دورية أكاديمية
Deletion of plasma Phospholipid Transfer Protein (PLTP) increases microglial phagocytosis and reduces cerebral amyloid-β deposition in the J20 mouse model of Alzheimer's disease
| العنوان: | Deletion of plasma Phospholipid Transfer Protein (PLTP) increases microglial phagocytosis and reduces cerebral amyloid-β deposition in the J20 mouse model of Alzheimer's disease |
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| المؤلفون: | Mansuy, Marine, Baille, Stella, Canet, Geoffrey, Borie, Amélie, Cohen-Solal, Catherine, Vignes, Michel, Perrier, Véronique, Chevallier, Nathalie, Le Guern, Naïg, Deckert, Valérie, Lagrost, Laurent, Givalois, Laurent, Desrumaux, Catherine |
| المساهمون: | Mécanismes moléculaires dans les démences neurodégénératives (MMDN), École Pratique des Hautes Études (EPHE), Université Paris Sciences et Lettres (PSL)-Université Paris Sciences et Lettres (PSL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM), Université de Montpellier (UM), Université Paris Sciences et Lettres (PSL), Laboratoire d'Excellence : Lipoprotéines et Santé : prévention et Traitement des maladies Inflammatoires et du Cancer (LabEx LipSTIC), Institut National de la Recherche Agronomique (INRA)-Université Montpellier 2 - Sciences et Techniques (UM2)-Université Paris-Sud - Paris 11 (UP11)-École Pratique des Hautes Études (EPHE), Université Paris Sciences et Lettres (PSL)-Université Paris Sciences et Lettres (PSL)-Institut Gustave Roussy (IGR)-Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy)-Centre Hospitalier Régional Universitaire de Besançon (CHRU Besançon)-Université de Bourgogne (UB)-Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand (CHU Dijon)-Centre Régional de Lutte contre le cancer Georges-François Leclerc Dijon (UNICANCER/CRLCC-CGFL), UNICANCER-UNICANCER-Institut National de la Santé et de la Recherche Médicale (INSERM)-Fédération Francophone de la Cancérologie Digestive, FFCD-Université de Montpellier (UM)-AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement-Etablissement français du sang Bourgogne-Franche-Comté (EFS BFC)-Centre National de la Recherche Scientifique (CNRS)-Université de Franche-Comté (UFC), Université Bourgogne Franche-Comté COMUE (UBFC)-Université Bourgogne Franche-Comté COMUE (UBFC), Institut des Biomolécules Max Mousseron Pôle Chimie Balard (IBMM), Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM)-Institut de Chimie - CNRS Chimie (INC-CNRS)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Lipides - Nutrition - Cancer Dijon - U1231 (LNC), Université de Bourgogne (UB)-Institut National de la Santé et de la Recherche Médicale (INSERM)-AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement, Université Bourgogne Franche-Comté COMUE (UBFC) |
| المصدر: | ISSN: 1949-2553 ; Oncotarget ; https://u-bourgogne.hal.science/hal-01823805Test ; Oncotarget, 2018, 9 (28), pp.19688-19703. ⟨10.18632/oncotarget.24802⟩ ; http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=view&pathTest[]=24802&pubmed-linkout=1. |
| بيانات النشر: | HAL CCSD Impact journals |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | innate immunity, microglia, phagocytosis, phospholipid transfer protein, Alzheimer's disease, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology |
| الوصف: | International audience ; Plasma phospholipid transfer protein (PLTP) binds and transfers a number of amphipathic compounds, including phospholipids, cholesterol, diacylglycerides, tocopherols and lipopolysaccharides. PLTP functions are relevant for many pathophysiological alterations involved in neurodegenerative disorders (especially lipid metabolism, redox status, and immune reactions), and a significant increase in brain PLTP levels was observed in patients with Alzheimer's disease (AD) compared to controls. To date, it has not been reported whether PLTP can modulate the formation of amyloid plaques, i.e. one of the major histopathological hallmarks of AD. We thus assessed the role of PLTP in the AD context by breeding PLTP-deficient mice with an established model of AD, the J20 mice. A phenotypic characterization of the amyloid pathology was conducted in J20 mice expressing or not PLTP. We showed that PLTP deletion is associated with a significant reduction of cerebral Aβ deposits and astrogliosis, which can be explained at least in part by a rise of Aβ clearance through an increase in the microglial phagocytic activity and the expression of the Aβ-degrading enzyme neprilysin. PLTP arises as a negative determinant of plaque clearance and over the lifespan, elevated PLTP activity could lead to a higher Aβ load in the brain. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/29731975; hal-01823805; https://u-bourgogne.hal.science/hal-01823805Test; https://u-bourgogne.hal.science/hal-01823805/documentTest; https://u-bourgogne.hal.science/hal-01823805/file/oncotarget-09-19688.pdfTest; PUBMED: 29731975; PUBMEDCENTRAL: PMC5929418 |
| DOI: | 10.18632/oncotarget.24802 |
| الإتاحة: | https://doi.org/10.18632/oncotarget.24802Test https://u-bourgogne.hal.science/hal-01823805Test https://u-bourgogne.hal.science/hal-01823805/documentTest https://u-bourgogne.hal.science/hal-01823805/file/oncotarget-09-19688.pdfTest |
| حقوق: | http://creativecommons.org/licenses/byTest/ ; info:eu-repo/semantics/OpenAccess |
| رقم الانضمام: | edsbas.66DBFF14 |
| قاعدة البيانات: | BASE |
| DOI: | 10.18632/oncotarget.24802 |
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