دورية أكاديمية
MiRNAs and Muscle Regeneration: Therapeutic Targets in Duchenne Muscular Dystrophy
| العنوان: | MiRNAs and Muscle Regeneration: Therapeutic Targets in Duchenne Muscular Dystrophy |
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| المؤلفون: | Amelia Eva Aránega, Estefanía Lozano-Velasco, Lara Rodriguez-Outeiriño, Felicitas Ramírez de Acuña, Diego Franco, Francisco Hernández-Torres |
| المصدر: | International Journal of Molecular Sciences, Vol 22, Iss 8, p 4236 (2021) |
| بيانات النشر: | MDPI AG, 2021. |
| سنة النشر: | 2021 |
| المجموعة: | LCC:Biology (General) LCC:Chemistry |
| مصطلحات موضوعية: | microRNA, satellite cell, myogenesis, muscle regeneration, muscular dystrophies, Biology (General), QH301-705.5, Chemistry, QD1-999 |
| الوصف: | microRNAs (miRNAs) are small non-coding RNAs required for the post-transcriptional control of gene expression. MicroRNAs play a critical role in modulating muscle regeneration and stem cell behavior. Muscle regeneration is affected in muscular dystrophies, and a critical point for the development of effective strategies for treating muscle disorders is optimizing approaches to target muscle stem cells in order to increase the ability to regenerate lost tissue. Within this framework, miRNAs are emerging as implicated in muscle stem cell response in neuromuscular disorders and new methodologies to regulate the expression of key microRNAs are coming up. In this review, we summarize recent advances highlighting the potential of miRNAs to be used in conjunction with gene replacement therapies, in order to improve muscle regeneration in the context of Duchenne Muscular Dystrophy (DMD). |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1422-0067 1661-6596 |
| العلاقة: | https://www.mdpi.com/1422-0067/22/8/4236Test; https://doaj.org/toc/1661-6596Test; https://doaj.org/toc/1422-0067Test |
| DOI: | 10.3390/ijms22084236 |
| الوصول الحر: | https://doaj.org/article/3881b0251f67411d9afa2f88817bfc11Test |
| رقم الانضمام: | edsdoj.3881b0251f67411d9afa2f88817bfc11 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 14220067 16616596 |
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| DOI: | 10.3390/ijms22084236 |