Microtubules, Mitosis, Neoplasm Transplantation, Neurons, Oxazoles, Tubulin, Vinblastine, Vinca Alkaloids, Vinorelbine, Biological Sciences, Medical and Health Sciences

وصف الملف: application/pdf

الوصول الحر: https://escholarship.org/uc/item/9dr6h535Test

المؤلفون: Marzullo, Paola, Boiarska, Zlata, Perez-Pena, Helena, Abel, Anne-Catherine, Álvarez-Bernad, Beatriz, Lucena-Agell, Daniel, Vasile, Francesca, Sironi, Maurizio, Altmann, Karl-Heinz, Prota, Andrea E., Díaz, J. Fernando, Pieraccini, Stefano, Passarella, Daniele

المصدر: Chemistry - A European Journal, 28 (2)

مصطلحات موضوعية: maytansinol, maytansine binding site, tubulin, microtubules, tubulin binders

وصف الملف: application/application/pdf

العلاقة: info:eu-repo/semantics/altIdentifier/wos/000723218300001; http://hdl.handle.net/20.500.11850/518611Test

الإتاحة: https://doi.org/20.500.11850/518611Test
https://doi.org/10.3929/ethz-b-000518611Test
https://doi.org/10.1002/chem.202103520Test
https://hdl.handle.net/20.500.11850/518611Test

المؤلفون: Matthew, S., Chen, Qi-Yin, Ratnayake, R., Fermaintt, Charles S., Lucena-Agell, Daniel, Bonato, Francesca, Prota, Andrea E., Lim, Seok Ting, Wang, Xiaomeng, Díaz, José Fernando, Risinger, April L., Paul, Valerie J., Oliva, María A., Luesch, H.

المساهمون: National Cancer Institute (US), National Institute of General Medical Sciences (US), University of Florida, Ministerio de Ciencia e Innovación (España), Consejo Superior de Investigaciones Científicas (España), European Commission, Matthew, S., Chen, Qi-Yin, Ratnayake, R., Fermaintt, Charles S., Lucena-Agell, Daniel, Bonato, Francesca, Prota, Andrea E., Lim, Seok Ting, Wang, Xiaomeng, Díaz, José Fernando, Risinger, April L., Paul, Valerie J., Oliva, María A., Luesch, H.

مصطلحات موضوعية: Marine natural product, Cyanobacteria, Total synthesis, Microtubules, Tubulin

العلاقة: #PLACEHOLDER_PARENT_METADATA_VALUE#; info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PID2019-10454RB-I00; info:eu-repo/grantAgreement/EC/H2020/860070; Postprint; https://doi.org/10.1073/pnas.2021847118Test; Sí; PNAS 118 (9) e2021847118 ( 2021); http://hdl.handle.net/10261/235164Test; http://dx.doi.org/10.13039/100007698Test; http://dx.doi.org/10.13039/501100003339Test; http://dx.doi.org/10.13039/501100000780Test; http://dx.doi.org/10.13039/501100004837Test; http://dx.doi.org/10.13039/100000057Test

الإتاحة: https://doi.org/10.1073/pnas.2021847118Test
https://doi.org/10.13039/100007698Test
https://doi.org/10.13039/501100003339Test
https://doi.org/10.13039/501100000780Test
https://doi.org/10.13039/501100004837Test
https://doi.org/10.13039/100000057Test
http://hdl.handle.net/10261/235164Test

المؤلفون: Oliva, María A., Prota, Andrea E., Rodríguez-Salarichs, Javier, Wenxin, Gu, Bennani, Y. L., Jiménez-Barbero, Jesús, Bargsten, Katja, Canales, Ángeles, Steinmetz, Michel O., Díaz, José Fernando

المساهمون: Ministerio de Ciencia e Innovación (España), Instituto de Salud Carlos III, Swiss National Science Foundation, European Commission, Club Escola Hungaresa de Esgrima de Pontevedra, Oliva, María A., Prota, Andrea E., Rodríguez-Salarichs, Javier, Jiménez-Barbero, Jesús, Canales, Ángeles, Steinmetz, Michel O., Díaz, José Fernando

مصطلحات موضوعية: Noscapine, Tubulin, Microtubules, Colchicine, Anticancer drugs

العلاقة: #PLACEHOLDER_PARENT_METADATA_VALUE#; info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PID2019-104545RB-I00; info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/CTQ2016-76263-P; info:eu-repo/grantAgreement/EC/H2020/860070; Postprint; https://doi.org/10.1021/acs.jmedchem.0c00855Test; Sí; J Med Chem 63 (15) 8495–8501 (2020); http://hdl.handle.net/10261/216841Test; http://dx.doi.org/10.13039/501100000780Test; http://dx.doi.org/10.13039/501100004837Test; http://dx.doi.org/10.13039/501100004587Test

الإتاحة: https://doi.org/10.1021/acs.jmedchem.0c00855Test
https://doi.org/10.13039/501100000780Test
https://doi.org/10.13039/501100004837Test
https://doi.org/10.13039/501100004587Test
http://hdl.handle.net/10261/216841Test

المؤلفون: Jost, Marco, Chen, Yuwen, Gilbert, Luke A, Horlbeck, Max A, Krenning, Lenno, Menchon, Grégory, Rai, Ankit, Cho, Min Y, Stern, Jacob J, Prota, Andrea E, Kampmann, Martin, Akhmanova, Anna, Steinmetz, Michel O, Tanenbaum, Marvin E, Weissman, Jonathan S

المساهمون: Hubrecht Institute with UMC

مصطلحات موضوعية: Antineoplastic Agents/pharmacology, Cell Proliferation, Cells, Cultured, Crystallography, X-Ray, Drug Contamination, Glycine/analogs & derivatives, Humans, Microtubules/drug effects, Mutation, Neoplasms/drug therapy, Pharmaceutical Preparations/chemistry, Protein Conformation, Sulfones/pharmacology, Tubulin/chemistry, microtubules, CRISPRi, chemical genetics, rigosertib, CRISPRa, drug mechanism of action, drug target identification, Molecular Biology, Cell Biology, Research Support, Non-U.S. Gov't, Journal Article, N.I.H., Extramural

وصف الملف: application/pdf

العلاقة: https://dspace.library.uu.nl/handle/1874/442183Test

الإتاحة: https://dspace.library.uu.nl/handle/1874/442183Test

المؤلفون: Balaguer, Francisco de Asís, Mühlethaler, Tobias, Estévez-Gallego, Juan, Calvo, Enrique, Giménez-Abián, Juan Francisco, Risinger, April L, Sorensen, Erik J, Vanderwal, Christopher D, Altmann, Karl-Heinz, Mooberry, Susan L, Steinmetz, Michel O, Oliva, María Ángela, Prota, Andrea E, Díaz, J Fernando

المساهمون: Ministerio de Economía y Competitividad (España), Ministerio de Ciencia e Innovación (España), Swiss National Science Foundation

مصطلحات موضوعية: Cyclostreptin, Microtubules, Multidrug resistance, Taxanes, Tubulin

العلاقة: Publisher's version; info:eu-repo/grantAgreement/ES/BFU2016-75319-R; info:eu-repo/grantAgreement/ES/RYC-2011-07900; Int J Mol Sci. 2019; 20(6):E1392; http://hdl.handle.net/20.500.12105/7516Test; International journal of molecular sciences

الإتاحة: https://doi.org/20.500.12105/7516Test
https://doi.org/10.3390/ijms20061392Test
https://hdl.handle.net/20.500.12105/7516Test

المؤلفون: De Asís Balaguer, Francisco, Mühlethaler, Tobias, Estévez-Gallego, Juan, Calvo, Enrique, Giménez-Abián, Juan F., Risinger, April L., Sorensen, Erik J., Vanderwal, Christopher D., Altmann, Karl-Heinz, Mooberry, Susan L., Steinmetz, Michel O., Oliva, María Á., Prota, Andrea E., Díaz, J. Fernando

المصدر: International Journal of Molecular Sciences, 20 (6)

مصطلحات موضوعية: cyclostreptin, tubulin, microtubules, multidrug resistance, taxanes

وصف الملف: application/application/pdf

العلاقة: info:eu-repo/semantics/altIdentifier/wos/000465523400032; http://hdl.handle.net/20.500.11850/336644Test

الإتاحة: https://doi.org/20.500.11850/336644Test
https://doi.org/10.3929/ethz-b-000336644Test
https://doi.org/10.3390/ijms20061392Test
https://hdl.handle.net/20.500.11850/336644Test

المؤلفون: Prota, Andrea E., Bargsten, Katja, Redondo-Horcajo, Mariano, Smith III, Amos B., Yang, Chia-Ping H., McDaid, Hayley M., Paterson, Ian, Horwitz, Susan, Díaz, José Fernando, Steinmetz, Michel O.

المساهمون: Ministerio de Economía y Competitividad (España), National Cancer Institute (US), Breast Cancer Research Foundation, Swiss National Science Foundation, Prota, Andrea E., Redondo-Horcajo, Mariano, Horwitz, Susan, Díaz, José Fernando, Steinmetz, Michel O.

مصطلحات موضوعية: Drug discovery, Microtubules, Molecular mechanism of action, Structure elucidation, X-ray crystallography

العلاقة: #PLACEHOLDER_PARENT_METADATA_VALUE#; info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/BFU2016‐75319‐R; Postprint; https://doi.org/10.1002/cbic.201600696Test; Sí; ChemBioChem 18: 905 –909 (2017); http://hdl.handle.net/10261/243916Test; http://dx.doi.org/10.13039/501100003329Test; http://dx.doi.org/10.13039/100001006Test

الإتاحة: https://doi.org/10.1002/cbic.201600696Test
https://doi.org/10.13039/501100003329Test
https://doi.org/10.13039/100001006Test
http://hdl.handle.net/10261/243916Test